A5006309328- Antibiotic Use and Resistance
- SARS-CoV-2 and COVID-19 Research
- Patient Satisfaction in Healthcare
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Bacterial Identification and Susceptibility Testing
- Respiratory viral infections research
- Urinary Tract Infections Management
- COVID-19 epidemiological studies
- Bacterial Infections and Vaccines
- SARS-CoV-2 detection and testing
- COVID-19 and Mental Health
- Healthcare Systems and Technology
- COVID-19 and healthcare impacts
- Streptococcal Infections and Treatments
- COVID-19 Impact on Reproduction
- Pharmaceutical Practices and Patient Outcomes
- Infection Control and Ventilation
- Geriatric Care and Nursing Homes
- Nosocomial Infections in ICU
- Long-Term Effects of COVID-19
- Viral gastroenteritis research and epidemiology
- Sepsis Diagnosis and Treatment
Public Health Ontario
2016-2025
University of Toronto
2016-2025
St Joseph's Health Centre
2017-2025
3M (United States)
2016-2025
Unity Health Toronto
2019-2025
Institute for Clinical Evaluative Sciences
2015-2024
Health Net
2020-2023
Sunnybrook Health Science Centre
2017-2023
Health Sciences Centre
2017-2023
St. Michael's Hospital
2021-2023
Acute myocardial infarction can be triggered by acute respiratory infections. Previous studies have suggested an association between influenza and infarction, but those used nonspecific measures of infection or study designs that were susceptible to bias. We evaluated the laboratory-confirmed infarction.
OVERVIEW:Business model innovation is vital to sustaining open innovation. External technology partnerships allow business models accomplish even more. One important mechanism for innovating one's through establishing co-development relationships. The proper character of these relationships varies, depending on the context relationship. To sustain relationships, one must carefully define objectives and align each firm. should also determine whether various R&D capabilities are core, critical...
Abstract Objective To estimate the effectiveness of mRNA covid-19 vaccines against symptomatic infection and severe outcomes (hospital admission or death). Design Test negative design study. Setting Ontario, Canada between 14 December 2020 19 April 2021. Participants 324 033 community dwelling people aged ≥16 years who had symptoms were tested for SARS-CoV-2. Interventions BNT162b2 (Pfizer-BioNTech) mRNA-1273 (Moderna) vaccine. Main outcome measures Laboratory confirmed SARS-CoV-2 by reverse...
The incidence of SARS-CoV-2 infection, including among individuals who have received 2 doses COVID-19 vaccine, increased substantially following the emergence Omicron variant in Ontario, Canada. Understanding estimated effectiveness or 3 vaccine against outcomes associated with and Delta infections may aid decision-making at individual population levels.To estimate (VE) symptomatic due to variants severe (hospitalization death) these infections.This test-negative case-control study used...
Nursing home residents have been disproportionately affected by coronavirus disease 2019 (COVID-19). Prevention recommendations emphasize frequent testing of health care personnel and residents, but additional strategies are needed.
The role of remdesivir in the treatment patients hospital with COVID-19 remains ill defined a global context. World Health Organization Solidarity randomized controlled trial (RCT) evaluated across many countries, Canada enrolling using an expanded data collection format Canadian Treatments for (CATCO) trial. We report on findings, additional demographics, characteristics and clinical outcomes, to explore potential differential effects different health care systems.
ABSTRACT SARS-CoV-2 variants of concern (VOC) are more transmissible and have the potential for increased disease severity decreased vaccine effectiveness. We estimated effectiveness BNT162b2 (Pfizer-BioNTech Comirnaty), mRNA-1273 (Moderna Spikevax), ChAdOx1 (AstraZeneca Vaxzevria) vaccines against symptomatic infection COVID-19 hospitalization or death caused by Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2) VOCs in Ontario, Canada using a test-negative design study....
As a result of low numbers pediatric cases early in the COVID-19 pandemic, household transmission SARS-CoV-2 remains an understudied topic.
ABSTRACT Background The incidence of SARS-CoV-2 infection, including among those who have received 2 doses COVID-19 vaccines, increased substantially following the emergence Omicron in Ontario, Canada. Methods Applying test-negative study design to linked provincial databases, we estimated vaccine effectiveness (VE) against symptomatic infection and severe outcomes (hospitalization or death) caused by Delta between December 6 26, 2021. We used multivariable logistic regression estimate 3...
