A5042508118- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced MRI Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Cerebral Venous Sinus Thrombosis
- Neurotransmitter Receptor Influence on Behavior
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Optical Imaging and Spectroscopy Techniques
- Advanced Neuroimaging Techniques and Applications
- Neurosurgical Procedures and Complications
- Fault Detection and Control Systems
- Pituitary Gland Disorders and Treatments
- Ultrasound and Hyperthermia Applications
- Obsessive-Compulsive Spectrum Disorders
- Neuroscience of respiration and sleep
- Radiopharmaceutical Chemistry and Applications
- Seismic Imaging and Inversion Techniques
- Systemic Lupus Erythematosus Research
- Neuroscience and Neuropharmacology Research
- Viral Infections and Immunology Research
- Obstructive Sleep Apnea Research
- Time Series Analysis and Forecasting
- Acute Ischemic Stroke Management
Glostrup Hospital
2023
Rigshospitalet
2019-2023
Copenhagen University Hospital
2019-2023
Technical University of Denmark
2020-2023
Ørsted (Denmark)
2021
Chemogenetic studies with the ligand clozapine N-oxide (CNO) are predicated upon assumption that CNO is devoid of actions at natural neuroreceptors. However, recent evidence shows may be converted back to (CLZ) in vivo, which could yield plasma concentrations sufficient occupy inter alia dopamine D2/3 and serotonin 5HT2A receptors living brain. To test this phenomenon, we measured striatal receptor occupancy [18F]fallypride PET ex vivo using [18F]MH.MZ. We found a dose-dependent effect on...
Precision medicine in rheumatoid arthritis (RA) requires a good understanding of treatment outcomes and often collaborative efforts that call for data harmonisation. We aimed to describe how harmonisation across study cohorts can be achieved investigate the observed proportions reaching remission vary criteria, types, disease-modifying antirheumatic drugs (DMARDs) countries, they relate other outcomes. used from eight existing large-scale, clinical RA registers pragmatic trial Sweden,...
Repetitive transient intracranial pressure waveform elevations up to 50 mmHg (ICP B-waves) are often used define pathological conditions and determine indications for ICP-reducing treatment. We recently showed that nocturnal ICP present in patients without structural brain lesions or hydrocephalus whom they associated with sleep apnea. However, whether this signifies a general association between macropatterns apnea remains unknown.
Slow vasogenic waves in arterial blood pressure (ABP), intracranial (ICP) and cerebral flow velocity (FV) carry information on multiple brain homeostatic control mechanisms. This work presents an approach to evaluate causal relation between oscillatory modes of these signals as alternative time or frequency domain Granger analysis.Forty-five patients with simultaneous recordings ICP, ABP FV during CSF infusion studies were examined retrospectively. Each series was decomposed into ten...
Abstract Intracranial pressure (ICP) B‐waves are defined as short, repeating elevations of ICP up to 50 mmHg with a frequency 0.5–2 waves/min. The presence in overnight recordings is regarded pathological phenomenon. However, the physiology still not fully understood and studies transcranial Doppler, surrogate marker for ICP, have suggested that could be normal physiological We present four patients without known structural neurological disease other than coincidentally found unruptured...
Intracranial pressure (ICP) monitoring is a core component of neurosurgical diagnostics. With the introduction telemetric devices in last years, ICP has become feasible broader clinical setting including during full mobilization and at home, where greater diversity waveforms are present. The need for identification these variations, so-called macro-patterns lasting seconds to minutes-emerges as potential tool better understanding physiological underpinnings patient symptoms.We introduce new...
Abstract Background : Intracranial pressure (ICP) monitoring is a core component of neurosurgical diagnostics. With the introduction telemetric devices in last years, ICP has become feasible broader clinical setting including during full mobilization and at home, where greater diversity waveforms are present. The need for identification these variations, so-called macro-patterns lasting seconds to minutes - emerges as potential tool better understanding physiological underpinnings patient...
Abstract Background Repetitive transient intracranial pressure waveform elevations up to 50 mmHg (ICP B-waves) are often used define pathological conditions and determine pressure-reducing treatment indications. We recently showed that nocturnal ICP present in patients without structural brain lesions or hydrocephalus whom they associated with sleep apnea. However, whether this signifies a general association between patterns apnea is still unknown. Methods included 34 hydrocephalus,...