A5083650229- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Chronic Lymphocytic Leukemia Research
- Multiple Sclerosis Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Lymphoma Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Celiac Disease Research and Management
- Inflammatory Myopathies and Dermatomyositis
- Genetic Associations and Epidemiology
- Viral Infections and Immunology Research
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Microscopic Colitis
- Hepatitis C virus research
- HER2/EGFR in Cancer Research
- Peripheral Neuropathies and Disorders
- Mast cells and histamine
- Acute Myocardial Infarction Research
- Dermatologic Treatments and Research
- Evolution and Genetic Dynamics
- Pediatric health and respiratory diseases
- Bioinformatics and Genomic Networks
Karolinska Institutet
2016-2025
Karolinska University Hospital
2022
Hebrew SeniorLife
2018
Harvard University
2018
Vanderbilt University
2018
American College of Rheumatology
2018
Specifica (United States)
2016
Data on familial recurrence rates of complex diseases such as multiple sclerosis give important hints to aetiological factors the importance genes and environment. By linking national registries, we sought avoid common limitations clinic-based studies low numbers, poor representation population selection bias. Through Swedish Multiple Sclerosis Registry a nationwide hospital registry, total 28 396 patients with were identified. We used Multi-Generation identify first second degree relatives...
The Multiple Sclerosis Severity Score (MSSS) is obtained by normalising the Expanded Disability Status Scale (EDSS) score for disease duration and has been a valuable tool in cross-sectional studies.To assess whether use of age rather than inherently ambiguous was feasible approach.We pooled disability data from three population-based cohorts developed an Age Related (ARMSS) ranking EDSS scores based on patient's at time assessment. We established power to detect difference between groups...
Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) ~1 million controls from Northwestern Europe. searched outside the HLA-locus through effect on coding, mRNA expression in several tissues levels plasma proteins (SomaScan) did network analysis (Qiagen). Results found 25 sequence variants overall, 33 2 RA, altogether...
To investigate how individual rheumatoid arthritis (RA) autoantibodies associate with signs and symptoms at the time of RA diagnosis.
Collagenous colitis (CC) is a major cause of chronic non-bloody diarrhoea, particularly in the elderly female population. The aetiology CC unknown, and still poor understanding its pathogenesis. This possibly involves dysregulated inflammation immune-mediated reactions genetically predisposed individuals, but contribution genetic factors to underinvestigated. We systematically tested immune-related genes known impact risk several autoimmune diseases for their potential CC-predisposing...
Multiple sclerosis (MS) is a complex disease of the central nervous system unknown etiology. The human leukocyte antigen (HLA) locus on chromosome 6 confers considerable part susceptibility to MS, and most important factor class II allele HLA-DRB1*15:01. In addition, we others have previously established protective effect HLA-A*02. Here, genotyped 1,784 patients 1,660 healthy controls from Scandinavia for HLA-A, HLA-B, HLA-C HLA-DRB1 genes investigated their effects MS risk by logistic...
OBJECTIVE: In rheumatoid arthritis (RA) several recent efforts have sought to discover means of predicting which patients would benefit from treatment. However, results been discrepant with few successful replications. Our objective was build a biobank DNA, RNA and protein measurements test the claim that current state-of-the-art precision medicine will RA patients. METHODS: We collected 451 blood samples 61 healthy individuals 185 initiating treatment, before treatment initiation at 3 month...
Background: An increasing women-to-men ratio in later birth cohorts of patients with multiple sclerosis (MS) has been observed several populations and hypothesised to be due one or environmental factors importance for disease aetiology. However, a study based on data from the Swedish MS registry (SMSreg) this was recently reported rather stable during 20 th century. Objective: The purpose reinvestigate Sweden all available sources, including deceased patients. Method: We combined SMSreg...
Background: Several reports indicate changes to prevalence, incidence, female-to-male ratio in multiple sclerosis. Diagnostic criteria, course definitions and clinical management of the disease have also undergone change during recent decades. Objective: To investigate temporal trends diagnosis primary progressive sclerosis (PPMS) Sweden. Methods: Through Swedish MS registry we investigated proportion PPMS birth, age period cohorts using Poisson regression. Results: A total 16,915 patients...
Rheumatoid arthritis (RA) is the most common immune-mediated arthritis. Anti-citrullinated peptide antibodies (ACPA) are highly specific to RA and assayed with commercial CCP2 assay. Genetic drivers of within MHC different for CCP2-positive -negative subsets RA, particularly at HLA-DRB1. However, aspartic acid amino position 9 in HLA-B (Bpos-9) increases risk both subsets. Here we explore how individual serologies associated drive associations MHC. To define differences ACPA serologies,...
