A5012245215- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- HIV, Drug Use, Sexual Risk
- Hepatitis C virus research
- T-cell and B-cell Immunology
- Pneumocystis jirovecii pneumonia detection and treatment
- Nutrition and Health in Aging
- Lymphoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Immunodeficiency and Autoimmune Disorders
- Cytomegalovirus and herpesvirus research
- Polyomavirus and related diseases
- HIV/AIDS oral health manifestations
- Obstructive Sleep Apnea Research
- Sleep and related disorders
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Blood groups and transfusion
- Frailty in Older Adults
- Immunotherapy and Immune Responses
- Viral Infections and Immunology Research
Johns Hopkins University
2016-2025
Johns Hopkins Medicine
1995-2025
Bloomberg (United States)
2008-2024
University of Arkansas for Medical Sciences
2024
Centers for Disease Control and Prevention
2020
University of Rochester Medical Center
2020
Northwestern University
1994-2019
University of California, San Diego
1997-2019
Pittsburg State University
2019
Turku Centre for Biotechnology
2019
The hypothesis that quiescent CD4 + T lymphocytes carrying proviral DNA provide a reservoir for human immunodeficiency virus–type 1 (HIV-1) in patients on highly active antiretroviral therapy (HAART) was examined. In study of 22 successfully treated with HAART up to 30 months, replication-competent virus routinely recovered from resting lymphocytes. frequency cells harboring latent HIV-1 low, 0.2 16.4 per 10 6 cells, and, cross-sectional analysis, did not decrease increasing time therapy....
To understand the high variability of asymptomatic interval between primary human immunodeficiency virus type 1 (HIV-1) infection and development AIDS, we studied evolution C2-V5 region HIV-1 env gene T-cell subsets in nine men with a moderate or slow rate disease progression. They were monitored from time seroconversion for period 6 to 12 years until advanced seven men. Based on analysis viral divergence founder strain, population diversity within sequential points, outgrowth viruses...
Error in Renumbering References Text and Reference List in: Antiretroviral Therapy the Prevalence Incidence of Diabetes Mellitus Multicenter AIDS Cohort Study
Context.—Time to development of acquired immunodeficiency syndrome (AIDS) and time death have been extended with the increased use combination therapy protease inhibitors. Cohort studies following up persons human virus (HIV) infection in periods characterized by different therapies offer opportunity estimate effectiveness at population level.Objective.—To assess self-reported, long-term potent antiretroviral a cohort 536 men whose duration HIV was known (seroconverters).Design.—Cohort...
In a small percentage of persons infected with human immunodeficiency virus type 1 (HIV-1), there is no progression disease and CD4+ T-cell counts remain stable for many years. Studies the histopathological, virologic, immunologic characteristics these may provide insight into pathogenic mechanisms that lead to HIV protective prevent overt disease.
Side-population (SP) cells within cancers and cell lines are rare populations known to enrich cancer stem-like cells. In this study, we characterized SP from the human breast line MCF7 as a model for Compared with non-SP cells, had higher colony-formation ability in vitro greater tumorigenicity vivo, suggesting that cDNA microarray analysis of indicated expression ATP-binding cassette transporters genes involved quiescence, which were confirmed by quantitative RT-PCR flow cytometry cycle...
ABSTRACT Early in infection, human immunodeficiency virus type 1 (HIV-1) generally uses the CCR5 chemokine receptor (along with CD4) for cellular entry. In many HIV-1-infected individuals, viral genotypic changes arise that allow to use CXCR4 (either addition or alone) as an entry coreceptor. This switch has been associated acceleration of both CD3 + T-cell decline and progression AIDS. While it is well known V3 loop gp120 largely determines coreceptor usage positively charged residues play...
To extend the understanding of host genetic determinants HIV-1 control, we performed a genome-wide association study in cohort 2,554 infected Caucasian subjects. The was powered to detect common variants explaining down 1.3% variability viral load at set point. We provide overwhelming confirmation three associations previously reported and show further independent effects both rare Major Histocompatibility Complex region (MHC). also examined polymorphisms previous candidate gene studies fail...
