A5043696482- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Gut microbiota and health
- HIV-related health complications and treatments
- Food Security and Health in Diverse Populations
- Health disparities and outcomes
- Peripheral Artery Disease Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Physical Activity and Health
- Diet and metabolism studies
- Diabetes Management and Education
- Oral microbiology and periodontitis research
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- Dental Health and Care Utilization
- Tryptophan and brain disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Smoking Behavior and Cessation
- Diagnosis and Treatment of Venous Diseases
- Early Childhood Education and Development
- Lymphatic System and Diseases
- Migration, Health and Trauma
- Diet, Metabolism, and Disease
New York University
2023-2024
Albert Einstein College of Medicine
2016-2023
The Bronx Defenders
2019-2022
Yeshiva University
2021
Brigham and Women's Hospital
2021
Harvard University
2021
Montefiore Medical Center
2019
Johns Hopkins University
2015-2016
Zhongda Hospital Southeast University
2011
It is unknown whether disrupted tryptophan catabolism associated with cardiovascular disease (CVD) in human immunodeficiency virus (HIV)–infected individuals. Plasma and kynurenic acid were measured 737 women men (520 HIV+, 217 HIV−) from the Women's Interagency HIV Study Multicenter AIDS Cohort Study. Repeated B-mode carotid artery ultrasound imaging was obtained 2004 through 2013. We examined associations of baseline tryptophan, acid, acid-to-tryptophan (KYNA/TRP) ratio, risk plaque. After...
Alterations in gut microbiota (GMB) and host metabolites have been noted individuals with HIV. However, it remains unclear whether alterations GMB related functional groups contribute to disrupted metabolite profiles these individuals.
Obesity and related comorbidities are major health concerns among many US immigrant populations. Emerging evidence suggests a potential involvement of the gut microbiome. Here, we evaluated microbiome features their associations with immigration, dietary intake, obesity in 2640 individuals from population-based study Hispanics/Latinos.The fecal shotgun metagenomics data indicate that greater exposure is associated reduced ɑ-diversity, functions fiber degradation, alterations individual taxa,...
We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine-N-oxide (TMAO) was associated an increased risk in (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05-1.50; P .01). TMAO positively correlated biomarkers monocyte activation inflammation (sCD14, sCD163)....
Rationale: Dietary patterns may alter immune responses and increase asthma risk or affect lung function.Objectives: To examine whether a proinflammatory diet (assessed by the energy-adjusted Inflammatory Index [E-DII]) high dietary quality Alternative Healthy Eating [AHEI-2010]) are associated with current asthma, symptoms, function in Hispanic adults.Methods: This was cross-sectional study of 12,687 adults aged 18 to 76 years who participated Community Health Study/Study Latinos (HCHS/SOL)....
Lipid metabolism disruption and excess risk of cardiovascular disease (CVD) have been observed in HIV-infected individuals, but the associations among HIV infection, plasma lipidome, CVD not well understood.To evaluate lipidomic profiles their with carotid artery atherosclerosis individuals without HIV.Prospective analysis Women's Interagency Study Multicenter AIDS Cohort during a 7-year follow-up (from 2004-2006 to 2011-2013) at multicenter cohorts United States. The study included 737...
Abstract Objectives Antiretroviral therapy (ART) use is associated with disrupted lipid and glucose metabolism in people HIV infection. We aimed to identify plasma species risk of diabetes the context Research Design Methods profiled 211 491 HIV-infected 203 HIV-uninfected participants aged 35 55 years from Women’s Interagency Study Multicenter AIDS Cohort Study. Cox proportional hazards model was used examine associations between baseline incident (166 cases were identified during a median...
US Hispanic/Latino youth are disproportionally affected by the obesity and diabetes. We examined associations of adiposity measures with insulin resistance (IR) hyperglycemia influences sex pubertal development on these associations. performed a cross-sectional analysis 1223 8- to 16-year-old from community-based study in United States (SOL Youth). measured IR (≥75th percentile sex-specific Homeostatic Model Assessment Insulin Resistance) (fasting glucose ≥100 mg/dL or hemoglobin a1c ≥5.7%)....
The purpose of this study was to evaluate the hypothesis that chronic and acculturative stress would be negatively associated with neurocognitive function among middle aged older Hispanics/Latinos. Our analytic sample consisted 3,265 participants (mean age = 56.7 (±0.24)) from Hispanic Community Health Study/Study Latinos who participated in its Sociocultural Ancillary Study. During baseline phase project, were assessed on multiple domains function, completed self-report measures stress....
Cardiovascular disease (CVD) risk factor control is a cornerstone of diabetes mellitus management. Little known about relationships objectively measured sedentary time and physical activity with major CVD in individuals mellitus. We examined associations moderate-to-vigorous reaching goals among US Hispanic/Latino adults mellitus.This cross-sectional analysis included 1699 participants from the Hispanic Community Health Study/Study Latinos (2008-2011). Logistic regression models were used to...