Antifibrillar collagen type II (anti-CII) antibody-positive patients with rheumatoid arthritis (RA) have early but not late signs of increased inflammation and joint erosions. We wanted to replicate this in a large RA cohort, relate human leukocyte antigen (HLA)-DRB1* alleles.Anti-CII anti-cyclic citrullinated peptide (CCP)2 were measured at baseline 773 from the Swedish Epidemiological Investigation Rheumatoid Arthritis (EIRA) study clinical follow-up data Rheumatology Quality Register...
To investigate potential associations between dietary intake of polyunsaturated fatty acids (FAs) and pain patterns in early rheumatoid arthritis (RA) patients after 3 months methotrexate (MTX) treatment.We included 591 RA with MTX monotherapy from a population-based prospective case-control study, the Epidemiological Investigation Rheumatoid Arthritis. Dietary data on FAs (food frequency questionnaires) were linked unacceptable (visual analog scale [VAS] >40 mm), noninflammatory/refractory...
The link and interplay between different airway exposures rheumatoid arthritis (RA) risk are unclear. This study was undertaken to determine whether respiratory disease is associated with development of RA, specifically examine this relationship by RA serostatus smoking exposure.Using data from the Epidemiological Investigation Rheumatoid Arthritis study, analysis included 1,631 incident cases 3,283 matched controls recruited 2006 2016. Linking these individuals National Patient Register...
To investigate the relationship between anti-citrullinated protein antibodies (ACPAs), specific ACPA subspecificities, rheumatoid factor (RF) isotypes, and incident cardiovascular (CV) events in patients with arthritis (RA).Serum samples from Swedish new-onset RA (diagnosed within 1 year of symptom onset 1996 2009) were centrally typed for anti-cyclic citrullinated peptide 2 (anti-CCP2) antibodies, 20 RF isotypes. Patients followed up longitudinally nationwide registers to monitor occurrence...
Background Methotrexate (MTX) is the first line treatment for rheumatoid arthritis (RA), but failure of satisfying response occurs in a significant proportion patients. Here we present longitudinal multi-omics study aimed at detecting molecular and cellular processes peripheral blood associated with successful methotrexate arthritis. Methods Eighty newly diagnosed patients RA underwent clinical assessment donated before initiation MTX, 3 months into treatment. Flow cytometry was used to...
Precision medicine in rheumatoid arthritis (RA) requires a good understanding of treatment outcomes and often collaborative efforts that call for data harmonisation. We aimed to describe how harmonisation across study cohorts can be achieved investigate the observed proportions reaching remission vary criteria, types, disease-modifying antirheumatic drugs (DMARDs) countries, they relate other outcomes. used from eight existing large-scale, clinical RA registers pragmatic trial Sweden,...
Objective The antibody response against Porphyromonas gingivalis ( Pg ) is elevated in rheumatoid arthritis (RA), especially patients with anti-citrullinated protein antibodies (ACPA). Here, we investigated whether the virulence factor arginine gingipain (Rgp) are associated RA-risk phase and development of arthritis. Methods At-risk individuals were included a prospective study (Risk-RA) based on positive anti-cyclic citrullinated peptide 2 (CCP2) test, having musculoskeletal complaints but...
Rheumatoid arthritis (RA) associated anti-citrullinated protein antibodies (ACPA) target various antigens by binding short citrulline-amino acid motifs, resulting in heterogeneous ACPA-profiles among patients. Here we analyzed ACPA-patterns recognized citrulline-motifs relation to the RA risk factors HLA-DRB1 shared epitope (SE) alleles and history of smoking. factor (RF) anti-cyclic citrullinated peptide (CCP2) isotypes, 15 anti-Cit- four anti-Carb/Acet-peptide-IgG, were centrally measured...
Objective Most studies of rheumatoid arthritis (RA) and sleep have focused on established RA. We here investigate quality duration in patients with newly diagnosed RA during 1–12 years after diagnosis. Methods Data were collected diagnosis from 1998–2018 the Swedish study Epidemiological Investigation Six domains (sleep problems, non-restorative sleep, insomnia, insufficient perceived as poor considered a health problem); global score time spent bed estimated. Using logistic regression, ORs...
Abstract Background Methotrexate (MTX) is the mainstay initial treatment of rheumatoid arthritis (RA), but individual response varies and remains difficult to predict. The role genetics unclear, studies suggest its importance. Methods Incident RA patients starting MTX‐monotherapy were identified through a large‐scale Swedish register linkage. Demographic, clinical, medical, drug history features combined with fully imputed genotype data used train evaluate multiple learning models predict...