A5021614142- COVID-19 Clinical Research Studies
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Neutropenia and Cancer Infections
- Public Health in Brazil
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Antibiotic Use and Resistance
- Respiratory viral infections research
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Herpesvirus Infections and Treatments
- Tuberculosis Research and Epidemiology
- HIV/AIDS drug development and treatment
- Hematopoietic Stem Cell Transplantation
- HIV/AIDS Research and Interventions
- Streptococcal Infections and Treatments
- Mosquito-borne diseases and control
- Healthcare Regulation
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV Research and Treatment
- Cystic Fibrosis Research Advances
- Ear Surgery and Otitis Media
- Urinary Tract Infections Management
- Poxvirus research and outbreaks
Lebanese American University
2023
Universidade Federal do Paraná
2009-2022
Hospital Nossa Senhora das Graças
2002-2022
Hospital de Clínicas Universidade Federal do Paraná
2017
Medico
2012
Universidade de São Paulo
2002
Universidade Federal de São Paulo
2002
Ceftaroline, the active form of prodrug ceftaroline fosamil, is a novel cephalosporin with bactericidal activity against important pathogens associated community-acquired pneumonia (CAP), including Streptococcus pneumoniae and common Gram-negative pathogens. FOCUS 1 randomized, double-blinded, Phase III study that was conducted to evaluate efficacy safety fosamil in treating patients CAP. The primary objective determine non-inferiority [lower limit 95% confidence interval (CI) ≥ −10%]...
Candida infections account for 80% of all fungal in the hospital environment, including bloodstream, urinary tract and surgical site infections. Bloodstream are now a major challenge tertiary hospitals worldwide due to their high prevalence mortality rates. The incidence candidemia public Brazil is approximately 2.5 cases per 1000 admissions. Due importance this infection, authors provide review diversity genus its clinical relevance, therapeutic options discuss treatment caused by Candida....
Different therapies are currently used, considered, or proposed for the treatment of COVID-19; many those therapies, no appropriate assessment effectiveness and safety was performed. This document aims to provide scientifically available evidence-based information in a transparent interpretation, subsidize decisions related pharmacological therapy COVID-19 Brazil.A group 27 experts methodologists integrated task-force formed by professionals from Brazilian Association Intensive Care Medicine...
Urinary tract infection (UTI) is a common condition in women. There an increased concern on reduction of bacterial susceptibility resulting from wrongly prescribing antimicrobials. This paper summarizes the recommendations four Brazilian medical societies (SBI – Society Infectious Diseases, FEBRASGO Federation Gynecology and Obstetrics Associations, SBU Urology, SBPC/ML Clinical Pathology/Laboratory Medicine) management urinary Asymptomatic bacteriuria should be screened at least twice...
Long-term potent activity of antiretrovirals is essential for HIV-1-infected, treatment-experienced patients. TITAN (TMC114/r In Treatment-experienced pAtients Naive to lopinavir) compared Week-96 efficacy and safety darunavir/ritonavir (DRV/r) versus lopinavir/ritonavir (LPV/r). Treatment-experienced, LPV-naïve, HIV-1-infected patients were randomised DRV/r 600/100 mg bid or LPV/r 400/100 plus optimised background regimen (≥ 2 NRTIs/NNRTIs). 595 enrolled (mean baseline HIV-1 RNA: 4.30 log10...
Candidemia is the main invasive fungal disease among hospitalized patients. Several breakthrough candidemia (BrC) cases have been reported, but few studies evaluate epidemiology, risk factors, molecular characterization, antifungal susceptibility profile and outcome of those patients, especially in developing countries including patients using broad spectrum antifungals. We conducted a retrospective study from 2011 to 2016, aged 12 years or older with candidemia. Epidemiological...
O diabetes mellitus (DM) é uma doença de alta prevalência nas sociedades modernas, na maioria das vezes com tratamento inadequado ou ausente. Apesar geralmente considerado como fator risco independente para ocorrência e gravidade infecções em geral, o DM não apresenta evidência clínica forte sua relação infecção. Observa-se, porém, maior certas pacientes DM, curso menos favorável algumas delas. Há também tipos infecção quase exclusivos DM. Experimentalmente, observa-se depressão da atividade...
Several therapies are being used or proposed for COVID-19, and many lack appropriate evaluations of their effectiveness safety. The purpose this document is to develop recommendations support decisions regarding the pharmacological treatment patients hospitalized with COVID-19 in Brazil.
Invasive aspergillosis (IA) currently is an important cause of mortality in subjects undergoing hematopoietic stem cell transplants (HSCT) and also opportunistic respiratory disseminated infections other types immunocompromised patients. We examined the medical records 24 cases proven probable invasive at Hospital de Clinicas Federal University Parana, Brazil, from January 1996 to October 2006. During this period occurred a mean 2.2 per year or 3.0 100 HSTC transplants. There was significant...
Gram-negative bacilli (GNB), notably Acinetobacter spp., Pseudomonas and Klebsiella are becoming increasingly resistant to carbapenems associated with high health care costs mortality, a global concern.
<h2>Abstract</h2> Invasive fungal disease (IFD) shows distinct regional incidence patterns and epidemiological features depending on the geographic region. We conducted a prospective survey in eight centres Brazil from May 2007 to July 2009. All haematopoietic cell transplant (HCT) recipients patients with acute myeloid leukaemia (AML) or myelodysplasia (MDS) were followed admission until 1 year end of consolidation therapy (AML/MDS). The 12-month cumulative (CI) proven probable IFD was...
Antiretroviral therapy (ART) has reduced morbidity and mortality related to human immunodeficiency virus (HIV) infection, but in spite of this advance, HIV mutations decrease antiretroviral susceptibility, thus contributing treatment failure patients. Genotyping HIV-1 allows the selection new drugs after initial drug failure. This study evaluated genotypic profile isolates from treated (drug-experienced) patients Paraná, Brazil. The prevalence reverse transcriptase (RT) protease (PR) genes...
A infecção em receptores de transplante células-tronco hematopoéticas (TCTH) está relacionada a altas taxas morbidade e mortalidade. O tipo transplante, fonte célula-tronco hematopoética, utilização doadores alternativos outras medidas relacionadas ao procedimento influenciam diretamente no na intensidade da imunossupressão, modificando o risco desenvolver uma infecção. Nesta seção são discutidas as estratégias para monitorização, diagnóstico tratamento das infecções TCTH três fases: fase...
Community-Acquired Pneumonia (CAP) is a major public health problem. In Brazil it has been estimated that 2,000,000 people are affected by CAP every year. Of those, 780,000 admitted to hospital, and 30,000 have death as the outcome. This an open-label, non-comparative study with purpose of evaluating efficacy, safety, tolerability levels IV azithromycin (IVA) ceftriaxone (IVC), followed oral (OA) for treatment inpatients mild severe CAP. Eighty-six patients (mean age 56.6 ± 19.8) were...
To estimate acute otitis media incidence among young children and impact on quality of life parents/caregivers in a southern Brazilian city.Prospective cohort study including 0-5 years age registered at private pediatric practice. Acute episodes diagnosed by pediatrician were assessed during 12-month follow-up.During September 2008-March 2010, 1,136 enrolled the study, 1074 (95%) followed: 55.0% ≤2 age, 52.3% males, 94.7% white, 69.2% had previously received pneumococcal vaccine clinics. per...