A5072556257- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Nosocomial Infections in ICU
- Cystic Fibrosis Research Advances
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- Quinazolinone synthesis and applications
- Patient Satisfaction in Healthcare
- Healthcare Systems and Technology
- Urinary Tract Infections Management
- Tuberculosis Research and Epidemiology
- Patient-Provider Communication in Healthcare
University of Kansas
2022-2025
Abstract Background Imipenem/relebactam (I/R) demonstrates potent in vitro activity against multidrug-resistant (MDR) Pseudomonas aeruginosa. The objective of this study is to evaluate the real-world effectiveness I/R for treatment MDR infections across U.S. Methods MIRAGE a retrospective, multicenter, observational describing P. aeruginosa pneumonia and bloodstream infections. Patients were included if they received >48h initiated within 7 days index culture. Clinical success was...
Abstract Background CACTUS is a retrospective, matched, multicenter study comparing the efficacy of C/T and CZA for treatment bacteremia or pneumonia due to MDR P. aeruginosa. We found that with resulted in higher rates clinical success compared after controlling baseline differences between cohorts. The objective this determine impact patient subgroups on overall findings. Methods patients were matched 1:1 within each site based severity illness, infection type, time initiation. primary...
Abstract Background CACTUS is a retrospective, matched, multicenter study comparing the efficacy of C/T and CZA for treatment bacteremia or pneumonia due to MDR P. aeruginosa. We previously demonstrated that with resulted in higher rates clinical success compared CZA. The objective this analysis compare day 30 Desirability Outcome Ranking (DOOR) between matched patient pairs. Methods patients were 1:1 within each site based on severity illness, infection type, time initiation. DOOR scale...
Guidelines suggest dual antipseudomonal therapy for empiric treatment of pneumonia caused by gram-negative bacteria in intensive care unit (ICU) patients. Additionally, consideration local susceptibility data and patient-specific risk factors resistance is recommended selecting optimal regimens. However, assessing how to best do this are lacking, it unclear whether a data-based or factor-based approach will better drive appropriate treatment. This study aims compare these 2 strategies.
To evaluate rates of and outcomes associated with antibiotic overuse at hospital discharge for patients common infectious diseases states.Single-center, respective cohort study.A large, academic medical center in the Midwest United States.Adult who received antibiotics community-acquired pneumonia (CAP), uncomplicated cystitis, or mild, non-purulent cellulitis. Patients were excluded if they did not receive antibiotic(s) upon discharge, pregnant, severely immunocompromised, had concomitant...
Abstract Background Community-acquired pneumonia (CAP) is a common infectious disease state that provides multiple opportunities for antimicrobial stewardship interventions to optimize therapy management. Methods This retrospective cohort study evaluated the impact of service-level scorecard (Figure 1) with prescribing feedback on rate guideline concordant and order set utilization in non-immunocompromised, adult patients CAP admitted internal medicine family services. Scorecards were shared...
Abstract Background Ceftolozane-tazobactam (CT) and ceftazidime-avibactam (CZA) are front-line agents for treatment of multidrug-resistant (MDR) Pseudomonas aeruginosa; however, real-world comparative-effectiveness data lacking. Methods CACTUS is a retrospective, matched, multicenter study to compare the efficacy CT CZA among patients with bacteremia or pneumonia due MDR P. aeruginosa. were matched 1:1 within each site by presence/absence septic shock/severe sepsis, infection site, time...