A5040585052- Renal and related cancers
- Connexins and lens biology
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Genetic and Kidney Cyst Diseases
- Birth, Development, and Health
- Renal Diseases and Glomerulopathies
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Neonatal Respiratory Health Research
- Cell death mechanisms and regulation
- Chronic Kidney Disease and Diabetes
- dental development and anomalies
- Pain Mechanisms and Treatments
- Pancreatic function and diabetes
- Pregnancy and preeclampsia studies
- Genetic factors in colorectal cancer
- Proteoglycans and glycosaminoglycans research
- Health and Medical Research Impacts
- Tissue Engineering and Regenerative Medicine
- Neurogenesis and neuroplasticity mechanisms
- Osteoarthritis Treatment and Mechanisms
- Reproductive System and Pregnancy
- Drug-Induced Hepatotoxicity and Protection
- Digestive system and related health
University of Split
2016-2025
University of Mostar
2016-2025
Mediterranean Institute for Life Sciences
2022-2025
Columbia University Irving Medical Center
2023
University of Antwerp
2023
John Wiley & Sons (United States)
2023
Liechtenstein Institute
2023
Hudson Institute
2023
Columbia University
2014-2015
The DiGeorge syndrome, the most common of microdeletion syndromes, affects multiple organs, including heart, nervous system, and kidney. It is caused by deletions on chromosome 22q11.2; genetic driver kidney defects unknown.
Congenital abnormalities of the kidney and urinary tract are most common cause pediatric failure. These disorders highly heterogeneous, etiologic factors poorly understood.We performed genomewide linkage analysis whole-exome sequencing in a family with an autosomal dominant form congenital or (seven affected members). We also sequence 311 unrelated patients, as well histologic functional studies.Linkage identified five regions genome that were shared among all members. Exome single, rare,...
An association between dental fear and anxiety (DFA) has been confirmed for children younger than 8 years, but this in older is less clear. The aim of study was to fill knowledge gap by studying DFA their parents with validated measures. This cross-sectional study, conducted at Community Health Centre Mostar, Bosnia Herzegovina, included 114 parents. DFA, coping, sociodemographic variables were studied using Corah Dental Anxiety Questionnaire (CDAS), Subscale the Children's Fear Survey...
Background and objectives: The epithelial stromal tissues both play a role in the progression of colorectal cancer (CRC). aim this study was to assess expression anti-apoptotic Bcl-2 pro-apoptotic Bax epithelium as well lamina propria normal colonic controls, low-grade tumor samples high-grade samples. Materials Methods: A total 60 consisting carcinoma collected from Department Pathology, Cytology Forensic Medicine, University Hospital Center, Split January 2020 December 2021. markers...
Kidney failures in infants are mostly caused by congenital anomalies of the kidney and urinary tract (CAKUT), which among most common birth disorders worldwide when paired with cardiac abnormalities. People CAKUT often have severe failure as a result wide range abnormalities that can occur alone or conjunction other syndromic disorders. In this study, we aimed to investigate expression pattern candidate genes alpha-8 integrin (ITGA8) Van Gogh-like 2 (VANGL2) fetal tissues healthy...
Healthy and controlled immune response in COVID-19 is crucial for mild forms of the disease. Although CD8+ T cells play important role this response, there still a lack studies showing gene expression profiles those at beginning disease as potential predictors more severe after first week. We investigated proportion different subpopulations their patterns cytotoxic proteins (perforin-1 (PRF1), granulysin (GNLY), granzyme B (GZMB), A (GZMA), K (GZMK)), cytokine interferon-γ (IFN-γ), apoptotic...
Colorectal cancer (CRC) remains a significant health burden, and its delayed diagnosis at advanced stages leads to poor survival outcome. Detection of known novel prognostic markers is essential. In this study, the status likely markers-the apoptotic inducing factor (AIFM3), vestigial-like family member 4 (VGLL4), WNT4-was evaluated. AIFM3, VGLL4, WNT4 expression in CRC tissues across different (Dukes A-D) were analyzed using histological immunofluorescence staining RNA sequencing analyses....
Background: The main feature of osteoarthritis (OA) is the deterioration articular cartilage, but numerous studies have demonstrated role synovial inflammation in early stages disease, leading to further progression OA. WNT signaling pathway involved activities joint tissue, there a lack evidence considering OA synovitis. Our research aims investigate expression Family Member 5A/B (WNT5A/B), β-catenin, acetyl-α-tubulin, Dishevelled-1 (DVL-1), and Inversin (INV) membrane hips. Methods:...
