Javier González
A5041716910- Infective Endocarditis Diagnosis and Management
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Renal cell carcinoma treatment
- Diverse academic and cultural studies
- Nosocomial Infections in ICU
- Shoulder and Clavicle Injuries
- Helminth infection and control
- Hepatitis B Virus Studies
- Antifungal resistance and susceptibility
- Cytomegalovirus and herpesvirus research
- Aging, Health, and Disability
- Educational theories and practices
- Shoulder Injury and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Herpesvirus Infections and Treatments
- Cardiac Valve Diseases and Treatments
- Sepsis Diagnosis and Treatment
- Antibiotic Use and Resistance
- Orthopedic Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Education and Teacher Training
- Cardiac tumors and thrombi
Hospital General Universitario Gregorio Marañón
2023
Universidad de Antioquia
2008-2020
CIEP
2019
Universidad Autónoma de Bucaramanga
2019
U.S. Salinity Laboratory
2014
Departamento de Salud
2014
Hospital Universitario de San Vicente Fundación
2014
Agricultural Research Service
2008
Biogipuzkoa Health Research Institute
2005
University of the Basque Country
2002
Host factors and complications have been associated with higher mortality in infective endocarditis (IE). We sought to develop validate a model of clinical characteristics predict 6-month IE.Using large multinational prospective registry definite IE (International Collaboration on Endocarditis [ICE]-Prospective Cohort Study [PCS], 2000-2006, n=4049), survival was developed by Cox proportional hazards modeling inverse probability weighting for surgery treatment internally validated the...
Ceftaroline, the active form of prodrug ceftaroline fosamil, is a novel cephalosporin with bactericidal activity against important pathogens associated community-acquired pneumonia (CAP), including Streptococcus pneumoniae and common Gram-negative pathogens. FOCUS 1 randomized, double-blinded, Phase III study that was conducted to evaluate efficacy safety fosamil in treating patients CAP. The primary objective determine non-inferiority [lower limit 95% confidence interval (CI) ≥ −10%]...
Infective endocarditis (IE) has undergone important changes in its epidemiology worldwide.The study aimed to compare IE epidemiological features and outcomes according predefined European regions between two different time periods the twenty-first century.IE cases from 13 countries were included. Two considered: 2000-2006 2008-2012. considered, United Nations geoscheme for Europe: Southern (SE) Northern-Central Europe (NCE). Comparisons performed periods. A total of 4195 episodes included,...
Abstract Background Scarce data are available comparing infective endocarditis (IE) following surgical aortic valve replacement (SAVR) and transcatheter (TAVR). This study aimed to compare the clinical presentation, microbiological profile, management, outcomes of IE after SAVR versus TAVR. Methods Data were collected from “Infectious Endocarditis TAVR International” (enrollment 2005 2020) “International Collaboration on Endocarditis” 2000 2012) registries. Only patients with an affecting...
Although high-performance liquid chromatography with ultraviolet detection (HPLC-PAD) is widely available, it has not been used for artemisinin (1) analysis because of the lack UV absorption reported this lactone. Increased Artemisia annua cultivation production 1 requires an affordable and reliable method to analyse its precursors dihydroartemisinic acid (2) artemisinic (3) simultaneously from underivatized plant extracts.To validate HPLC-PAD quantification A. artemisinin-based drugs.Dried...
Abstract Background: Pancreatic cancer is the fourth leading cause of all cancer-related deaths. Dendritic cells are primary antigen presenting that have capacity to activate both innate and adaptive immune systems. Although peripheral blood derived mature dendritic cell (DC)-based vaccines shown potential multiple anti-tumor responses in-vitro in animal studies, they yielded disappointing results clinical trials. Here we report on a novel allogeneic vaccine (DCCV) platform from CD34+...
To assess the true association between appropriate prescription of antibiotics and prognosis in patients with sepsis, a key issue health care quality improvement strategies.Prospective cohort study three university hospitals to determine whether empirical was adequate or inadequate, compare hospital death rates length stay according different classifications prescription. Logistic regression models for risk estimation were fitted.A total 705 severe sepsis included. No differences found...
Abstract Molecular tests for viral diagnostics are essential to confront the COVID-19 pandemic, but their production and distribution cannot satisfy current high demand. Early identification of infected people contacts is key being able isolate them prevent dissemination pathogen; unfortunately, most countries unable do this due lack diagnostic tools. Dogs can identify, with a rate precision, unique odors volatile organic compounds generated during an infection; as result, dogs diagnose...
Negligible in vivo growth of enterococci and high-level dispersion data have led to inaccurate estimations antibiotic pharmacodynamics (PD). Here we improved an model apt for PD studies by optimizing the vitro culture conditions enterococci. The vancomycin (VAN), ampicillin-sulbactam (SAM), piperacillin-tazobactam (TZP) against were determined vivo, comparing following different inoculum preparation: aerobiosis, aerobiosis plus mucin, anaerobiosis mucin. Drug exposure was expressed as ratio...
Describir las características clínicas, los esquemas de antibiótico empleados y el pronóstico en términos mortalidad intrahospitalaria efectos adversos pacientes con bacteriemia por enterobacterias prueba fenotípica para carbapenemasas positiva. Estudio corte trasversal un hospital tercer nivel (Medellín, Colombia), resistentes a carbapenems (CRE) detectados entre enero del 2010 diciembre 2013. Se presentan variables continuas medianas rangos intercuartiles (RIQ) categóricas porcentajes....
<p class="p1"><span class="s1"><strong> Resumen</strong>. </span>En este artículo, se reportan los resultados sobre las concepciones del infinito que prevalecen en estudiantes de la Licenciatura Matemáticas Universidad Autónoma Guerrero, México cuando enfrentan a procesos infinitos. Se hace un estudio explicativo-descriptivo diferentes acepciones más utilizadas nivel y particular, como elemento refuerzo teórico, asumimos proceso tiene situación límite si existe...
To analyze the prognostic role of positive cultures in patients with sepsis.A prospective cohort study a tertiary referral hospital Medellín, Colombia. Adults older than 18 years age bacterial infection diagnosis according to Centers for Disease Control criteria and sepsis (evidence organ dysfunction) were included. A logistic regression model was used determine association between mortality, Cox competing risk modeling approach stay as well secondary infections.Overall, 408 had cultures,...