Gudmundur L. Norddahl
A5048347827- Acute Myeloid Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- RNA Research and Splicing
- Osteoarthritis Treatment and Mechanisms
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Advanced Proteomics Techniques and Applications
- T-cell and B-cell Immunology
- COVID-19 epidemiological studies
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
- Genomics and Rare Diseases
- Cancer-related molecular mechanisms research
- Immunodeficiency and Autoimmune Disorders
- Congenital heart defects research
- Long-Term Effects of COVID-19
- Cancer Genomics and Diagnostics
- Genomic variations and chromosomal abnormalities
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune responses and vaccinations
deCODE Genetics (Iceland)
2016-2025
Directorate of Health
2020
University of Iceland
2020
National University Hospital of Iceland
2020
BC Cancer Agency
2014-2017
Lund University
2007-2017
Amgen (Germany)
2016
Terry Fox Research Institute
2016
BackgroundDuring the current worldwide pandemic, coronavirus disease 2019 (Covid-19) was first diagnosed in Iceland at end of February. However, data are limited on how SARS-CoV-2, virus that causes Covid-19, enters and spreads a population.MethodsWe targeted testing to persons living who were high risk for infection (mainly those symptomatic, had recently traveled high-risk countries, or contact with infected persons). We also carried out population screening using two strategies: issuing...
Little is known about the nature and durability of humoral immune response to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).We measured antibodies in serum samples from 30,576 persons Iceland, using six assays (including two pan-immunoglobulin [pan-Ig] assays), we determined that appropriate measure seropositivity was a positive result both pan-Ig assays. We tested 2102 collected 1237 up 4 months after diagnosis by quantitative polymerase-chain-reaction (qPCR)...
Lipoprotein(a) [Lp(a)] is a causal risk factor for cardiovascular diseases that has no established therapy. The attribute of Lp(a) affects not established. Low levels have been associated with type 2 diabetes (T2D). This study investigated whether conferred by molar concentration or apolipoprotein(a) [apo(a)] size, and the relationship between T2D causal. was case-control 143,087 Icelanders genetic information, including 17,715 coronary artery disease (CAD) 8,734 T2D. used measured...
High-throughput proteomics platforms measuring thousands of proteins in plasma combined with genomic and phenotypic information have the power to bridge gap between genome diseases. Here we performed association studies Olink Explore 3072 data generated by UK Biobank Pharma Proteomics Project
Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. We performed a genome-wide association study of NAFL, cirrhosis hepatocellular carcinoma, integrated the findings with expression proteomic data. For we utilized 9,491 clinical cases proton density fat fraction extracted from 36,116 magnetic resonance images. identified 18 sequence variants associated NAFL 4 cirrhosis, found rare, protective, predicted loss-of-function in MTARC1 GPAM, underscoring them as potential...
Several sequence variants are known to have effects on serum levels of non–high-density lipoprotein (HDL) cholesterol that alter the risk coronary artery disease.
Mutations in genes encoding subunits of the phagocyte NADPH oxidase complex are recognized to cause chronic granulomatous disease (CGD), a severe primary immunodeficiency. Here we describe how deficiency CYBC1, previously uncharacterized protein humans (C17orf62), leads reduced expression oxidase's main subunit (gp91phox) and results CGD. Analyzing two brothers diagnosed with CGD identify homozygous loss-of-function mutation, p.Tyr2Ter, CYBC1. Imputation p.Tyr2Ter into 155K chip-genotyped...
Abstract Bone area is one measure of bone size that easily derived from dual-energy X-ray absorptiometry (DXA) scans. In a GWA study DXA the hip and lumbar spine (N ≥ 28,954), we find thirteen independent association signals at twelve loci replicate in samples European East Asian descent ( N = 13,608 – 21,277). Eight associate with osteoarthritis, including rs143384 GDF5 missense variant COL11A1 (rs3753841). The strongest rs11614913[T] microRNA MIR196A2 gene associates P 2.3 × 10 −42 , β...
Abstract BACKGROUND Limited data exist on how SARS-CoV-2 enters and spreads in the general population. METHODS We used two strategies for testing: targeted testing of high-risk individuals (n=4,551) a population screening (n=5,502). sequenced from 340 individuals. RESULTS On March 22 2020, 528 had tested positive (11.6%) 50 (0.9%); approximately 0.2% Icelandic Large fractions positives travelled outside Iceland (38.4% 34.0%). Fewer under 10 years old were than those older: 2.8% vs. 12.3%...
Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) ~1 million controls from Northwestern Europe. searched outside the HLA-locus through effect on coding, mRNA expression in several tissues levels plasma proteins (SomaScan) did network analysis (Qiagen). Results found 25 sequence variants overall, 33 2 RA, altogether...
Abstract Most sequence variants identified hitherto in genome-wide association studies (GWAS) of atrial fibrillation are common, non-coding associated with risk through unknown mechanisms. We performed a meta-analysis GWAS among 29,502 cases and 767,760 controls from Iceland the UK Biobank follow-up samples Norway US, focusing on low-frequency coding splice aiming to identify causal genes. observe associations one missense (OR = 1.20) splice-donor variant 1.50) RPL3L , first ribosomal gene...