A5083470674- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- Adolescent Sexual and Reproductive Health
- Reproductive tract infections research
- Homelessness and Social Issues
- Food Security and Health in Diverse Populations
- Sex work and related issues
- Hepatitis C virus research
- Maternal Mental Health During Pregnancy and Postpartum
- Viral-associated cancers and disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- LGBTQ Health, Identity, and Policy
- Cervical Cancer and HPV Research
- Cardiovascular Disease and Adiposity
- Syphilis Diagnosis and Treatment
- Immune Cell Function and Interaction
- Resilience and Mental Health
- Migration, Health and Trauma
- Cytomegalovirus and herpesvirus research
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Atherosclerosis and Cardiovascular Diseases
Cook County Health and Hospitals System
2016-2025
John H. Stroger, Jr. Hospital of Cook County
2016-2025
Institute for Medical Research
2019-2025
Hektoen Institute
2013-2025
Stanger Hospital
2007-2024
Rush University
2014-2023
Johns Hopkins University
2006-2022
Georgetown University
2002-2022
Equality Now
2019-2022
University of Maryland, Baltimore
2022
Combination antiretroviral therapy (ART) has significantly increased survival among HIV-positive adults in the United States (U.S.) and Canada, but gains life expectancy for this region have not been well characterized. We aim to estimate temporal changes on ART from 2000-2007 U.S. Canada.Participants were North American AIDS Cohort Collaboration Research Design (NA-ACCORD), aged ≥20 years ART. Mortality rates calculated using participants' person-time January 1, 2000 or initiation until...
HIV risk behaviors, susceptibility to acquisition, progression of disease after infection, and response antiretroviral therapy all vary by age. In those living with HIV, current effective treatment has increased the median life expectancy >70 years Biologic, medical, individual, social, societal issues change as one ages but there been only a small amount research in this field. Therefore, Office AIDS Research National Institutes Health commissioned working group develop an outline state...
Objectives. We examined associations between depressive symptoms and AIDS-related mortality after controlling for antiretroviral therapy use, mental health treatment, medication adherence, substance abuse, clinical indicators, demographic factors. Methods. One thousand seven hundred sixteen HIV-seropositive women completed semiannual visits from 1994 through 2001 to clinics at 6 sites. Multivariate Cox logistic regression analyses estimated time death symptom severity. Results. After we...
Objective Lactobacillus dominates the lower genital tract microbiota of many women, producing a low vaginal pH, and is important for healthy pregnancy outcomes protection against several sexually transmitted pathogens. Yet, factors that promote remain poorly understood. We hypothesized amount free glycogen in lumen an determinant colonization pH. Methods Free lavage samples was quantified. Pyrosequencing 16S rRNA gene used to identify from 21 African American women collected over 8–11 years....
Internalization of HIV-related stigma may inhibit a person's ability to manage HIV disease through adherence treatment regimens. Studies, mainly with white men, have suggested an association between internalized and suboptimal antiretroviral therapy (ART). However, there is scarcity research women different racial/ethnic backgrounds on mediating mechanisms in the ART adherence.The Women's Interagency Study (WIHS) multicenter cohort study. Women living complete interviewer-administered...
The purpose of this study was to determine the prevalence and effect domestic violence childhood sexual abuse in women with HIV or at risk for infection.Participants infection enrolled Women's Interagency Study. Childhood abuse; all physical, sexual, coercive by a partner; serostatus; demographic data; substance use habits were assessed.The lifetime 66% 67%, respectively, 1288 357 uninfected women. One quarter reported recent abuse, 31% HIV-seropositive 27% HIV-seronegative abuse. strongly...
To estimate the net (i.e., overall) effect of highly active antiretroviral therapy (HAART) on time to acquired immunodeficiency syndrome (AIDS) or death, authors used inverse probability-of-treatment weighted estimation a marginal structural model, which can appropriately adjust for time-varying confounders affected by prior treatment exposure. Human virus (HIV)-positive men and women (n = 1,498) were followed in two ongoing cohort studies between 1995 2002. Sixty-one percent 918)...
We assessed the association of cigarette smoking with effectiveness highly active antiretroviral therapy (HAART) among low-income women.Data were analyzed from Women's Interagency HIV Study, a multisite longitudinal study up to 7.9 years for 924 women representing 72% all who initiated HAART between July 1, 1995, and September 30, 2003.When Cox's regression was used after control age, race, hepatitis C infection, illicit drug use, previous therapy, AIDS, smokers on had poorer viral responses...
Bacterial vaginosis (BV) is associated with human immunodeficiency virus (HIV) acquisition. We examined the association between BV and BV-associated bacteria expression of HIV in female genital tract.HIV RNA, lactobacilli, Gardnerella vaginalis, Mycoplasma hominis cervicovaginal lavage (CVL) samples were quantified by polymerase chain reaction (PCR). Gynecologic evaluation included Nugent score assessment, Amsel criteria detection other genital-tract infections, dysplasia grading. CD4 cell...
