A5080291040- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Pediatric Urology and Nephrology Studies
- Renal Diseases and Glomerulopathies
- Biomedical Research and Pathophysiology
- Renal and related cancers
- Birth, Development, and Health
- Acute Kidney Injury Research
- Childhood Cancer Survivors' Quality of Life
- Renal function and acid-base balance
- Metabolism and Genetic Disorders
- Blood Pressure and Hypertension Studies
- Urological Disorders and Treatments
- Ion Transport and Channel Regulation
- Renal and Vascular Pathologies
- Cellular transport and secretion
- Immunodeficiency and Autoimmune Disorders
- Acute Lymphoblastic Leukemia research
- Kidney Stones and Urolithiasis Treatments
- Parathyroid Disorders and Treatments
- Ion channel regulation and function
- Neonatal Health and Biochemistry
- Amino Acid Enzymes and Metabolism
- Medical Imaging and Pathology Studies
- Chemotherapy-induced organ toxicity mitigation
Emma Kinderziekenhuis
2016-2025
Amsterdam University Medical Centers
2018-2025
Vrije Universiteit Amsterdam
2008-2025
University of Amsterdam
2021-2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
2011-2021
Uppsala University
2021
Amsterdam UMC Location University of Amsterdam
2016-2019
University Medical Center Groningen
2016
University of Groningen
2016
Vanderbilt University Medical Center
2014
Objectives. Serum creatinine is the most common endogenous marker of renal function. The proportionality between production and muscle mass requires adjustment for height body composition. low molecular weight protein cystatin C produced by all nucleated cells eliminated glomerular filtration. Therefore, was studied as an alternative filtration rate (GFR) in children. Methods. Cystatin were measured sera from inulin clearance (CIn) examinations performed 184 children aged 0.24 to 17.96...
Many different cystatin C-based equations exist for estimating glomerular filtration rate. Major reasons this are the previous lack of an international C calibrator and nonequivalence results from assays.Use recently introduced certified reference material, ERM-DA471/IFCC, further work to achieve high agreement equivalence 7 commercially available assays allowed a substantial decrease CV assays, as defined by their performance in external quality assessment clinical laboratory...
The Chronic Kidney Disease in Children Study (CKiD) equation for children and the Epidemiology Collaboration (CKD-EPI) adults are recommended serum creatinine (SCr)-based calculations estimating glomerular filtration rate (GFR). However, these equations, as well their combination, have limitations, notably problem of implausible changes GFR during transition from adolescence to adulthood overestimation young adults. full age spectrum (FAS) addresses issues but overestimates when SCr levels...
Background. Children with a solitary functioning kidney (SFK) have an increased risk of developing hypertension, albuminuria and chronic disease in later life. This renal injury is hypothesized to be caused by glomerular hyperfiltration that follows mass reduction animal studies. Furthermore, children SFK show high incidence congenital anomalies the urinary tract (CAKUT), which could further compromise function. Methods. A retrospective study markers was performed 206 children, divided into...
A new Chronic Kidney Disease Epidemiology Collaboration equation without the race variable has been recently proposed (CKD-EPIAS). This neither validated outside USA nor compared with European Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in cohorts.Standardized creatinine measured glomerular filtration rate (GFR) from EKFC cohorts (n = 13 856 including 6031 individuals external validation cohort), France 4429, 964 Black Europeans), Brazil 100) Africa 508)...
International consensus supports the development of standardized mGFR protocols to facilitate implementation more widespread and routine testing in clinical care research protocols. With support from EKFC, an international group experts performed extensive literature search develop recommendations for a approach determine mGFR. This paper evaluated evidence formulated that include all aspects iohexol plasma clearance measurement adults not on dialysis. These practical advice patient...
Lowe syndrome is defined by congenital cataracts, mental retardation, and proximal tubulopathy due to mutations in OCRL. Recently, OCRL were found underlie some patients with Dent disease, characterized low molecular weight proteinuria, hypercalciuria, nephrocalcinosis. This phenotypic heterogeneity poorly understood.The renal phenotype of 16 (10.9 +/- 7.0 yr) under care the authors was define overlap symptoms disease infer clues about function. Medical charts reviewed for data regarding...
According to the hyperfiltration hypothesis, a low nephron endowment will lead in remaining glomeruli and is associated with systemic hypertension, proteinuria glomerulosclerosis. Being born one functioning kidney instead of two, for instance because unilateral renal agenesis or multicystic dysplastic kidney, cause congenital mass reduction.In order study effect reduction on function blood pressure, retrospective chart review 66 patients at Pediatric Renal Center VU University Medical was...
Little is known about renal function and blood pressure (BP) in long-term childhood cancer survivors. This cross-sectional study evaluated prevalence of these outcomes associated risk factors survivors at their first visit to a specialized outpatient clinic.
Cystatin C, a cationic 13.3-kDa protein (1) has recently been described as promising endogenous marker of glomerular filtration rate (GFR) (2) in both adults (2)(3) and children (4)(5). Correlation serum cystatin C concentrations with the results inulin 51Cr-ethylenediaminetetraacetic acid clearance examinations was superior to creatinine (2)(3)(4). Although patients wide range renal function were examined, potential effect underlying disease on this correlation not studied yet. In recent...