A5034360127- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- Viral-associated cancers and disorders
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- Cervical Cancer and HPV Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Lymphoma Diagnosis and Treatment
- Hepatitis C virus research
- LGBTQ Health, Identity, and Policy
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Polyomavirus and related diseases
- Genital Health and Disease
- Sexuality, Behavior, and Technology
- Physics and Engineering Research Articles
- Head and Neck Cancer Studies
- Opioid Use Disorder Treatment
- Sex work and related issues
- COVID-19 Clinical Research Studies
- Colorectal and Anal Carcinomas
- Adolescent Sexual and Reproductive Health
- SARS-CoV-2 and COVID-19 Research
- Homelessness and Social Issues
Kaiser Permanente
2016-2025
University of California, San Francisco
2011-2025
University of Calgary
2024
Hackensack University Medical Center
2019-2023
GTx (United States)
2007-2023
Harvard Pilgrim Health Care
2023
Harvard University
2023
Einstein Medical Center Philadelphia
2021
Northern California Research
2020
Office of Science
2019
Combination antiretroviral therapy (ART) has significantly increased survival among HIV-positive adults in the United States (U.S.) and Canada, but gains life expectancy for this region have not been well characterized. We aim to estimate temporal changes on ART from 2000-2007 U.S. Canada.Participants were North American AIDS Cohort Collaboration Research Design (NA-ACCORD), aged ≥20 years ART. Mortality rates calculated using participants' person-time January 1, 2000 or initiation until...
The optimal time for the initiation of antiretroviral therapy asymptomatic patients with human immunodeficiency virus (HIV) infection is uncertain.
This paper describes characteristics of opioid use episodes for noncancer pain and defines thresholds de facto long-term therapy.CONSORT (CONsortium to Study Opioid Risks Trends) includes adult members 2 health plans serving over 1% the US population. beginning in years 1997 2005 were classified as acute, episodic, long-term/lower dose, or long-term/higher dose.On basis evaluation likelihood continuing, therapy was defined by lasting longer than 90 days with 10+ prescriptions 120+ supply...
Abstract Objective To report trends and characteristics of long‐term opioid use for non‐cancer pain. Methods CONSORT (CONsortium to Study Opioid Risks Trends) includes adult enrollees two health plans serving over 1 per cent the US population. Using automated data, we constructed episodes between 1997 2005. We estimated age–sex standardized rates beginning in each year (incident) on‐going (prevalent), change annualized (PCA) 9‐year period. Long‐term were defined as > 90 days with 120+...
Little is known in human immunodeficiency virus (HIV)-positive women about how the combination of plasma HIV RNA level and CD4+ T-cell count associated with natural history papillomavirus (HPV) infection or HPV reactivation--whether it occurs what frequency HIV-positive women.HIV-positive (n = 1848) -negative 514) were assessed at semiannual visits (total person-years 5661) for cervicovaginal polymerase chain reaction assays squamous intraepithelial lesions (SILs) by Pap smear. We studied...
Background.Anal cancer is one of the most common cancers affecting individuals infected with human immunodeficiency virus (HIV), although few have evaluated rates separately for men who sex (MSM), other men, and women.There are also conflicting data regarding calendar trends.Methods.In a study involving 13 cohorts from North America follow-up between 1996 2007, we compared anal incidence among 34 189 HIV-infected (55% MSM, 19% 26% women) 114 260 HIV-uninfected (90% men).Results.Among...
<h3>Importance</h3> Antiretroviral therapy (ART) has improved life expectancy for individuals with HIV infection, but recent data comparing span and comorbidity-free years by status are lacking. <h3>Objective</h3> To quantify the gap in among adults access to care. <h3>Design, Setting, Participants</h3> This matched cohort study used from insured without infection (aged ≥21 years) 1:10 at medical centers of Kaiser Permanente northern southern California mid-Atlantic states Washington DC,...
Background: It is unknown if a survival gap remains between HIV-infected and HIV-uninfected individuals with access to care. Methods: We conducted cohort study within Kaiser Permanente California during 1996–2011, using abridged life tables estimate the expected years of remaining (“life expectancy”) at age 20. Results: Among 24,768 257,600 individuals, there were 2229 4970 deaths, mortality rates 1827 326 per 100,000 person-years, respectively. In 1996–1997, expectancies 20 for 19.1 63.4...
Background: Reductions in AIDS-related morbidity and mortality following the advent of combination antiretroviral therapy have coincided with relative increases chronic non-AIDS end-organ diseases among HIV+ patients. Objective: To examine association latest CD4+ counts risk a cohort 1397 patients who initiate therapy. Methods: HIV RNA levels along fatal, non-fatal, AIDS (liver, cardiovascular, renal, cancer) were assessed over median follow-up 5 years. Cox proportional regression models...
Background: Venous thromboembolism (VTE), ischemic stroke, and myocardial infarction in transgender persons may be related to hormone use. Objective: To examine the incidence of these events a cohort persons. Design: Electronic medical record–based study members integrated health care systems who had an index date (first evidence status) from 2006 through 2014. Ten male 10 female cisgender enrollees were matched each participant by year birth, race/ethnicity, site, enrollment. Setting:...
BACKGROUND: Understanding the magnitude of mental health problems, particularly life-threatening ones, experienced by transgender and/or gender nonconforming (TGNC) youth can lead to improved management these conditions. METHODS: Electronic medical records were used identify a cohort 588 transfeminine and 745 transmasculine children (3–9 years old) adolescents (10–17 enrolled in integrated care systems California Georgia. Ten male 10 female referent cisgender enrollees matched each TGNC...
