Yoav Keynan
A5052913640- Tuberculosis Research and Epidemiology
- Infective Endocarditis Diagnosis and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Influenza Virus Research Studies
- HIV/AIDS Research and Interventions
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Respiratory viral infections research
- HIV Research and Treatment
- Bacterial Identification and Susceptibility Testing
- HIV, Drug Use, Sexual Risk
- Antifungal resistance and susceptibility
- Immune Cell Function and Interaction
- HIV-related health complications and treatments
- Immune Response and Inflammation
- Bartonella species infections research
- Mycobacterium research and diagnosis
- COVID-19 epidemiological studies
- Viral Infections and Vectors
- Diagnosis and treatment of tuberculosis
- Amoebic Infections and Treatments
- Legionella and Acanthamoeba research
- COVID-19 Clinical Research Studies
- Infectious Diseases and Tuberculosis
University of Manitoba
2016-2025
Universidad de Antioquia
2024
Universidad Pontificia Bolivariana
2019-2024
International Centre for Infectious Diseases
2020-2024
University of British Columbia
2015-2024
Health Sciences Centre
2017-2022
Manitoba Health
2021-2022
University of Calgary
2022
Sunnybrook Health Science Centre
2022
University of Alberta
2022
Host factors and complications have been associated with higher mortality in infective endocarditis (IE). We sought to develop validate a model of clinical characteristics predict 6-month IE.Using large multinational prospective registry definite IE (International Collaboration on Endocarditis [ICE]-Prospective Cohort Study [PCS], 2000-2006, n=4049), survival was developed by Cox proportional hazards modeling inverse probability weighting for surgery treatment internally validated the...
Abstract Severe influenza infection has no effective treatment available. One of the key barriers to developing host-directed therapy is a lack reliable prognostic factors needed guide such therapy. Here, we use network analysis approach identify host associated with severe and fatal outcome. In patients moderate-to-severe diseases, uncover complex landscape immunological pathways, main changes occurring in pathways related circulating neutrophils. Patients disease display excessive...
The role of remdesivir in the treatment patients hospital with COVID-19 remains ill defined a global context. World Health Organization Solidarity randomized controlled trial (RCT) evaluated across many countries, Canada enrolling using an expanded data collection format Canadian Treatments for (CATCO) trial. We report on findings, additional demographics, characteristics and clinical outcomes, to explore potential differential effects different health care systems.
ABSTRACT Community-acquired pyogenic liver abscess caused by Klebsiella pneumoniae is an emerging infectious disease. We explored the capsular polysaccharide synthesis ( cps ) regions of three non-K1, non-K2 K. strains, A1142, A7754, and A1517, from Taiwanese patients experiencing abscess. Two A1142 belonged to serotype K57, while third a new serotype, different previously reported 77 serotypes. Deletion complementation experiments suggested that unique K57 gene, homologue wzy , was...
Host response biomarkers can accurately distinguish between influenza and bacterial infection. However, published require the measurement of many genes, thereby making it difficult to implement them in clinical practice. This study aims identify a single-gene biomarker with high diagnostic accuracy equivalent multi-gene biomarkers. In this study, we combined an integrated genomic analysis 1071 individuals vitro experiments using well-established infection models. We identified biomarker,...
Background. The impact of early valve surgery (EVS) on the outcome Staphylococcus aureus (SA) prosthetic infective endocarditis (PVIE) is unresolved. objective this study was to evaluate association between EVS, performed within first 60 days hospitalization, and SA PVIE International Collaboration Endocarditis–Prospective Cohort Study.
Abstract Background The province of Ontario, Canada, has instituted indefinite school closures (SC) as well other social distancing measures to mitigate the impact novel coronavirus disease 2019 (COVID-19) pandemic. We sought evaluate effect SC on reducing attack rate and need for critical care during COVID-19 outbreaks, while considering scenarios with concurrent implementation self-isolation (SI) symptomatic cases. Methods developed an age-structured agent-based simulation model...
Abstract Vaccines against SARS-CoV-2 have shown high efficacy in clinical trials, yet a full immunologic characterization of these vaccines, particularly within the human upper respiratory tract, is less well known. Here, we enumerate and phenotype T cells nasal mucosa blood using flow cytometry before after vaccination with Pfizer-BioNTech COVID-19 vaccine ( n = 21). Tissue-resident memory (Trm) CD8 + expressing CD69 CD103 increase number ~12 days following first second doses, by 0.31 0.43...
Infective endocarditis (IE) has undergone important changes in its epidemiology worldwide.The study aimed to compare IE epidemiological features and outcomes according predefined European regions between two different time periods the twenty-first century.IE cases from 13 countries were included. Two considered: 2000-2006 2008-2012. considered, United Nations geoscheme for Europe: Southern (SE) Northern-Central Europe (NCE). Comparisons performed periods. A total of 4195 episodes included,...
Abstract Background Scarce data are available comparing infective endocarditis (IE) following surgical aortic valve replacement (SAVR) and transcatheter (TAVR). This study aimed to compare the clinical presentation, microbiological profile, management, outcomes of IE after SAVR versus TAVR. Methods Data were collected from “Infectious Endocarditis TAVR International” (enrollment 2005 2020) “International Collaboration on Endocarditis” 2000 2012) registries. Only patients with an affecting...
Keywords: climate change; amoeba; legionella; free living amoebaMots-Clés : changements climatiques, amibe, légionellose, les amibes libres
Community-acquired primary pyogenic liver abscess (PLA) caused by Klebsiella pneumoniae is an emerging infectious entity, with cases reported in the scientific literature over past 15 y mainly from Taiwan and Asia, but also Europe North America. We describe a case of PLA hypermucoviscous, K1 capsular serotype Canadian man highlight unique features this increasingly common cause abscess.
Because chemokine receptor 5 (CCR5) may have a role in pulmonary immune response, we explored whether patients with severe pandemic (H1N1) 2009 were more likely to carry the CCR5Δ32 allele than members of general population. We found large proportion heterozygosity for among white disease.