Context Timely testing of women in labor with undocumented human immunodeficiency virus (HIV) status could enable immediate provision antiretroviral prophylaxis.Objectives To determine the feasibility and acceptance rapid HIV among to assess assay performance. Design, Setting, PatientsThe Mother-Infant Rapid Intervention At Delivery (MIRIAD) study implemented 24-hour counseling voluntary for at 16 US hospitals from November 16, 2001, through 15, 2003.A HIV-1 antibody test whole blood was...
Highly active antiretroviral therapy (HAART), in addition to traditional vascular risk factors, may affect coronary heart disease (CHD) individuals with human immunodeficiency virus (HIV) infection.Among HIV-infected (931 men and 1455 women) HIV-uninfected (1099 576 adults, the predicted of CHD was estimated on basis age, sex, lipid blood pressure levels, presence diabetes, smoking status.Among men, 2% had moderate (10-year risk, 15%-25%), 17% high > or = 25% diabetes). Among women, 12%...
Background: Longitudinal associations between patterns of crack cocaine use and progression HIV-1 disease are poorly understood, especially among women. This study explores relationships outcomes in a multicenter cohort infected Methods: Subjects were 1686 HIV-seropositive women enrolled at six US research centers the Women's Interagency HIV Study. Approximately 80% non-white 29% used during period. Cox survival random regression analysis examined biannual observations made April 1996...
Background: The treatment of HIV infection during pregnancy significantly and substantially reduces the risk mother-to-child transmission. Although triple therapy is standard care for management in adults, safety many approved antiretroviral agents not currently established. Methodology: An open-label pilot study conducted Thailand UK saquinavir soft-gel capsules 1200 mg three times daily administered second third trimester combination with local standard-of-care therapy. Infants received...
Parametric and semiparametric competing risks methods were used to estimate proportions, timing, predictors of acquired immune deficiency syndrome (AIDS)-related non-AIDS-related mortality among individuals both positive negative for the human immunodeficiency (HIV) in Multicenter AIDS Cohort Study (MACS) Women's Interagency HIV (WIHS) from 1984 2008 1996 2008, respectively. Among HIV-positive MACS participants, proportion deaths unrelated increased 6% before introduction highly active...
The multidisciplinary team model of HIV care evolved out necessity due to the diverse characteristics and needs people living with disease. Though it is now accepted as international standard care, represents a significant departure from methods for other infectious diseases, debate continues regarding effectiveness its interventions. has been largely uninformed by data; example, little known about relationship between ancillary support services primary outcomes. We hypothesized that...
Objective: To determine the incidence of diabetes mellitus (DM) in a nationally representative cohort HIV-infected women and comparison group HIV-uninfected women. Design: A prospective study between October 2000 March 2006 2088 participants from Women's Interagency HIV Study who did not have evidence DM at enrollment (1524 infected 564 uninfected). Methods: Incident was defined as either having fasting glucose ≥ 1.26 g/l, reporting antidiabetic medication, or diagnosis (with subsequent...
ABSTRACT Bacterial vaginosis (BV) is a clinical syndrome presenting with malodorous vaginal discharge and increased pH. Diagnosis has been based on Amsel criteria direct Gram stain of secretions. Human immunodeficiency virus (HIV)-infected participants in the Women's Interagency HIV Study contributed cervicovaginal lavage (CVL) samples. Lactobacilli, Gardnerella vaginalis , Mycoplasma hominis samples were quantified by PCR. Gynecologic evaluation included Nugent score criterion assessment....
Background: To assess trends in mortality and cause of death for women with HIV, we studied deaths over a 10-year period among participants the Women's Interagency HIV Study, representative US cohort. Methods: Deaths were ascertained by National Death Index Plus match, causes determined certificate. Results: From 1995 through 2004, 710 2792 HIV-infected died. During this interval, standardized ratio fell from high 24.7 1996 to plateau mean 10.3 2001 2004. Over decade, non-AIDS increased...
HIV causes inflammation that can be at least partially corrected by HAART. To determine the qualitative and quantitative nature of cytokine perturbation, we compared patterns in three clinical groups, including HAART responders (HAART), untreated noncontrollers, HIV-uninfected (NEG).Multiplex assays were used to measure 32 cytokines a cross-sectional study participants Women's Interagency Study. Participants from groups included: (n = 17), noncontrollers 14), NEG 17).Several chemokines...
Abuse is highly prevalent among HIV+ women, leading to behaviors, including lower adherence active antiretroviral therapy (HAART) that result in poor health outcomes. Resilience (functioning competently despite adversity) may buffer the negative effects of abuse. This study investigated how resilience interacted with abuse history relation HAART adherence, HIV viral load (VL), and CD4+ cell count a convenience sample 138 women from Ruth M. Rothstein CORE Center/Cook County Health Hospital...
Monocytes and monocyte-derived macrophages promote atherosclerosis through increased inflammation vascular remodeling. This may be especially true in chronic human immunodeficiency virus (HIV) infection. We examined 778 women (74% HIV+) the Women's Interagency HIV Study 503 men (65% Multicenter AIDS Cohort who underwent repeated B-mode carotid artery ultrasound imaging 2004–2013. assessed baseline associations of serum macrophage markers soluble (s)CD163, sCD14, galectin-3 (Gal-3), Gal-3...