A5083533438- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience of respiration and sleep
- Cerebrospinal fluid and hydrocephalus
- Neuroinflammation and Neurodegeneration Mechanisms
- Sleep and related disorders
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Obsessive-Compulsive Spectrum Disorders
- Circadian rhythm and melatonin
- EEG and Brain-Computer Interfaces
- RNA regulation and disease
- Photoreceptor and optogenetics research
- Neonatal and fetal brain pathology
- Autism Spectrum Disorder Research
- CRISPR and Genetic Engineering
- Biochemical Analysis and Sensing Techniques
- Psychedelics and Drug Studies
- Chemical synthesis and alkaloids
- Neural dynamics and brain function
- Neurological disorders and treatments
- Nerve injury and regeneration
- Glaucoma and retinal disorders
- Mitochondrial Function and Pathology
University of Copenhagen
2013-2025
Lundbeck (Denmark)
2013-2017
University of California, San Francisco
2016-2017
Center for Theoretical Biological Physics
2016
Rigshospitalet
2010
Abstract Information transfer within neuronal circuits depends on the balance and recurrent activity of excitatory inhibitory neurotransmission. Chloride (Cl − ) is major central nervous system (CNS) anion mediating Astrocytes are key homoeostatic glial cells populating CNS, although role these in regulating excitatory-inhibitory remains unexplored. Here we show that astrocytes act as a dynamic Cl reservoir homoeostasis CNS. We found intracellular chloride concentration ([Cl ] i high stable...
Abstract Obesity affects millions of people worldwide and is associated with an increased risk cognitive decline. The glymphatic system a brain-wide metabolic waste clearance system, dysfunction which linked to dementia. We herein examined transport in mice long-term obesity induced by high-fat diet for 10 months. obese developed hypertension elevated heart rate, neuroinflammation gliosis, but not apparent systemic inflammation. Surprisingly, inflow was globally unaffected the except...
Both medial prefrontal cortex (mPFC) and serotonin play key roles in anxiety; however, specific mechanisms through which might act on the mPFC to modulate anxiety-related behavior remain unknown. Here, we use a combination of optogenetics synaptic physiology show that acts presynaptically via 5-HT1B receptors selectively suppress inputs from contralateral ventral hippocampus (vHPC), while sparing those mediodorsal thalamus. To elucidate how these actions could potentially regulate circuit...
Abstract Glymphatic transport is vital for the physiological homeostasis of retina and optic nerve. Pathological alterations ocular glymphatic fluid enlarged perivascular spaces have been described in glaucomatous mice. It remains to be established how diabetic retinopathy, which impairs vision about 50% diabetes patients, impacts transport. Here, we examined chronic hyperglycemic mice as well healthy experiencing a daily transient increase blood glucose. Mice suffering from severe two four...
Purpose of review Gamma oscillations (30–80 Hz) play a crucial role in sensory processing and cognitive functions, with disruptions these rhythms linked to neurological disorders such as schizophrenia Alzheimer's disease. This highlights the emerging astrocytes regulating gamma oscillations, emphasizing their contribution inhibitory tone extracellular ion homeostasis. Recent findings studies suggest that facilitate synchrony, while dysfunction astrocytic activity – impaired Ca 2+ signaling...
Summary We normally regard sleep and wake as two distinct opposing brain states, where requires silence of wake-promoting structures such the locus coeruleus (LC)-norepinephrine (NE) system. set out to investigate how cortical NE dynamics NE-related astrocytic activity relates LC population during states. show that displays regular phasic bouts NREM leading a slow oscillatory pattern prefrontal levels which majority increases does not lead awakening. troughs link spindles continued decline...
Sleep is not homogenous but contains a highly diverse microstructural composition influenced by neuromodulators. Prior methods used to measure neuromodulator levels in vivo have been limited low time resolution or technical difficulties achieving recordings freely moving setting, which essential for natural sleep. In this protocol, we demonstrate the combination of electroencephalographic (EEG)/electromyographic (EMG) with fiber photometric measurements fluorescent biosensors neuromodulators...
A compromised γ-aminobutyric acid (GABA)ergic system is hypothesized to be part of the underlying pathophysiology schizophrenia. N-methyl-d-aspartate (NMDA) receptor hypofunction during neurodevelopment proposed disrupt maturation interneurons causing an impaired GABAergic transmission in adulthood. The present study examines prefrontal adult rats administered with NMDA channel blocker, phencyclidine (PCP), for 3 days second postnatal week. Whole-cell patch-clamp recordings from pyramidal...
Symptoms of schizophrenia have been linked to insults during neurodevelopment such as NMDA receptor (NMDAR) antagonist exposure. In animal models, this leads schizophrenia-like behavioral symptoms well molecular and functional changes within hippocampal prefrontal regions. The aim study was determine how administration the NMDAR phencyclidine (PCP) affects network activity hippocampus medial cortex (mPFC). We recorded field potentials in vivo after electrical brain stem stimulation observed...
Psilocybin (a classic serotonergic psychedelic drug) has received appraisal for use in psychedelic-assisted therapy of several psychiatric disorders. A less explored topic concerns the repeated low doses psychedelics, at a dose that is well below used and often referred to as microdosing. microdose users report increases mental health, yet such reports are highly biased vulnerable placebo effects. Here we establish validate psilocybin microdose-like regimen rats using psilocybin. Dosing...
Automatic sleep staging based on electroencephalography (EEG) and electromyography (EMG) signals is an important aspect of sleep-related research. Current methods suffer from two major drawbacks. First, there are limited information interactions between modalities in the existing methods. Second, current do not develop unified models that can handle different sources input. To address these issues, we propose a novel stage scoring model sDREAMER, which emphasizes cross-modality interaction...
Efficiently identifying sleep stages is crucial for unraveling the intricacies of in both preclinical and clinical research. The labor-intensive nature manual scoring, demanding substantial expertise, has prompted a surge interest automated alternatives. Sleep studies mice play significant role understanding patterns disorders underscore need robust scoring methodologies. In response, this study introduces LG-Sleep, novel subject-independent deep neural network architecture designed through...