A5025534035- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Birth, Development, and Health
- Cardiovascular Health and Disease Prevention
- Renal function and acid-base balance
- Acute Kidney Injury Research
- Alcohol Consumption and Health Effects
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Gout, Hyperuricemia, Uric Acid
- Pregnancy and preeclampsia studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Folate and B Vitamins Research
- Noise Effects and Management
- Asthma and respiratory diseases
- Retinal Imaging and Analysis
- Parathyroid Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Pediatric health and respiratory diseases
- Sodium Intake and Health
- Hormonal Regulation and Hypertension
UiT The Arctic University of Norway
2016-2025
University Hospital of North Norway
2016-2025
Renal Research Institute
2016-2017
Oslo University Hospital
2017
RELX Group (United States)
2016
Institute of Clinical Research
2012
Glomerular filtration rate (GFR) is accepted as the best indicator of kidney function and commonly estimated from serum creatinine (SCr)-based equations. Separate equations have been developed for children (Schwartz equation), younger middle-age adults [Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation] older [Berlin Initiative Study 1 (BIS1) equation], these lack continuity with ageing. We validated an equation estimating glomerular that can be used across full age...
The Chronic Kidney Disease in Children Study (CKiD) equation for children and the Epidemiology Collaboration (CKD-EPI) adults are recommended serum creatinine (SCr)-based calculations estimating glomerular filtration rate (GFR). However, these equations, as well their combination, have limitations, notably problem of implausible changes GFR during transition from adolescence to adulthood overestimation young adults. full age spectrum (FAS) addresses issues but overestimates when SCr levels...
We recently published and validated the new serum creatinine (Scr)-based full-age-spectrum equation (FAS crea ) for estimating glomerular filtration rate (GFR) healthy kidney-diseased subjects of all ages. The was based on concept normalized Scr shows equivalent to superior prediction performance currently recommended equations children, adolescents, adults older adults.Based an evaluation cystatin C (ScysC) distribution, we defined normalization constants ScysC ( Q cysC = 0.82 mg/L ages <70...
A reliable assessment of glomerular filtration rate (GFR) is paramount importance in clinical practice as well epidemiological and research settings. It recommended by Kidney Disease: Improving Global Outcomes guidelines specific populations (anorectic, cirrhotic, obese, renal non-renal transplant patients) where estimation equations are unreliable. Measured GFR the only valuable test to confirm or confute status chronic kidney disease (CKD), evaluate slope function decay over time, assess...
While there is general agreement on the necessity to measure glomerular filtration rate (GFR) in many clinical situations, less best method achieve this purpose. As gold standard for GFR determination, urinary (or renal) clearance of inulin, fades into background due inconvenience and high cost, a diversity markers protocols compete replace it. In review, we suggest that iohexol, non-ionic contrast agent, most suited inulin as marker choice determination. Iohexol comes very close fulfilling...
The accuracy of estimation kidney function with the use routine metabolic tests, such as measurement serum creatinine level, has been controversial. European Kidney Function Consortium (EKFC) developed a creatinine-based equation (EKFC eGFRcr) to estimate glomerular filtration rate (GFR) rescaled level (i.e., is divided by median among healthy persons control for variation related differences in age, sex, or race). Whether cystatin C-based EKFC would increase estimated GFR unknown. We used...
Increased glomerular filtration rate (GFR), also called hyperfiltration, is a proposed mechanism for renal injury in diabetes. The causes of hyperfiltration individuals without diabetes are largely unknown, including the possible role borderline hyperglycemia. We assessed whether impaired fasting glucose (IFG; 5.6-6.9 mmol/L), elevated HbA1c, or hyperinsulinemia associated with general middle-aged population.A total 1,560 individuals, aged 50-62 years diabetes, were included Renal Iohexol...
Estimation of the GFR (eGFR) using creatinine- or cystatin C-based equations is imperfect, especially when true normal near-normal. Modest reductions in eGFR from range variably predict cardiovascular morbidity. If associates not only with measured (mGFR) but also risk factors, effects these non-GFR-related factors might bias association between and outcome. To investigate potential associations we by iohexol clearance a sample general population (age 50 to 62 years) without known disease,...
CKD is more prevalent in women, but men receive kidney replacement therapy for failure. This apparent contradiction not well understood.We investigated sex differences the loss of function and whether any disparities could be explained by comorbidity or risk factors. In Renal Iohexol Clearance Survey (RENIS) northern Europe, we recruited 1837 persons (53% aged 50-62 years) representative general population without self-reported diabetes, CKD, cardiovascular disease. Participants' GFR was...
A new Chronic Kidney Disease Epidemiology Collaboration equation without the race variable has been recently proposed (CKD-EPIAS). This neither validated outside USA nor compared with European Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in cohorts.Standardized creatinine measured glomerular filtration rate (GFR) from EKFC cohorts (n = 13 856 including 6031 individuals external validation cohort), France 4429, 964 Black Europeans), Brazil 100) Africa 508)...
International consensus supports the development of standardized mGFR protocols to facilitate implementation more widespread and routine testing in clinical care research protocols. With support from EKFC, an international group experts performed extensive literature search develop recommendations for a approach determine mGFR. This paper evaluated evidence formulated that include all aspects iohexol plasma clearance measurement adults not on dialysis. These practical advice patient...
eGFR on the basis of creatinine (eGFRcre) associates differently with cardiovascular disease and mortality than cystatin C (eGFRcys). This may be related to risk factors affecting level along non-GFR pathways, which confound association between outcome. Nontraditional are usually not measured in epidemiologic studies cannot adjusted for reduce confounding. We examined whether inflammatory markers soluble TNF receptor type 2 (sTNFR2), C-reactive protein (CRP), fibrinogen associated GFR...
Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), link in the causal chain between diabetes and chronic kidney Whether obesity associated with hyperfiltration non-diabetic general population, remains unresolved due to lack of consensus regarding definition limited precision high-range GFR estimations creatinine and/or cystatin C. 1555 middle-aged participants without diabetes, or cardiovascular disease...
Background-The development of asthma seems to be influenced by the adoption a Western lifestyle.A study was undertaken assess importance indoor environmental factors in Nepal where lifestyle and home environment diVer from that West.Methods-The 121 schoolchildren with 126 controls aged 11-17 years studied.The homes all participants were investigated children their mothers interviewed using standardised questionnaire.Cases identified an ISAAC (International Study Asthma Allergy Childhood)...
<b><i>Background:</i></b> Estimated glomerular filtration rate (eGFR) based on either cystatin C or creatinine performs similarly in estimating measured GFR, but associate differently with cardiovascular disease (CVD) and mortality. This could be due to confounding by non-GFR-related traits associated levels. We investigated associations between eGFR two types of nontraditional risk factors for CVD death: <smlcap>L</smlcap>-arginine/dimethylarginine...
Hyperfiltration at the single-nephron level has been proposed as an early stage of kidney dysfunction different origins. Evidence supporting this hypothesis in humans is lacking, because there no method measuring GFR humans. However, increased whole-kidney same individual implies GFR, number nephrons does not increase with age. We hypothesized that would be associated albumin-to-creatinine ratio a cohort general population.We measured by iohexol clearance baseline 2007-2009 and follow-up...
The Cockcroft-Gault (CG) creatinine-based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead hazardous over- or underdosing.In a cross-sectional analysis, CG was validated against measured GFR (mGFR) in 14 804 participants and compared with the Modification-of-Diet-in-Renal-Diseases (MDRD), Chronic-Kidney-Disease-Epidemiology (CKD-EPI), Lund-Malmö-Revised (LMR) European-Kidney-Function-Consortium (EKFC) equations....