Steinunn Guðmundsdóttir
A5081560144- Nanocomposite Films for Food Packaging
- Long-Term Effects of COVID-19
- Studies on Chitinases and Chitosanases
- Immunodeficiency and Autoimmune Disorders
- Asthma and respiratory diseases
- RNA modifications and cancer
- Gastrointestinal disorders and treatments
- Lipoproteins and Cardiovascular Health
- Olfactory and Sensory Function Studies
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Diabetes and associated disorders
- Helicobacter pylori-related gastroenterology studies
- Blood groups and transfusion
- Tuberculosis Research and Epidemiology
- Urinary and Genital Oncology Studies
- IL-33, ST2, and ILC Pathways
- Cardiovascular Disease and Adiposity
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- Invertebrate Immune Response Mechanisms
- Immune responses and vaccinations
- Genetics and Neurodevelopmental Disorders
- RNA Research and Splicing
- Legionella and Acanthamoeba research
deCODE Genetics (Iceland)
2017-2024
Directorate of Health
2020
University of Iceland
2015-2020
National University Hospital of Iceland
2020
Little is known about the nature and durability of humoral immune response to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).We measured antibodies in serum samples from 30,576 persons Iceland, using six assays (including two pan-immunoglobulin [pan-Ig] assays), we determined that appropriate measure seropositivity was a positive result both pan-Ig assays. We tested 2102 collected 1237 up 4 months after diagnosis by quantitative polymerase-chain-reaction (qPCR)...
Mutations in genes encoding subunits of the phagocyte NADPH oxidase complex are recognized to cause chronic granulomatous disease (CGD), a severe primary immunodeficiency. Here we describe how deficiency CYBC1, previously uncharacterized protein humans (C17orf62), leads reduced expression oxidase's main subunit (gp91phox) and results CGD. Analyzing two brothers diagnosed with CGD identify homozygous loss-of-function mutation, p.Tyr2Ter, CYBC1. Imputation p.Tyr2Ter into 155K chip-genotyped...
Abstract Diverticular disease is characterized by pouches (that is, diverticulae) due to weakness in the bowel wall, which can become infected and inflamed causing diverticulitis, with potentially severe complications. Here, we test 32.4 million sequence variants identified through whole-genome sequencing (WGS) of 15,220 Icelanders for association diverticular (5,426 cases) its more form diverticulitis (2,764 cases). Subsequently, 16 are followed up a sample from Denmark (5,970 cases, 3,020...
Abstract Chitosan, the deacetylated derivative of chitin, is used as biomaterial in diverse settings. It also found on pathogens and can be proinflammatory. Shorter derivatives chitosan generated chemically or enzymatically, oligosaccharides (ChOS). There variation chemical composition ChOS, including size distribution, but general, they have been described inert anti‐inflammatory. Active human chitinases cleave chitin chitosan, while inactive bind both do not cleave. Both active important...
Background: Loss-of-function mutations in the LDL (low-density lipoprotein) receptor gene ( LDLR ) cause elevated levels of cholesterol and premature cardiovascular disease. To date, a gain-of-function mutation with large effect on has not been described. Here, we searched for sequence variants that have levels. Methods: We analyzed whole-genome sequencing data from 43 202 Icelanders. Single-nucleotide polymorphisms structural including deletions, insertions, duplications were genotyped...
Persistent symptoms are common after SARS-CoV-2 infection but correlation with objective measures is unclear.We invited all 3098 adults who tested positive in Iceland before October 2020 to the deCODE Health Study. We compared multiple and physical between 1706 Icelanders confirmed prior (cases) participated, 619 contemporary 13,779 historical controls. Cases participated study 5-18 months infection.Here we report that 41 of 88 associated infection, most significantly disturbed smell taste,...