Alexandra Binnie
A5022253285- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- COVID-19 and healthcare impacts
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Cancer Genomics and Diagnostics
- Intensive Care Unit Cognitive Disorders
- SARS-CoV-2 and COVID-19 Research
- Nutrition, Genetics, and Disease
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
- Health Sciences Research and Education
- Genomics and Rare Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Immune responses and vaccinations
- Health and Medical Research Impacts
- COVID-19 and Mental Health
- Histone Deacetylase Inhibitors Research
- SARS-CoV-2 detection and testing
- Ethics in Clinical Research
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare professionals’ stress and burnout
- Primary Care and Health Outcomes
- Healthcare cost, quality, practices
- Antibiotic Use and Resistance
William Osler Health System
2019-2025
Algarve Biomedical Center
2016-2025
Humber College
2025
University of Algarve
2016-2024
University of Toronto
1999-2024
Sunnybrook Health Science Centre
2023-2024
North York General Hospital
2024
Monash Medical Centre
2024
University Health Network
2024
London Health Sciences Centre
2024
The role of remdesivir in the treatment patients hospital with COVID-19 remains ill defined a global context. World Health Organization Solidarity randomized controlled trial (RCT) evaluated across many countries, Canada enrolling using an expanded data collection format Canadian Treatments for (CATCO) trial. We report on findings, additional demographics, characteristics and clinical outcomes, to explore potential differential effects different health care systems.
<h3>Importance</h3> Growing interest in microbial dysbiosis during critical illness has raised questions about the therapeutic potential of microbiome modification with probiotics. Prior randomized trials this population suggest that probiotics reduce infection, particularly ventilator-associated pneumonia (VAP), although probiotic-associated infections have also been reported. <h3>Objective</h3> To evaluate effect of<i>Lactobacillus rhamnosus</i>GG on preventing VAP, additional infections,...
Whether proton-pump inhibitors are beneficial or harmful for stress ulcer prophylaxis in critically ill patients undergoing invasive ventilation is unclear.
Breast cancer is a highly heterogeneous disease resulting in diverse clinical behaviours and therapeutic responses. DNA methylation major epigenetic alteration that commonly perturbed cancers. The aim of this study to characterize the relationship between aberrant gene expression breast cancer. We analysed profiles from tissue matched normal Cancer Genome Atlas (TCGA). Genome-wide differential analysis methylation-gene correlation was performed. Gene changes were subsequently validated...
To accommodate the unprecedented number of critically ill patients with pneumonia caused by coronavirus disease 2019 (COVID-19) expansion capacity intensive care unit (ICU) to clinical areas not previously used for critical was necessary. We describe global burden COVID-19 admissions and organizational characteristics associated outcomes in patients.Multicenter, international, point prevalence study, including adult SARS-CoV-2 infection confirmed polymerase chain reaction (PCR) a diagnosis...
The COVID-19 pandemic presented major challenges for critical care facilities worldwide. Infections which develop alongside or subsequent to viral pneumonitis are a challenge under sporadic and conditions; however, data have suggested that patterns of these differ between other pneumonitides. This secondary analysis aimed explore co-infection intensive unit-acquired infections (ICU-AI) the relationship use corticosteroids in large, international cohort critically ill patients.
Blood collection for laboratory testing in intensive care unit (ICU) patients is a modifiable contributor to anemia and red blood cell (RBC) transfusion. Most withdrawn not required analysis discarded.
Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment uncertain.
Recent evidence from the fields of microbiology and immunology, as well a small number human sepsis studies, suggest that epigenetic regulation may play central role in pathogenesis sepsis. The term "epigenetics" refers to regulatory mechanisms control gene expression but are not related changes DNA sequence. These include methylation, histone modifications, transcription via non-coding RNAs. Epigenetic occurring response external stressors, lead expression, thus lie at intersection between...
Epigenetic alterations are an important regulator of gene expression in health and disease; however, epigenetic data sepsis lacking. To demonstrate proof concept estimate effect size, we performed the first epigenome-wide methylation analysis whole blood DNA samples from a cohort septic nonseptic critically ill patients.
Intensive care unit healthcare workers (ICU HCW) are at risk of mental health issues during emerging disease outbreaks. A study ICU HCW from France revealed symptoms anxiety and depression in 50.4% 30.4% the peak first wave pandemic. The level COVID-19 exposure these was very high. In Canada, experienced variable to pandemic, with some hospitals seeing large numbers patients while others saw few or none. this we examined relationship between Canadian HCW. We conducted a cross-sectional...
Few surveys have focused on physician moral distress, burnout, and professional fulfilment. We assessed wellness coping during the COVID-19 pandemic.
Canada's clinical research landscape is limited by minimal community hospital engagement. However, participation in hospitals may increase the speed of trial enrolment, enhance generalizability results and accelerate knowledge translation to hospitals, where most Canadians receive care. Two identified barriers are financial support a lack mentorship. This study an intrinsic descriptive case describing impact 1 year funding from Canadian Critical Care Trials Group (CCCTG) creation practice on...
KEY POINTS The traditional setting of health research is academic centres.[1][1],[2][2] However, Canadian care could benefit from conducted and started in centres where most the population receives with substantial potential to conduct research: community hospitals.[3][3]
Intensive care unit healthcare workers (ICU HCW) are at risk of mental health disorders during emerging disease outbreaks. Numerous cross-sectional studies have reported psychological distress, anxiety, and depression amongst ICU HCW the COVID-19 pandemic. However, few followed longitudinally, none these examined association between workload health. We conducted a longitudinal cohort study 309 Canadian from April 2020 to August 2020, 1 st wave Psychological distress was assessed using...
Abstract Background The COVID-19 pandemic has precipitated rapid changes in medical education to protect students and patients from the risk of infection. Virtual Patient Simulators (VPS) provide a simulated clinical environment which can interview examine patient, order tests exams, prioritize interventions, observe response therapy, all with minimal themselves their patients. Like high-fidelity simulators (HFS), VPS are tool improve curricular integration. Unlike HFS, require limited...