Background/Objectives: The human kallikrein-related peptidase 6 (KLK6), a serine protease with trypsin-like properties, belongs to the 15-member kallikrein (KLK) gene family and is predominantly recognized for its role in oncogenesis, neurodegenerative disorders, skin conditions. Aquaporins (AQPs) are integral membrane proteins that facilitate water transport across cell membranes. AQP1 constitutively active kidneys plays crucial reabsorbing filtered water, while AQP2 regulated by...
UBASH3A and UBASH3B are protein families of atypical tyrosine phosphatases that function as regulators various cellular processes during mammalian development. As has only mild phosphatase activity, its regulatory effects based on the phosphatase-independent mechanisms. On contrary, strong suppression receptor signalling is mediated by Syk Zap-70 kinases. The functions particularly evident in lymphoid tissues kidney These also known to play key roles autoimmunity neoplasms. However, their...
The purpose of this study was to evaluate the effects Dab1 gene silencing on immunoexpression light chain 3 beta (Lc3b), glucose regulating protein 78 (Grp78), heat shock cognate 71 (Hsc70), mammalian target rapamycin (mTOR) and lysosomal-associated membrane 2A (Lamp2a) in lung tissue developing yotari (Dab1−/−) wild-type (wt) mice. epithelium mesenchyme embryos at gestational days E13.5 E15.5 were examined using immunofluorescence semi-quantitative methods. In pulmonary epithelium, Grp78...
Background: The recognition of comorbidities is relevant for asthma management, especially if these conditions/diseases are treatable traits such as anxiety. This study aimed to explore the associations between severity and child parent asthma-related anxiety recognize most common specific fears. Methods: cross-sectional consisted 150 parents their children diagnosed with asthma, was conducted at Pediatric Clinic University Hospital Center Split in Croatia. All children, from ages 3 17...
Background: The aim of this study was to investigate treatment outcomes in adolescents who underwent laparoscopic surgery with an ultrasonic scalpel for symptomatic varicocele compared a polymer clip. Methods: A total 270 median age 16 (interquartile range, IQR 13–17) years were included the study. Taking into account varicocelectomy technique used, patients divided two groups. In first group (n = 151), clip while second 119), used resect spermatic vessels. primary outcome measure effect on...
Background:In a healthy kidney, contractile protein alpha-smooth muscle actin (ASMA) is immunohistochemically strongly expressed only in the blood vessels, while pathological conditions it can be visualized glomerular mesangial cells and interstitial myofibroblasts. The aim of this study was to explore possible correlation between expression ASMA glomerulonephritis (GN) indicators renal function.Material/Methods:We analyzed percutaneous biopsy 142 adult pediatric patients with GN its...
Synovitis of the knee synovium is proven to be a precursor osteoarthritis (OA), leading radiologically advanced stage disease. This study was conducted elucidate expression pattern different inflammatory factors—NF-kB, iNOS, and MMP-9 in subpopulation synovial cells. Thirty membrane intra-operative biopsies patients (ten controls, ten with early OA, according Kellgren–Lawrence radiological score) were immunohistochemically stained for NF-kB, MMP9, cell markers macrophages, fibroblasts,...
One major challenge during the COVID-19 pandemic was limited accessibility to healthcare facilities, especially for older population. The aim of current study exploration extent which systems responded needs people with or without cognitive impairment and their caregivers in Adrion/Ionian region. Data were collected through e-questionnaires regarding adequacy system anonymously administered individuals stakeholder providers following countries: Slovenia, Italy (Calabria), Croatia, Bosnia...
The purpose of this study was to compare the immunofluorescence patterns autophagic markers: Light chain 3 beta (LC3B), Glucose regulating protein 78 (GRP78), Heat shock cognate 71 (HSC70) and Lysosomal-associated membrane 2A (LAMP2A) in developing postnatal kidneys Dab1-/- (yotari) mice those wild-type samples. Embryos were obtained on gestation days 13.5 15.5 (E13.5 E15.5), adult animals sacrificed at 4, 11 14 (P4, P11, P14). After fixation dehydration, paraffin-embedded kidney tissues...
AimTo assess awareness and use of evidence-based medicine (EBM) databases The Cochrane Library among physicians in Croatia.MethodsA cross-sectional study with a telephone survey was performed 573 (88.6% response rate from 647 contacted physicians) family practice 4 major university hospital centers Croatia. main outcome measures were physicians' Collaboration, Library, access to EBM databases, internet at work.ResultsOverall, 54% respondents said they had but when asked which used, named...