Magnus I. Magnusson
A5042514226- Genetic Associations and Epidemiology
- Advanced Proteomics Techniques and Applications
- Genomics and Rare Diseases
- Biological Research and Disease Studies
- Colorectal Cancer Treatments and Studies
- vaccines and immunoinformatics approaches
- Knee injuries and reconstruction techniques
- BRCA gene mutations in cancer
- Osteoarthritis Treatment and Mechanisms
- Genetic factors in colorectal cancer
- Genomic variations and chromosomal abnormalities
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Iron Metabolism and Disorders
- T-cell and B-cell Immunology
- Genetics and Neurodevelopmental Disorders
- Bioinformatics and Genomic Networks
- Genetic Syndromes and Imprinting
- Hemoglobinopathies and Related Disorders
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Folate and B Vitamins Research
- Immunotherapy and Immune Responses
deCODE Genetics (Iceland)
2018-2024
University of Iceland
2023
High-throughput proteomics platforms measuring thousands of proteins in plasma combined with genomic and phenotypic information have the power to bridge gap between genome diseases. Here we performed association studies Olink Explore 3072 data generated by UK Biobank Pharma Proteomics Project
Objective Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers OA that could predict disease occurrence and/or joint replacement. Methods Using the SomaScan platform, we measured 4,792 proteins in plasma from 37,278 individuals, whom 12,178 individuals had 2,524 undergone We performed a case–control identification potential protein hip, knee, hand OA, prospective Results Among large panel assessed, cartilage...
Discovery of coding variants in genes that confer risk neurodevelopmental disorders is an important step towards understanding the pathophysiology these disorders. Whole-genome sequencing 31,463 Icelanders uncovers a frameshift variant (E712KfsTer10) microtubule-associated protein 1B (MAP1B) associates with ID/low IQ large pedigree (genome-wide corrected P = 0.022). Additional stop-gain MAP1B (E1032Ter and R1664Ter) validate association ID IQ. Carriers have 24% less white matter (WM) volume...
The TNM system is used to assess prognosis after colorectal cancer (CRC) diagnosis. Other prognostic factors reported include histopathological assessments of the tumour, tumour mutations and proteins in blood. As some these are strongly correlated, it important evaluate independent effects they may have on survival.Tumour samples from 2162 CRC patients were visually assessed for amount stroma, severity lymphocytic infiltrate at margins presence lymphoid follicles. Somatic 2134 individuals....
The authors have withdrawn this manuscript because paper was posted prematurely in advance of a UK Biobank Pharma Proteomics Project consortium effort. Therefore, the do not wish work to be cited as reference for project. If you any questions, please contact corresponding author