Rebecca J. Song
A5002073170- Cardiovascular Health and Risk Factors
- Nutritional Studies and Diet
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Cardiovascular and exercise physiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Kidney Disease and Diabetes
- Cardiovascular Health and Disease Prevention
- Birth, Development, and Health
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Cardiac Health and Mental Health
- Cardiac Imaging and Diagnostics
- Heart rate and cardiovascular health
- Physical Activity and Health
- Agriculture Sustainability and Environmental Impact
- Lipoproteins and Cardiovascular Health
- Nutrition and Health in Aging
- Occupational Health and Performance
- Obesity, Physical Activity, Diet
- Health, Environment, Cognitive Aging
- Frailty in Older Adults
- Climate Change and Health Impacts
Boston University
2018-2024
VA Boston Healthcare System
2016-2023
Paris Cardiovascular Research Center
2022
University College London
2022
The University of Sydney
2022
Zhengzhou University
2022
United States Department of Veterans Affairs
2020
Southerners on New Ground
2017-2019
Background Diabetes mellitus is a risk factor for cardiovascular disease ( CVD ) and has been associated with 2‐ to 4‐fold higher mortality. mellitus–related mortality not reassessed in individuals receiving routine care the United States contemporary era of reduction. Methods Results We retrospectively studied 963 648 adults US Veterans Affairs Healthcare System from 2002 2014; mean follow‐up was 8 years. estimated associations diabetes status hemoglobin A1c (HbA1c) all‐cause using...
Guidelines emphasize screening people with elevated BP for the presence of end-organ damage.
Data on proteomic and metabolomic signatures of healthy dietary patterns are limited. We evaluated the cross-sectional association serum markers with three patterns: Alternative Healthy Eating Index (AHEI), Dietary Approaches to Stop Hypertension (DASH) diet; a Mediterranean-style (MDS) diet. examined participants from Framingham Offspring Study (mean age; 55 years; 52% women) who had complete (n = 1713) 2284) data; using food frequency questionnaires derive pattern indices. Proteins...
Abstract Aims Frailty is associated with an increased risk of all-cause mortality and cardiovascular (CV) events. Limited data exist from the modern era CV prevention on relationship between frailty mortality. We hypothesized that Methods results All US Veterans aged ≥65 years who were regular users Veteran Affairs care 2002 to 2017 included. was defined using a 31-item previously validated index, ranging 0 1. The primary outcome secondary analyses examining events (myocardial infarction,...
End-stage renal disease is associated with a high risk of cardiovascular events. It unknown, however, whether mild-to-moderate kidney dysfunction causally related to coronary heart (CHD) and stroke. Observational analyses were conducted using individual-level data from 4 population sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer Nutrition-Cardiovascular Disease Study], Million Veteran Program, UK Biobank), comprising 648 135 participants...
Ruptured aortic aneurysm and dissections are potentially preventable disorders associated with high mortality. Screening of individuals at risk may translate into elective surgical interventions lowered It is uncertain if the dilation varying degrees aggregates within families.We investigated having thoracic abdominal sizes in highest quartile (measured by computed tomography scans indexed for body size) least 1 parent did so Framingham Heart Study cohorts, estimated incidence rates hazard...
Racial/ethnic health disparities persist among veterans despite comparable access and quality of care. We describe racial/ethnic differences in self-reported characteristics 437,413 men women (mean age (SD) = 64.5 (12.6), 91% men, 79% White) within the Million Veteran Program. The Cochran–Mantel–Haenszel test linear mixed models were used to compare age-standardized frequencies means across race/ethnicity groups, stratified by gender. Black, Hispanic, Other race reported worse self-rated...
Background Data are limited on the association of mildly reduced estimated glomerular filtration rate (eGFR 60–89 mL/min per 1.73 m 2 ) with cardiovascular disease (CVD) in community. Methods and Results We evaluated 3066 Framingham Offspring Study participants (55% women, mean age 58 years), without clinical CVD. Using multivariable regression, we related categories eGFR (80–89, 70–79, or 60–69 versus ≥90 [referent]) to prevalent coronary artery calcium, carotid intima media thickness, left...
<h3>Importance</h3> The associations of estimated cardiorespiratory fitness (eCRF) during midlife with subclinical atherosclerosis, arterial stiffness, incident cardiometabolic disease, and mortality are not well understood. <h3>Objective</h3> To examine eCRF mortality. <h3>Design, Setting, Participants</h3> This cohort study included 2962 participants in the Framingham Study Second Generation (conducted between 1979 2001). Data were analyzed from January 2020 to June 2020....