Bloodstream infections (BSIs) represent a substantial mortality risk, yet most studies are limited to select pathogens or populations. The aim of this study was describe the population-wide prevalence BSIs and examine associated risk for responsible microorganisms. We conducted retrospective cohort in Ontario 2017. Blood culture data collected from almost all microbiology laboratories linked sets patient characteristics. For each organism, we determined crude using logistic regression...
<h3>Background:</h3> A randomized controlled trial involving a high-risk, unvaccinated population that was conducted before the Omicron variant emerged found nirmatrelvir–ritonavir effective in preventing progression to severe COVID-19. Our objective evaluate effectiveness of COVID-19 while and its subvariants predominate. <h3>Methods:</h3> We population-based cohort study Ontario included all residents who were older than 17 years age had positive polymerase chain reaction test for...
<h3>Background:</h3> A resurgence of pertussis cases among both vaccinated and unvaccinated people raises questions about vaccine effectiveness over time. Our objective was to study the characterize effect waning immunity whole-cell priming. <h3>Methods:</h3> We used test-negative design, a nested case–control with individuals as controls. constructed multivariable logistic regression models estimate odds ratios (ORs). Vaccine calculated (1 – OR) × 100. assessed by calculating developing per...
Abstract Background Antibiotic use is the strongest modifiable risk factor for development of Clostridioides difficile infection, but prescribers lack quantitative information on comparative risks specific antibiotic courses. Our objective was to estimate C. infection associated with receipt Methods We conducted a longitudinal case-cohort analysis representing over 90% Ontario nursing home residents, between 2012 and 2017. primary exposure days in prior 90 days. Adjustment covariates...
To estimate the effectiveness of maternal mRNA covid-19 vaccination during pregnancy against delta and omicron severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection hospital admission in infants.Test negative design study.Community testing Ontario, Canada.Infants younger than six months age, born between 7 May 2021 31 March 2022, who were tested for SARS-CoV-2 5 September 2022.Maternal pregnancy.Laboratory confirmed or infant. Multivariable logistic regression estimated...
Abstract We estimated the effectiveness of booster doses monovalent mRNA COVID-19 vaccines against Omicron-associated severe outcomes among adults in Ontario, Canada. used a test-negative design to estimate vaccine (VE) hospitalization or death SARS-CoV-2-tested aged ≥50 years from January 2 October 1, 2022, stratified by age and time since vaccination. also compared VE during BA.1/BA.2 BA.4/BA.5 sublineage predominance. included 11,160 cases 62,880 tests for controls. Depending on group,...
Importance The study team previously showed that maternal mRNA COVID-19 vaccination during pregnancy confers protection against SARS-CoV-2 infection and COVID-19–related hospital admission in newborns young infants. In this study, the evaluated newborn early infant safety outcomes following messenger RNA (mRNA) pregnancy, for which there is limited comparative epidemiological evidence. Objective To determine if associated with adverse outcomes. Design, Setting, Participants This...
Antibiotic duration is often longer than necessary. Understanding the reasons for variability in antibiotic can inform interventions to reduce prolonged use. We aim describe patterns of interphysician prescribed treatment durations and determine physician predictors community setting.We performed a retrospective cohort analysis family physicians Ontario, Canada, between 1 March 2016 28 February 2017, using Xponent dataset from IQVIA. The primary outcome was proportion course prescribed,...
<h3>Background:</h3> Unnecessary antibiotic use in the community Canada is not well defined. Our objective was to quantify unnecessary prescribing a Canadian primary care setting. <h3>Methods:</h3> We performed descriptive analysis Ontario from April 2011 March 2016 using Electronic Medical Records Primary Care database linked other health administrative data sets at ICES. determined rates (per 100 patient–physician encounters) for 23 common conditions and estimated of predefined expected...
ABSTRACT Objectives To estimate the effectiveness of mRNA COVID-19 vaccines against symptomatic infection and severe outcomes. Design We applied a test-negative design study to linked laboratory, vaccination, health administrative databases, used multivariable logistic regression adjusting for demographic clinical characteristics associated with SARS-CoV-2 vaccine receipt (VE) Setting Ontario, Canada between 14 December 2020 19 April 2021. Participants Community-dwelling adults aged ≥16...