A5091364019- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Multiple Myeloma Research and Treatments
- Parathyroid Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Renal Diseases and Glomerulopathies
- Kidney Stones and Urolithiasis Treatments
- Acute Kidney Injury Research
- Vitamin D Research Studies
- Pediatric Urology and Nephrology Studies
- Bipolar Disorder and Treatment
- Bone health and osteoporosis research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Lymphocytic Leukemia Research
- Cardiac, Anesthesia and Surgical Outcomes
- Birth, Development, and Health
- Fatty Acid Research and Health
- Pharmacological Effects and Toxicity Studies
- Atrial Fibrillation Management and Outcomes
- Eicosanoids and Hypertension Pharmacology
- Genetic Syndromes and Imprinting
- Renal Transplantation Outcomes and Treatments
- Long-Term Effects of COVID-19
- Neonatal Health and Biochemistry
- COVID-19 Clinical Research Studies
National University Hospital of Iceland
2016-2025
Reykjavík University
2005-2025
University of Iceland
2002-2024
Brigham and Women's Hospital
2016
Pediatric Nephrology of Alabama
2004-2015
Duke Medical Center
1995-2003
Duke University
1996-2001
Health Sciences Centre
2001
Sunnybrook Health Science Centre
2001
Duke University Hospital
1996-2000
Lipoprotein(a) [Lp(a)] is a causal risk factor for cardiovascular diseases that has no established therapy. The attribute of Lp(a) affects not established. Low levels have been associated with type 2 diabetes (T2D). This study investigated whether conferred by molar concentration or apolipoprotein(a) [apo(a)] size, and the relationship between T2D causal. was case-control 143,087 Icelanders genetic information, including 17,715 coronary artery disease (CAD) 8,734 T2D. used measured...
Abstract Serum free light chain (FLC) concentration is greatly affected by kidney function. Using a large prospective population-based cohort, we aimed to establish reference interval for FLCs in persons with chronic disease (CKD). A total of 75422 participants the iStopMM study were screened serum FLC, protein electrophoresis and immunofixation. Estimated glomerular filtration rate (eGFR) was calculated from creatinine. Central 99% intervals determined, 95% confidence calculated. Included...
The European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with ESKD. This paper is a summary of the ERA Annual Report 2020, also including comparisons among primary renal disease (PRD) groups.Data were collected from 52 national and regional registries 34 countries bordering Mediterranean Sea: 35 18 providing individual level 17 aggregated data. Using this data, KRT incidence prevalence, transplantation rates, expected remaining lifetimes...
We investigated if the circulating levels of phosphaturic factor FGF23 are elevated in subjects with XLH. Although we failed to find a statistically significant increase, were significantly correlated degree hypophosphatemia In contrast, markedly increased ESRD and inversely hyperphosphatemia.Inactivating mutations PHEX cause renal phosphate wasting X-linked hypophosphatemic rickets (XLH) because accumulation hormone called phosphatonin. The recent discovery that is autosomal dominant raises...
Patients with pseudohypoparathyroidism type Ib (PHP-Ib) have hypocalcemia and hyperphosphatemia due to renal parathyroid hormone (PTH) resistance, but lack physical features of Albright hereditary osteodystrophy. PHP-Ib is thus distinct from PHP-Ia, which caused by mutations in the GNAS exons encoding G protein α subunit. However, an imprinted autosomal dominant form (AD-PHP-Ib) has been mapped a region chromosome 20q13.3 containing GNAS. Furthermore, loss methylation at differentially...
Chronic kidney disease (CKD) is a worldwide public health problem that associated with substantial morbidity and mortality. To search for sequence variants associate CKD, we conducted genome-wide association study (GWAS) included total of 3,203 Icelandic cases 38,782 controls. We observed an between CKD variant 80% population frequency, rs4293393-T, positioned next to the UMOD gene (GeneID: 7369) on chromosome 16p12 (OR = 1.25, P 4.1×10−10). This encodes uromodulin (Tamm-Horsfall protein),...