Prior studies indicate that chronic stress is associated with obesity in adults. However, whether parental/caregiver their offspring has not been widely examined Hispanic/Latino populations. In this study, we evaluated the role of caregiver on child and home food environment or lifestyle behaviors explained association.The study included a sample youth caregivers (n = 473) from Study Latinos (SOL) Youth Hispanic Community Health Study/SOL Sociocultural Study, which enrolled children aged...
Background Underuse of cardiovascular medications for secondary prevention among individuals with peripheral artery disease (PAD) has been reported. Little is known about PAD treatment status in the Hispanic/Latino population United States, who may have limited access to health care and worse clinical outcomes than non-Hispanic individuals. Methods Results We studied use therapies 1244 recruited from 4 sites including 826 reported diagnosis by physician 418 coronary alone, Hispanic Community...
Non-alcoholic fatty liver disease (NAFLD) has been associated with increased risk of incident diabetes. But such evidence is lacking in the Hispanic/Latino population, which high prevalence obesity and NAFLD.We conducted a prospective cohort study 6,928 adults background who had no diabetes, did not report excessive alcohol use, hepatitis B C infection at baseline (2008-2011). We estimated ratios (RR) for identified from visit 2 examination by glucose measurements or antidiabetic medication...
Abstract Background Non-genetic factors contribute to differences in diabetes risk across race/ethnic and socioeconomic groups, which raises the question of whether effects predictors are similar populations. We studied incidence primarily non-Hispanic White Framingham Heart Study (FHS, N = 4066) urban, largely immigrant Hispanic Community Health Study/Study Latinos (HCHS/SOL, 6891) Please check if affiliations captured presented correctly. Methods Clinical, behavioral, characteristics were...
Background: Altered gut microbiota has been associated with cognitive dysfunction and Alzheimer’s disease, but little is known among people living HIV. Objective: To examine associations between impairment women or without Methods: This a cross-sectional study of 446 (302 HIV+) who had completed neuropsychological test battery stool sample collected within 1 year. Gut composition was quantified using 16SV4 rRNA gene sequencing microbial functional pathways were predicted PICRUSt. Cognitive...
Individuals with peripheral artery disease (PAD) often have reduced physical activity, which may increase the future risk of diabetes mellitus. Although is a factor for PAD, whether low ankle-brachial index (ABI) predates has not been studied. We examined association ABI incident using Cox proportional hazards models in ARIC Study. was measured 12,247 black and white participants without prevalent at baseline (1987–1989). Incident cases were identified by blood glucose levels three...
Abstract Background Whether physical activity can reduce cardiometabolic risk particularly in understudied populations such as US Hispanics/Latinos is of public health interest. We prospectively examined the association and biomarkers n = 8049 participants Hispanic Community Health Study/Study Latinos, a community-based cohort study 16,415 adults aged 18–74 yr who self-identified Hispanic/Latino from four urban centers. Methods assessed using accelerometry 2008–2011 at visit 1. twice: once 1...
Abstract Aim To examine whether baseline periodontal disease is independently associated with incident prediabetes and diabetes in Hispanics/Latinos the United States. Materials Methods This study examined 7827 individuals, 18–74 years of age without diabetes, from Hispanic Community Health Study/Study Latinos. Participants received a full‐mouth examination at (2008–2011), was classified using Centers for Disease Control Prevention/American Academy Periodontology case definitions. At Visit 2...
The risk of mortgage foreclosure disproportionately burdens Hispanic/Latino populations perpetuating racial disparities in health. In this study, we examined the relationship between area-level risk, homeownership, and prevalence cardiovascular disease factors among participants Hispanic Community Health Study/Study Latinos (HCHS/SOL). HCHS/SOL were age 18–74 years when recruited from four U.S. metropolitan areas. Mortgage was obtained Department Housing Urban Development. Homeownership,...
Background People living with HIV have an increased risk of left ventricular diastolic dysfunction (LVDD) and heart failure. HIV-associated LVDD may reflect both cardiomyocyte systemic metabolic derangements, but the underlying pathways remain unclear. Methods Results To explore such pathways, we conducted a pilot study in Bronx Brooklyn sites WIHS (Women's Interagency Study) who participated concurrent, separate, metabolomics echocardiographic ancillary studies. Liquid chromatography tandem...
Abstract Background & Aims Sedentariness and physical inactiveness are associated with deleterious health outcomes, but their associations liver enzyme elevations remain uncertain. Methods In 10 385 US Hispanics/Latinos from the Hispanic Community Health Study/Study of Latinos, we examined sedentary time moderate‐to‐vigorous activity (MVPA) measured by accelerometers elevations. Elevated alanine aminotransferase (ALT), aspartate γ‐glutamyltransferase (GGT) were defined as highest...
Abstract Aims To examine the association of social capital with periodontal disease severity. Materials and Methods We analysed data obtained from 3,994 men women aged 18–74 years in Hispanic Community Health Study/Study Latinos Sociocultural Ancillary Study (HCHS/SOL SCAS). From 2008 to 2011, dentists assessed periodontitis status a full‐mouth examination. Periodontitis was classified using standardized case definitions. Multivariable logistic regression estimated odds moderate–severe...