A5001266544- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Cardiovascular Disease and Adiposity
- LGBTQ Health, Identity, and Policy
- HIV, Drug Use, Sexual Risk
- Adolescent Sexual and Reproductive Health
- HIV Research and Treatment
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Viral Infections and Immunology Research
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Eating Disorders and Behaviors
- Resilience and Mental Health
- Aortic Thrombus and Embolism
- HIV/AIDS drug development and treatment
- Health disparities and outcomes
- Global Maternal and Child Health
- Homelessness and Social Issues
- Gut microbiota and health
- Hormonal and reproductive studies
- Cardiac Valve Diseases and Treatments
- Kawasaki Disease and Coronary Complications
- Frailty in Older Adults
- Diet and metabolism studies
Johns Hopkins University
2016-2025
Bloomberg (United States)
2018-2024
University of Pittsburgh
2016-2022
Johns Hopkins Medicine
2016-2022
University of Pennsylvania
2022
Brown University
2021
University of Rochester Medical Center
2020
Sabin Vaccine Institute
2018-2019
Pulmonary and Allergy Associates
2019
The Lundquist Institute
2016-2018
Monocytes and monocyte-derived macrophages promote atherosclerosis through increased inflammation vascular remodeling. This may be especially true in chronic human immunodeficiency virus (HIV) infection. We examined 778 women (74% HIV+) the Women's Interagency HIV Study 503 men (65% Multicenter AIDS Cohort who underwent repeated B-mode carotid artery ultrasound imaging 2004–2013. assessed baseline associations of serum macrophage markers soluble (s)CD163, sCD14, galectin-3 (Gal-3), Gal-3...
Background Despite evidence for higher risk of coronary artery disease among HIV+ individuals, the underlying mechanisms are not well understood. We investigated associations inflammatory markers with subclinical in 923 participants Multicenter AIDS Cohort Study (575 and 348 HIV− men) who underwent noncontrast computed tomography scans calcification, majority (n=692) also undergoing angiography. Methods Results Outcomes included presence extent plus angiography analysis presence,...
It is unknown whether disrupted tryptophan catabolism associated with cardiovascular disease (CVD) in human immunodeficiency virus (HIV)–infected individuals. Plasma and kynurenic acid were measured 737 women men (520 HIV+, 217 HIV−) from the Women's Interagency HIV Study Multicenter AIDS Cohort Study. Repeated B-mode carotid artery ultrasound imaging was obtained 2004 through 2013. We examined associations of baseline tryptophan, acid, acid-to-tryptophan (KYNA/TRP) ratio, risk plaque. After...
Alterations in gut microbiota and blood metabolomic profiles have been implicated HIV infection cardiovascular disease. However, it remains unclear whether alterations may contribute to disrupted host relation atherosclerosis, especially the context of infection. We analyzed cross-sectional associations between features carotid artery plaque 361 women with or at high risk (67% HIV+), further integrated plaque-associated microbial plasma lipidomic/metabolomic profiles. Furthermore, 737 men,...
People living with HIV (PLWH) experience increased vulnerability to premature aging and inflammation-associated comorbidities, even when replication is suppressed by antiretroviral therapy (ART). However, the factors associated this remain uncertain. In general population, alterations in N-glycans on IgGs trigger inflammation precede onset of aging-associated diseases. Here, we investigate IgG cross-sectional longitudinal samples from 1214 women men, without HIV. PLWH exhibit an accelerated...
Background HIV-infected persons have an increased risk of atherosclerosis relative to uninfected individuals. Inflammatory processes may contribute this risk. We evaluated the associations 10 biomarkers systemic inflammation (CRP, IL-6, sTNF-αR1 and 2), monocyte activation (CCL2, sCD163, sCD14), coagulation (fibrinogen, D-dimer), endothelial dysfunction (ICAM-1) with subclinical carotid among participants in Multicenter AIDS Cohort Study (MACS). Methods Carotid plaque intima media thickness...
We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine-N-oxide (TMAO) was associated an increased risk in (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05-1.50; P .01). TMAO positively correlated biomarkers monocyte activation inflammation (sCD14, sCD163)....
Background. Hepatitis C virus (HCV) infection may increase the risk of cardiovascular disease (CVD). We evaluated association chronic HCV and coronary atherosclerosis among participants in Multicenter AIDS Cohort Study.
Ceramides have been implicated in the pathophysiology of HIV infection and cardiovascular disease. However, no study, to our knowledge, has evaluated circulating ceramide levels association with subclinical disease risk among HIV-infected individuals. Plasma 4 species (C16:0, C22:0, C24:0, C24:1) were measured 398 women (73% HIV+) 339 men (68% without carotid artery plaques at baseline from Women's Interagency Study Multicenter AIDS Cohort Study. We examined associations between plasma...