Background. Older healthy and HIV-infected adults exhibit physiological similarities. Frailty is a clinical syndrome associated with aging that identifies subset of older at high risk mortality other outcomes. We investigated whether HIV infection increases the prevalence frailty-related phenotype (FRP) approximates definition frailty.
To investigate the impact of HAART-induced HIV suppression on levels 24 serological biomarkers inflammation and immune activation.A prospective cohort study.Biomarkers were measured with multiplex assays in centralized laboratories using stored serum samples contributed by 1697 men during 8903 person-visits Multicenter AIDS Cohort Study (MACS) from 1984 to 2009. Using generalized gamma models, we compared biomarker values across three groups, adjusting for possible confounders:...
Weight gain following antiretroviral therapy (ART) initiation is common, potentially predisposing some persons with HIV (PWH) to cardio-metabolic disease. We assessed relationships between ART drug class and weight change among treatment-naïve PWH initiating in the North American AIDS Cohort Collaboration on Research Design (NA-ACCORD).Adult, NA-ACCORD integrase strand transfer inhibitor (INSTI), protease (PI) or non-nucleoside reverse-transcriptase (NNRTI)-based on/after 1 January 2007 were...
The natural history of human immunodeficiency virus type 1 (HIV-1) viremia and its association with clinical outcomes after seroconversion was characterized in a cohort homosexual men. HIV-1 RNA measured by reverse-transcription polymerase chain reaction (RT-PCR) stored longitudinal plasma samples from 269 seroconverters. Subjects were generally antiretroviral drug naive for the first 3 years seroconversion. decline CD4 lymphocyte counts strongly associated initial HIV measurements. Both...
It is unclear whether there are differences between men and women with human immunodeficiency virus type 1 (HIV-1) infection in the plasma level of viral RNA (the load). In men, initial load after seroconversion predicts likelihood progression to acquired syndrome (AIDS), but relation two has not been assessed women. Currently, guidelines for initiating antiretroviral therapy applied uniformly men.
UO1-AI-35041: To examine the impact of HIV infection and highly active antiretroviral therapy on systolic diastolic hypertension.Cohort study with semi-annual assessment outcome.We studied 5578 participants Multicenter AIDS Cohort Study blood pressure measurements obtained between 1984 2003. The primary outcomes were hypertension (SH; > 140 mmHg) (DH; 90 mmHg). Statistical analyses performed using multiple logistic regression robust variance estimation.Of 84 813 person-visits available for...
GB virus C (GBV-C), which is not known to be pathogenic in humans, replicates lymphocytes, inhibits the replication of human immunodeficiency (HIV) vitro, and has been associated with a decreased risk death among HIV-positive persons some, but all, studies. Previous studies did control for differences duration HIV or GBV-C infection.
To estimate insulin resistance and its relationship to antiretroviral therapy (ART) in a cohort of HIV-infected persons with comparison HIV-seronegative controls.Prospective 533 755 men the Multicenter AIDS Cohort Study evaluated at 6-month intervals between 1999 2003.Recent ART exposure was assessed by type treatment preceding 6 months [i.e., no ART, monotherapy, combination or highly active (HAART) without protease inhibitor (PI)]. Cumulative determined for three major classes individual...
Summary: Laboratory markers that predict HIV-1 disease progression include plasma viral burden, CD4+ T-cell count, and CD38 expression on CD8 T cells. To better understand whether the predictive value of these is dependent how long an individual has been infected, we analyzed data from Multicenter AIDS Cohort Study early (median = 2.8 years) late 8.7 in course infection. Overall, found HIV RNA levels were similarly compared with a relatively weaker CD4 cell count signal. Later infection,...
Context.—Plasma human immunodeficiency virus type 1 (HIV-1) viral load and CD4+ cell count are used to predict prognosis of persons infected with HIV. However, whether combining these markers improves prognostic accuracy they for injection drug users (IDUs) nonwhite HIV has not been extensively investigated.Objective.—To evaluate plasma as indicators the acquired syndrome (AIDS) infectious disease deaths.Design.—Cohort study initiated in 1988 1989 follow-up up 7.9...