A5048144412- Long-Term Effects of COVID-19
- Anesthesia and Neurotoxicity Research
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- COVID-19 and healthcare impacts
- Vitamin C and Antioxidants Research
- Blood transfusion and management
- Nosocomial Infections in ICU
- Anesthesia and Sedative Agents
- Appendicitis Diagnosis and Management
- Medicinal Plants and Neuroprotection
- Cleft Lip and Palate Research
- Vitamin D Research Studies
- Child and Adolescent Health
- Amoebic Infections and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Childhood Cancer Survivors' Quality of Life
- Pediatric Pain Management Techniques
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Thermal Regulation in Medicine
- Medical and Biological Ozone Research
- Heart Failure Treatment and Management
- Antibiotic Use and Resistance
University of Split
2006-2024
Klinički Bolnički Centar Split
2018-2022
To accommodate the unprecedented number of critically ill patients with pneumonia caused by coronavirus disease 2019 (COVID-19) expansion capacity intensive care unit (ICU) to clinical areas not previously used for critical was necessary. We describe global burden COVID-19 admissions and organizational characteristics associated outcomes in patients.Multicenter, international, point prevalence study, including adult SARS-CoV-2 infection confirmed polymerase chain reaction (PCR) a diagnosis...
The COVID-19 pandemic presented major challenges for critical care facilities worldwide. Infections which develop alongside or subsequent to viral pneumonitis are a challenge under sporadic and conditions; however, data have suggested that patterns of these differ between other pneumonitides. This secondary analysis aimed explore co-infection intensive unit-acquired infections (ICU-AI) the relationship use corticosteroids in large, international cohort critically ill patients.
COVID-19 symptoms vary from asymptomatic cases to moderate and severe illness with patients needing hospitalization intensive care treatment. Vitamin D is associated severity of viral infections has an immune-modulatory effect in immune response. Observational studies showed a negative association low vitamin levels mortality outcomes. In this study, we aimed determine whether daily supplementation during unit (ICU) stay affects clinically relevant Patients disease need respiratory support...
Purpose: To investigate the quality of life (QoL) survivors from severe forms COVID-19 treated in ICU. Methods: In this study, we investigated QoL patients with ICU November 2021 to February 2022. study period, 288 were and 162 alive at time analysis. Of those, 113 included study. was analyzed 4 months after admission using EQ-5D-5L questionnaire administered by telephone. Results: surviving patients, 46% reported moderate problems anxiety/depression domain, 37% had usual activities, 29%...
BACKGROUND Negative postoperative behavioural changes (NPOBCs) are very frequent in children after surgery and general anaesthesia. If they persist, emotional cognitive development may be affected significantly. OBJECTIVE To assess whether the choice of different anaesthetic techniques for adenotonsillectomy impact upon incidence NPOBC repeated measurements. DESIGN A randomised, controlled, parallel-group trial. SETTING University Hospital Split, Croatia. PATIENTS Sixty-four (aged 6 to 12...
The effect of routine inhalation therapy on ventilator-associated pneumonia (VAP) in mechanically ventilated patients with the coronavirus disease (COVID-19) has not been well-defined. This randomized controlled trial included 175 eligible adult COVID-19 who were treated mechanical ventilation at University Hospital Split between October 2020 and June 2021. Patients allocated to a control group (no inhalation) or one treatment arms (inhalation N-acetylcysteine; 5% saline solution; 8.4%...
There are conflicting data about gender differences in short-term mortality after acute myocardial infarction (AMI) adjusting for age and other prognostic factors. Therefore, we investigated the risk profile, clinical presentation, in-hospital mechanisms of death women men first AMI.The were obtained from a chart review 3382 consecutive patients, 1184 (35%) (69.7+/-10.9 years) 2198 (65%) (63.5+/-11.8 with AMI. The effect its interaction age, factors thrombolytic therapy on overall examined...
Although the number of cases and mortality COVID-19 are seemingly declining, clinicians endeavor to establish indicators predictors such responses in order optimize treatment regimens for future outbreaks SARS-CoV-2 or similar viruses. Considering importance aberrant immune response severe COVID-19, present study, we aimed explore dynamic serum TNF-like weak inducer apoptosis (TWEAK) levels critically-ill patients whether these may predict in-hospital if TWEAK is associated with impairment...
Accumulating data suggest that various neurologic manifestations are reported in critically-ill COVID-19 patients. Although low testosterone levels were associated with poor outcomes, the relationship between and indices of brain injury still poorly understood. Therefore, we aimed to explore whether glial fibrillary acidic protein (GFAP) ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), biomarkers injury, patients a severe form COVID-19. The present study was conducted on 65 male aged 18−65...
Catestatin is a pleiotropic peptide with wide range of immunomodulatory effects. Considering that patients severe COVID-19 infection have major immunological dysregulation, the aim this study was to evaluate catestatin levels in treated intensive care unit (ICU) and compare them between fatal non-fatal outcomes. The included 152 COVID-19, out which 105 had outcome 47 outcome. Serum were estimated by an enzyme-linked immunosorbent assay commercially available diagnostic kit. results show...
Background: Coronavirus disease 2019 (COVID-19) is an infectious caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Although it known that the COVID-19 distress (ARDS) associated with higher incidence of pulmonary barotrauma, unique mechanisms causing aforementioned complication are still to be investigated. The goal this research was investigate barotrauma among patients treated in intensive care unit (ICU) and examine different clinical outcomes those subjects.
After the outbreak in China year 2019, severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) quickly spread around world causing a protracted pandemic. Approximately one-third of infections appear to be asymptomatic. Symptomatic disease is characterized primarily by symptoms tract infection varying severity. But Disease 2019 (COVID-19) much more than an because SARS-CoV-2 affects many organs inducing vast number such as cardiovascular, neurological, gastrointestinal, dermatological,...
In hip fracture patients, who are mostly elderly, preexisting anemia can be worsened when combined with trauma and surgery. To this date, there is no unequivocal approach about transfusion thresholds. We analyzed hemoglobin (Hb) hematocrit (Hct) levels at three time points in surgical patients proximal femoral fractures (PFF) to see which were triggers for transfusions whether related mortality after hospital discharge. A total of 956 operated on from 1 January 2021 31 December 2022 the...
BACKGROUND: Observational studies showed the association of low levels vitamin D with COVID-19 susceptibility, severity and mortality outcomes. Vitamin D, so called "sun in a bottle," is known to have immuno-modulatory effects. The main goal this observational study was see if there possible connection between various clinical outcomes patients need respiratory support admitted Intensive Care Unit (ICU) from November 2021 April 2022.METHODS: On admission, were measured, divided into two...
Tonsillectomy is one of the most common operative procedures in childhood. According to Croatian national guidelines for treatment sore throat (ISKRA guidelines), apsolute indications tonsillectomy are recurrent tonsillitis (>4 per year) and sleep disordered breathing (including snoring obstructive apnea). Most children Croatia undergo conventional cold steel with bipolar diathermy coagulation using reusable surgical accessories. Estimated blood loss during this type surgery about 10%...
COVID-19 presentations range from cold-like symptoms to severe with the development of acute respiratory distress syndrome (ARDS). We report on a patient who was mechanically ventilated and developed ARDS bacterial infection. Because rapid clinical deterioration exhaustion other treatment options, family attending physicians requested compassionate use adult allogenic bone marrow-derived mesenchymal stem cells (MSC) in addition commonly used immunosuppressive, antiviral, supportive therapy....
Klostridijska plinska gangrena je brzo šireća nekrotična infekcija mekog tkiva s visokim smrtnim isho-