Current guidelines recommend reporting eGFR using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations unless other are more accurate, and combination of creatinine cystatin C (eGFRcr-cys) as accurate than either eGFRcr or eGFRcys alone. However, preferred filtration markers in elderly individuals debated. In 805 adults enrolled community-based Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, we measured GFR (mGFR) plasma clearance iohexol, standardized C,...
Abstract Kidney stone disease is a complex disorder with strong genetic component. We conducted genome-wide association study of 28.3 million sequence variants detected through whole-genome sequencing 2,636 Icelanders that were imputed into 5,419 kidney cases, including 2,172 cases history recurrent stones, and 279,870 controls. identify associating stones at ALPL (rs1256328[T], odds ratio (OR)=1.21, P =5.8 × 10 −10 ) suggestive CASR (rs7627468[A], OR=1.16, =2.0 −8 ). Focusing our analysis...
Acute kidney injury (AKI) is a serious complication after major surgical procedures. We examined the incidence, risk factors, and mortality of patients who sustained AKI abdominal surgery in large population-based cohort.All underwent open laparoscopic (excluding genitourinary vascular procedures), between 2007 2014 at University Hospital Reykjavik were identified their perioperative serum creatinine (SCr) measurements used to identify employing Kidney Disease: Improving Global Outcome...
Kidney stone disease has been associated with reduced kidney function and chronic (CKD). The objective of the study was to examine function, body mass index (BMI) prevalence cardiovascular disease, hypertension diabetes in recurrent formers. A cross-sectional, case-control comparing measures BMI comorbid conditions conducted 195 patients aged 18 70 years clinical events 390 age- gender-matched controls. Wilcoxon-Mann-Whitney, chi-square tests analysis covariance were used compare serum...
Abstract Monoclonal gammopathy of undetermined significance (MGUS) precedes multiple myeloma (MM). Population-based screening for MGUS could identify candidates early treatment in MM. Here we describe the Iceland Screens, Treats, or Prevents Multiple Myeloma study (iStopMM), first population-based including a randomized trial follow-up strategies. Icelandic residents born before 1976 were offered participation. Blood samples are collected alongside blood sampling healthcare system....
ABSTRACT Background The European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with end-stage disease (ESKD). This paper is a summary of the ERA Annual Report 2021, including comparison across treatment modalities. Methods Data was collected from 54 national and regional registries 36 countries, which 35 18 countries contributed individual patient 19 aggregated data. Using this data, incidence prevalence KRT, transplantation rates, survival...
This paper compares the most recent data on incidence and prevalence of kidney replacement therapy (KRT), transplantation rates, mortality KRT from Europe to those United States (US), including comparisons treatment modalities (haemodialysis (HD), peritoneal dialysis (PD), (KTx)).
International consensus supports the development of standardized mGFR protocols to facilitate implementation more widespread and routine testing in clinical care research protocols. With support from EKFC, an international group experts performed extensive literature search develop recommendations for a approach determine mGFR. This paper evaluated evidence formulated that include all aspects iohexol plasma clearance measurement adults not on dialysis. These practical advice patient...
To examine the effect of n -3 polyunsaturated fatty acid (PUFA) treatment on incidence post-operative atrial fibrillation (POAF). A prospective, randomized, double-blinded, placebo-controlled trial was conducted in patients admitted for coronary artery bypass grafting and/or valvular repair surgery. The received either PUFA capsules, containing a daily dose 1240 mg eicosapentaenoic and 1000 docosahexaenoic acid, or olive oil capsules 5–7 days prior to surgery post-operatively until hospital...
Abstract Objective To characterise the symptoms of coronavirus disease 2019 (covid-19). Design Population based cohort study. Setting Iceland. Participants All individuals who tested positive for severe acute respiratory syndrome 2 (SARS-CoV-2) by reverse transcription polymerase chain reaction (RT-PCR) between 17 March and 30 April 2020. Cases were identified three testing strategies: targeted guided clinical suspicion, open invitation population screening on self referral, random...