Lipid metabolism disruption and excess risk of cardiovascular disease (CVD) have been observed in HIV-infected individuals, but the associations among HIV infection, plasma lipidome, CVD not well understood.To evaluate lipidomic profiles their with carotid artery atherosclerosis individuals without HIV.Prospective analysis Women's Interagency Study Multicenter AIDS Cohort during a 7-year follow-up (from 2004-2006 to 2011-2013) at multicenter cohorts United States. The study included 737...
Abstract Background and Objectives Conversion therapies to minimize same-sex attractions are classified as a dangerous practice by numerous scientific institutions in the United States. These practices may contribute poor long-term psychosocial health, thereby interrupting processes of healthy aging. Few studies have examined differences between persons with without prior experiences conversion therapy. We assessed associations therapy health among midlife older men who sex (MSM; age 40+...
People living with HIV are at higher risk of heart failure and associated left atrial remodeling compared to people without HIV. Mechanisms unclear but have been linked inflammation premature aging. Here we obtain plasma proteomics concurrently cardiac magnetic resonance imaging in two independent study populations identify parallels between HIV-related aging-related immune dysfunction that could contribute clinical failure. We discover a proteomic signature may part reflect or...
Men with HIV have more coronary atherosclerosis than men without HIV. We examined whether plaque progression differed based on serostatus. over a median of 4.5 years (IQR 3.9-4.9) among 548 (n = 313) or 235) from the Multicenter AIDS Cohort Study using CT angiography. Change in volume was calculated for 1) total, 2) calcified, 3) noncalcified, and 4) low attenuation categorized by tertile. Multinomial logistic regression models estimated association between progression. The age 53 old 30%...
Background: Neurocognitive impairment is linked to aging, vascular stiffness, and HIV infection. The role of stiffness in neurocognitive functioning among men with (MWH) remains unclear. This study examined the relationship between carotid artery distensibility decline MWH without (MWoH), while exploring whether serostatus age influenced association. Methods: Baseline cognitive assessments (2004-2013) were measured Multicenter AIDS Cohort Study. Carotid was using B-mode ultrasound. function...
Introduction: The relationships among gut microbial alterations, host inflammation, and cardiac dysfunction remain understudied, particularly in the context of HIV. Hypothesis: We hypothesized that higher abundance pro-inflammatory bacteria is associated with levels circulating inflammatory makers dysfunction. Methods: examined associations features (16S rRNA sequencing) (Echocardiography) 973 women from MACS/WIHS Combined Cohort Study. Cardiac was defined as presence left ventricular...
Aim To describe factors associated with pregnancy desire and dual method use among people living HIV in clinical care sub-Saharan Africa. Design Sexually active HIV-positive adults were enrolled 18 clinics Kenya, Namibia Tanzania. Demographic, reproductive health data captured by interview medical record abstraction. Correlates of desiring a within the next 6 months, [defined as consistent condom together highly effective contraception (hormonal, intrauterine device (IUD), permanent)], those...
Objective HIV-infected (HIV+) individuals may be at increased risk for sudden arrhythmic cardiac death. Some studies have reported an association between HIV infection and prolongation of the electrocardiographic QT interval, a measure ventricular repolarisation, which could potentiate arrhythmias. We aimed to assess whether HIV+ men longer intervals than HIV-uninfected (HIV−) determine factors associated with duration. Methods performed resting 12-lead ECGs in 774 652 HIV− Multicenter AIDS...
Background Lower muscle density on computed tomography (CT) provides a measure of fatty infiltration muscle, an aspect quality that has been associated with metabolic abnormalities, weakness, decreased mobility, and increased fracture risk in older adults. We assessed the cross-sectional relationship between HIV serostatus, age, thigh attenuation, area (CSA). Methods Mean CT-quantified Hounsfield units (HU) bundle CSA were evaluated 368 HIV-infected 145 HIV-uninfected men enrolled...
GlycA, a novel NMR biomarker of inflammation, has been associated with incident cardiovascular disease (CVD) in the general population, but its association CVD among HIV-infected individuals is unknown. We examined associations between GlycA and subclinical coronary plaque HIV-uninfected men participating Multicenter AIDS Cohort Study (MACS).Cross-sectional analysis 935 plasma measurement noncontrast cardiac computed tomography (CT) and/or CT angiography.We used multivariable Poisson linear...
Recent evidence has shown a complex relationship between the gut microbiota, dietary nutrients, and cardiovascular disease (CVD). Trimethylamine-N-oxide (TMAO) production, initiated by been associated with CVD events. We sought to test if this association exists in HIV-infected persons. After adjusting for aspirin use risk factors, men were more likely have coronary stenosis second third TMAO quartiles compared first quartile, but did not differ significantly fourth quartile. found an...