Objective: To examine the association between intakes of sodium and potassium ratio to incident myocardial infarction stroke. Design, Setting Participants: Prospective cohort study 180,156 Veterans aged 19 107 years with plausible dietary intake measured by food frequency questionnaire (FFQ) who were free cardiovascular disease (CVD) cancer at baseline in VA Million Veteran Program (MVP). Main outcome measures: CVD defined as non-fatal (MI) or acute ischemic stroke (AIS) ascertained using...
Abstract Objective: To examine the association between adherence to plant-based diets and mortality. Design: Prospective study. We calculated a diet index (PDI) by assigning positive scores plant foods reverse animal foods. also created healthful PDI (hPDI) an unhealthful (uPDI) further separating healthy from less-healthy Setting: The VA Million Veteran Program. Participants: 315 919 men women aged 19–104 years who completed FFQ at baseline. Results: documented 31 136 deaths during...
While some epidemiologic studies support the hypothesis that stress can adversely affect fertility, few prospective have assessed association in couples from general population. We used data Pregnancy Study Online, a web-based preconception cohort study of pregnancy planners United States and Canada (2013-2018), to examine between women's men's perceived levels prior conception fecundability. Women (aged 21-45 years) their male partners ≥21 who were attempting without fertility treatment...
Large databases provide an efficient way to analyze patient data. A challenge with these is the inconsistency of ICD codes and a potential for inaccurate ascertainment cases. The purpose this study was develop validate reliable protocol identify cases acute ischemic stroke (AIS) from large national database.Using Veterans Affairs electronic health-record system, Center Medicare Medicaid Services, National Death Index data, we developed algorithm AIS. Using combination inpatient outpatient...
Background Tissue inhibitor of metalloproteinases-1 ( TIMP -1) and procollagen type III aminoterminal peptide are established circulating markers extracellular matrix remodeling associated with cardiovascular disease. The association both biomarkers incident congestive heart failure chronic kidney disease CKD ) in the community is not well studied. Methods Results We measured plasma total -1 levels 922 Framingham participants (mean age, 57 years; 57% women) related to risk...
The risk factors associated with the stages of Coronavirus Disease-2019 (COVID-19) disease progression are not well known. We aim to identify specific each state COVID-19 from SARS-CoV-2 infection through death.We included 648,202 participants Veteran Affairs Million Program (2011-). identified characteristics and 1,809 ICD code-based phenotypes electronic health record. used logistic regression examine association age, sex, body mass index (BMI), race, prevalent progression: infection,...
Background Exercise stress tests are conventionally performed to assess risk of coronary artery disease. Using the FHS (Framingham Heart Study) Offspring cohort, we related blood pressure (BP) and heart rate responses during after submaximal exercise incidence failure (HF). Methods Results We evaluated Framingham Study participants (n=2066; mean age, 58 years; 53% women) who completed 2 stages an test (Bruce protocol) at their seventh examination (1998–2002). measured pulse pressure,...
Background The epidemiology of hypertension subtypes has not been well characterized in the recent era. Methods and Results We delineated prevalence, predictors, progression, prognostic significance 8198 Framingham Heart Study participants (mean age, 46.5 years; 54% women). prevalence was as follows: nonhypertensive (systolic blood pressure [SBP] <140 mm Hg diastolic [DBP] <90 Hg), 79%; isolated systolic (ISH; SBP ≥140 DBP 8%; (SBP ≥90 4%; systolic-diastolic (SDH; 9%. ISH SDH increased with...
Lower circulating homoarginine concentrations have been associated with morbidity and mortality in patients established cardiovascular disease (CVD). We assayed plasma 3331 Framingham Offspring Study participants attending examination cycle six (mean age 58.6 years, 53% women). evaluated correlates of related to incident CVD death. also classified as having higher (upper quartile) versus lower (lower three quartiles) previously asymmetric dimethylarginine (ADMA) concentrations, created...
Abstract Background Non-genetic factors contribute to differences in diabetes risk across race/ethnic and socioeconomic groups, which raises the question of whether effects predictors are similar populations. We studied incidence primarily non-Hispanic White Framingham Heart Study (FHS, N = 4066) urban, largely immigrant Hispanic Community Health Study/Study Latinos (HCHS/SOL, 6891) Please check if affiliations captured presented correctly. Methods Clinical, behavioral, characteristics were...
A healthful plant-based diet was associated with lower risks of coronary heart disease and type 2 diabetes, a favourable profile adiposity-associated biomarkers, while an unhealthful elevated risk cardiometabolic in health professional populations. However, little is known about the associations between dietary patterns cardiovascular (CVD) US veterans.