Todd C. Lee
A5056802196- COVID-19 Clinical Research Studies
- Antimicrobial Resistance in Staphylococcus
- Long-Term Effects of COVID-19
- Bacterial Identification and Susceptibility Testing
- Pharmaceutical Practices and Patient Outcomes
- SARS-CoV-2 and COVID-19 Research
- Clostridium difficile and Clostridium perfringens research
- Health Systems, Economic Evaluations, Quality of Life
- Infective Endocarditis Diagnosis and Management
- Microscopic Colitis
- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Pneumocystis jirovecii pneumonia detection and treatment
- Medication Adherence and Compliance
- Sepsis Diagnosis and Treatment
- Streptococcal Infections and Treatments
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Nosocomial Infections in ICU
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- COVID-19 and healthcare impacts
- Antifungal resistance and susceptibility
McGill University
2016-2025
McGill University Health Centre
2016-2025
University of Toronto
2009-2024
Sunnybrook Health Science Centre
2022-2024
Institute of Infection and Immunity
2019-2024
North York General Hospital
2024
Monash Medical Centre
2024
University Health Network
2024
London Health Sciences Centre
2024
Monash University
2024
BackgroundCoronavirus disease 2019 (Covid-19) occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For persons who are exposed, the standard of care is observation and quarantine. Whether hydroxychloroquine can prevent symptomatic infection SARS-CoV-2 unknown.MethodsWe conducted a randomized, double-blind, placebo-controlled trial across United States parts Canada testing as postexposure prophylaxis. We enrolled adults had household or occupational someone...
No effective oral therapy exists for early coronavirus disease 2019 (COVID-19).
Clostridium difficile infection (CDI) is associated with significant morbidity, mortality, and a high risk of recurrence. Proton pump inhibitor (PPI) use an initial episode CDI, PPIs are frequently overprescribed. For many, the could likely be discontinued before CDI recurrence.To determine whether PPI was recurrence, to assess what proportion patients who developed were taking for non-evidence-based indication, evaluate physicians unnecessary in context CDI.We conducted retrospective cohort...
The role of remdesivir in the treatment patients hospital with COVID-19 remains ill defined a global context. World Health Organization Solidarity randomized controlled trial (RCT) evaluated across many countries, Canada enrolling using an expanded data collection format Canadian Treatments for (CATCO) trial. We report on findings, additional demographics, characteristics and clinical outcomes, to explore potential differential effects different health care systems.
Scalable deprescribing interventions may reduce polypharmacy and the use of potentially inappropriate medications (PIMs); however, few studies have been large enough to evaluate impact that on adverse drug events (ADEs).To effect an electronic decision support tool ADEs after hospital discharge among older adults with polypharmacy.This was a cluster randomized clinical trial (≥65 years) hospitalized patients expected survival more than 3 months who were admitted 1 11 acute care hospitals in...
Abstract To combat antimicrobial resistance (AMR), advocates have called for passage of the Pioneering Antimicrobial Subscriptions End Upsurging Resistance (PASTEUR) Act in United States, which would appropriate $6 billion new taxpayer-funded subsidies antibiotic development. However, number antibiotics clinical development, and US Food Drug Administration approvals antibiotics, already markedly increased last 15 years. Thus, instead focusing on more economic subsidies, we recommend reducing...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly emerging virus causing the ongoing disease 2019 (COVID-19) pandemic with no known effective prophylaxis. We investigated whether hydroxychloroquine could prevent SARS-CoV-2 in healthcare workers at high risk of exposure. Methods conducted randomized, double-blind, placebo-controlled clinical trial exposure to persons SARS-CoV-2, including those working emergency departments, intensive care units,...
<h3>Background:</h3> Clinical data on patients admitted to hospital with coronavirus disease 2019 (COVID-19) provide clinicians and public health officials information guide practice policy. The aims of this study were describe COVID-19 intensive care, investigate predictors outcome characterize severe acute respiratory infection. <h3>Methods:</h3> This observational cohort used Canadian from 32 selected hospitals included in a global multisite between Jan. 24 July 7, 2020. Adult pediatric...
Abstract Objective To determine if inhaled and intranasal ciclesonide are superior to placebo at decreasing respiratory symptoms in adult outpatients with covid-19. Design Randomised, double blind, controlled trial. Setting Three Canadian provinces (Quebec, Ontario, British Columbia). Participants 203 adults aged 18 years older polymerase chain reaction confirmed covid-19, presenting fever, cough, or dyspnoea. Intervention were randomised receive either (600 μg twice daily) (200 metered dose...
Nephrotoxicity is a known adverse effect of polymyxin antibiotics, including colistin. Although previous meta-analyses have aimed to characterize colistin-associated nephrotoxicity risk relative other included studies were observational in nature with high confounding and heterogeneity. We conducted this systematic review meta-analysis exclusively randomized controlled trials (RCTs) evaluate the incidence associated colistin versus minimally nephrotoxic antibiotics.We searched PubMed,...
Staphylococcus aureus bloodstream (SAB) infection is a common and severe infectious disease, with 90-day mortality of 15%-30%. Despite this, <3000 people have been randomized into clinical trials treatments for SAB infection. The limited evidence base partly results from infections being difficult to complete at scale using traditional trial methods. Here we provide the rationale framework an adaptive platform applied infections. We detail design features Network Adaptive Platform (SNAP)...
Like all fields of medicine, Infectious Diseases is rife with dogma that underpins much clinical practice. In this study, we discuss 2 specific examples historical practice have been overturned recently by numerous prospective studies: traditional durations antimicrobial therapy and the necessity intravenous (IV)-only for infectious syndromes. These dogmas are based on uncontrolled case series from >50 years ago, amplified opinions eminent experts. contrast, more than 120 modern, randomized...
Traditional approaches to practice guidelines frequently result in dissociation between strength of recommendation and quality evidence.To construct a clinical guideline for pyogenic osteomyelitis management, with new standard evidence resolve the gap evidence, through use novel open access approach utilizing social media tools.This consensus statement systematic review study used from WikiGuidelines Group, an collaborative research project, osteomyelitis. In June 2021 February 2022, authors...
Importance Practice guidelines often provide recommendations in which the strength of recommendation is dissociated from quality evidence. Objective To create a clinical guideline for diagnosis and management adult bacterial infective endocarditis (IE) that addresses gap between evidence strength. Evidence Review This consensus statement systematic review applied an approach previously established by WikiGuidelines Group to construct collaborative guidelines. In April 2022 call new existing...
Importance Despite widespread use, summary evidence from prior meta-analyses has contradictory conclusions regarding whether oseltamivir decreases the risk of hospitalization when given to outpatients. Several large investigator-initiated randomized clinical trials have not yet been meta-analyzed. Objective To assess efficacy and safety in preventing among influenza-infected adult adolescent Data Sources PubMed, Ovid MEDLINE, Embase, Europe PubMed Central, Web Science, Cochrane...
Previous trials have demonstrated the effects of fluvoxamine alone and inhaled budesonide for prevention disease progression among outpatients with COVID-19. To determine whether combination would increase treatment in a highly vaccinated population. Randomized, placebo-controlled, adaptive platform trial. (ClinicalTrials.gov: NCT04727424). 12 clinical sites Brazil. Symptomatic adults confirmed SARS-CoV-2 infection known risk factor to severe disease. Patients were randomly assigned either...