Objectives. We describe age and gender trends in long-term use of prescribed opioids for chronic noncancer pain 2 large health plans. Methods. Age- gender-standardized incident (beginning each year) prevalent (ongoing) opioid episodes were estimated with automated care data from 1997 to 2005. Profiles 2005 by also compared. Results. From 2005, age–gender groups exhibited a total percentage increase ranging 16% 87% 61% 135% use. Women had higher than did men. Older women the highest...
Background: Cancer is increasingly common among persons with HIV. Objective: To examine calendar trends in cumulative cancer incidence and hazard rate by HIV status. Design: Cohort study. Setting: North American AIDS Collaboration on Research Design during 1996 to 2009. Participants: 86 620 196 987 uninfected adults. Measurements: type–specific age 75 years rates, each Results: Cumulative incidences of for without HIV, respectively, were as follows: Kaposi sarcoma, 4.4% 0.01%; non-Hodgkin...
Objective: To evaluate the risk of cancers with and without a known infectious cause in HIV-infected persons. Design: Retrospective cohort study. Methods: Adult matched HIV-uninfected members Kaiser Permanente followed between 1996 2007 for incident AIDS-defining (ADCs), infection-related non-AIDS-defining (NADCs; anal squamous cell, vagina/vulva, Hodgkin's lymphoma, penis, liver, human papillomavirus-related oral cavity/pharynx, stomach) infection-unrelated NADC (all other NADCs). Results:...
The proportion of overweight and obese adults in the United States Canada has increased over past decade, but temporal trends body mass index (BMI) weight gain on antiretroviral therapy (ART) among HIV-infected have not been well characterized. We conducted a cohort study comparing North America AIDS Cohort Collaboration Research Design (NA-ACCORD) to National Health Nutrition Examination Survey (NHANES) controls matched by sex, race, age period 1998 2010. Multivariable linear regression...
Abstract Background: Few studies have compared cancer risk between HIV-infected individuals and a demographically similar HIV-uninfected internal comparison group, adjusting for factors. Methods: We followed 20,775 215,158 enrolled in Kaiser Permanente (KP) California incident from 1996 to 2008. Rate ratios (RR) were obtained Poisson models comparing (overall stratified by recent CD4 count HIV RNA) with individuals, adjusted age, sex, race/ethnicity, calendar period, KP region, smoking,...
Placebo-controlled and open-label studies have demonstrated the safety efficacy of daily oral preexposure prophylaxis (PrEP) in preventing HIV infection, but data are limited on real-world PrEP use.We conducted a cohort study from July 2012 through June 2015 Kaiser Permanente Northern California members initiating PrEP. We assessed pharmacy refill adherence discontinuation, decreases estimated glomerular filtration rate (eGFR), sexually transmitted infection (STI)/HIV incidence.Overall, 972...
The incidence of non-melanoma skin cancers (NMSCs), including basal cell (BCC) or squamous carcinoma (SCC), is not well documented among HIV-positive (HIV+) individuals. We identified 6560 HIV+ and 36 821 HIV-negative (HIV−) non-Hispanic white adults who were enrolled followed up in Kaiser Permanente Northern California from 1996 to 2008. first biopsy-proven NMSCs diagnosed during follow-up pathology records. Poisson models estimated rate ratios that compared (overall stratified by recent...
Weight gain following antiretroviral therapy (ART) initiation is common, potentially predisposing some persons with HIV (PWH) to cardio-metabolic disease. We assessed relationships between ART drug class and weight change among treatment-naïve PWH initiating in the North American AIDS Cohort Collaboration on Research Design (NA-ACCORD).Adult, NA-ACCORD integrase strand transfer inhibitor (INSTI), protease (PI) or non-nucleoside reverse-transcriptase (NNRTI)-based on/after 1 January 2007 were...
<h2>Summary</h2><h3>Background</h3> The life expectancy of people with HIV taking antiretroviral therapy (ART) has increased substantially over the past 25 years. Most previous studies were based on data from first few years after starting ART, when mortality is highest. However, many have been successfully treated ART for years, and up-to-date prognosis are needed. We aimed to estimate in adults at least 1 year Europe North America 2015 onwards. <h3>Methods</h3> used Antiretroviral Therapy...
Mortality rates among people with HIV have fallen since 1996 following the widespread availability of effective antiretroviral therapy (ART). Patterns cause-specific mortality are evolving as population ages. We aimed to investigate longitudinal trends in starting ART Europe and North America.
To assess the risk of juvenile-onset recurrent respiratory papillomatosis conferred by a maternal history genital warts in pregnancy, and to identify additional cofactors such as method delivery (cesarean versus vaginal) procedures or complications during pregnancy. A retrospective cohort design was used evaluate infant characteristics associated with among Danish births between 1974 1993. Using data from registries, we identified 3033 Fifty-seven cases were review medical records ear, nose,...
Objectives: To determine the impact of depression on highly active antiretroviral therapy (HAART) adherence and clinical measures investigate if selective serotonin reuptake inhibitors (SSRIs) improve these measures. Design: Retrospective cohort study. Methods: In 2 large health maintenance organizations, we measured effects (with without SSRI use) changes in viral immunologic control among HIV-infected patients starting a new HAART regimen. adherence, HIV RNA levels, CD4 T-cell counts...