Robert C. Kaplan
A5058582987- Cardiovascular Health and Risk Factors
- Nutritional Studies and Diet
- HIV-related health complications and treatments
- Cardiovascular Disease and Adiposity
- HIV Research and Treatment
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Atherosclerosis and Cardiovascular Diseases
- Gut microbiota and health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- HIV/AIDS Research and Interventions
- Smoking Behavior and Cessation
- Health, Environment, Cognitive Aging
- Metabolomics and Mass Spectrometry Studies
- Health disparities and outcomes
- Nutrition and Health in Aging
- Systemic Lupus Erythematosus Research
- Health and Lifestyle Studies
- Obstructive Sleep Apnea Research
- HIV/AIDS drug development and treatment
- Physical Activity and Health
- Lipoproteins and Cardiovascular Health
- Dementia and Cognitive Impairment Research
Albert Einstein College of Medicine
2016-2025
Fred Hutch Cancer Center
2018-2025
Rutgers, The State University of New Jersey
2024
Northwell Health
2024
Pulmonary and Critical Care Associates
2024
New York University
2023
The Bronx Defenders
2019-2023
KTH Royal Institute of Technology
2023
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2023
Harvard University
2022
We examine differences in prevalence of diabetes and rates awareness control among adults from diverse Hispanic/Latino backgrounds the Hispanic Community Health Study/Study Latinos (HCHS/SOL).The HCHS/SOL, a prospective, multicenter, population-based study, enrolled four U.S. metropolitan areas 2008 to 2011 16,415 18-74-year-old people descent. Diabetes was defined by either fasting plasma glucose, impaired glucose tolerance 2 h after load, glycosylated hemoglobin (A1C), or documented use...
Tobacco and alcohol use are heritable behaviours associated with 15% 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease injury1-4. These substances used across the globe, yet genome-wide association studies have focused on individuals European ancestries5. Here we leveraged global genetic diversity 3.4 million from four major clines ancestry (approximately 21% non-European) power discovery fine-mapping genomic loci tobacco use, inform function these via...
Background. Individuals infected with human immunodeficiency virus (HIV) have increased risk of cardiovascular events. It is unknown whether T cell activation and senescence, 2 immunologic sequelae HIV infection, are associated vascular disease among HIV-infected adults. Methods. phenotyping carotid ultrasound were assessed 115 women 43 age- race/ethnicity-matched HIV-uninfected controls participating in the Women's Interagency Study. Multivariate analyses used to assess association...
The prevention and control of hypertension is an essential component for reducing the burden cardiovascular diseases. Here we describe prevalence in diverse Hispanic/Latino background groups proportion who are aware their diagnosis, receiving treatment, having under control.The Hispanic Community Health Study/Study Latinos a longitudinal cohort study 16,415 Hispanics/Latinos, aged 18-74 years from 4 US communities (Bronx, NY; Chicago, IL; Miami, FL; San Diego, CA). At baseline (2008-2011)...
Importance Persistent symptoms and disability following SARS-CoV-2 infection, known as post–COVID-19 condition or “long COVID,” are frequently reported pose a substantial personal societal burden. Objective To determine time to recovery infection identify factors associated with by 90 days. Design, Setting, Participants For this prospective cohort study, standardized ascertainment of was conducted starting in April 1, 2020, across 14 ongoing National Institutes Health–funded cohorts that...
To assess the association of HIV infection, disease parameters (including CD4+ T-cell counts, viral load, and AIDS) antiretroviral medication use with subclinical carotid artery atherosclerosis.Cross-sectional study nested within a prospective cohort study.Among participants in Women's Interagency Study (1331 HIV-infected women, 534 HIV-uninfected women) Multicenter AIDS Cohort (600 men, 325 men), we measured lesions common intima-media thickness using B-mode ultrasound. We estimated...
Background: Questions remain about the importance of smoking and cessation after incident myocardial infarction. Objective: To assess association between status risk for recurrent coronary events. Design: Retrospective, population-based, inception cohort study. Setting: Health maintenance organization from 1986 to 1996. Patients: 2619 persons who survived hospital discharge a first Measurements: Relative (RR), assessed by using Cox proportional-hazards regression analysis, events in...
OBJECTIVE Approximately one-third of the adult U.S. population has metabolic syndrome. Its prevalence is highest among Hispanic adults, but variation by Hispanic/Latino background unknown. Our objective was to quantify syndrome men and women 18–74 years age diverse background. RESEARCH DESIGN AND METHODS Two-stage area probability sample households in four locales, yielding 16,319 adults (52% women) who self-identified as Cuban, Dominican, Mexican, Puerto Rican, Central American, or South...
Background. Individuals infected with human immunodeficiency virus (HIV) live longer as a result of effective treatment, but long-term consequences infection, and immunological dysfunction are poorly understood. Methods. We prospectively examined 1011 women (74% HIV-infected) in the Women's Interagency HIV Study 811 men (65% Multicenter AIDS Cohort who underwent repeated B-mode carotid artery ultrasound imaging 2004–2013. Outcomes included changes right common intima-media thickness...
We estimated the prevalence and correlates of mild cognitive impairment (MCI) among middle-aged older diverse Hispanics/Latinos.Middle-aged Hispanics/Latinos enrolled (n = 6377; 50-86 years) in this multisite prospective cohort study were evaluated for MCI using National Institute on Aging-Alzheimer's Association diagnostic criteria.The overall was 9.8%, which varied between Hispanic/Latino groups. Older age, high cardiovascular disease (CVD) risk, elevated depressive symptoms significant...
Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL diverse malignancies. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by expansion hematopoietic cells bearing leukemogenic mutations, predisposes both hematologic malignancy CAD. TERT (which encodes telomerase reverse transcriptase) is the most significantly associated germline locus CHIP in...
Abstract In a multi-stage analysis of 52,436 individuals aged 17-90 across diverse cohorts and biobanks, we train, test, evaluate polygenic risk score (PRS) for hypertension progression. The PRS is trained using genome-wide association studies (GWAS) systolic, diastolic blood pressure, hypertension, respectively. For each trait, selected by optimizing the coefficient variation (CV) estimated effect sizes from multiple potential same GWAS, after which 3 trait-specific PRSs are combined via an...
Menopause is a pivotal period during which loss of ovarian hormones increases cardiometabolic risk and may also influence the gut microbiome. However, menopause-microbiome relationship has not been examined in large study, its implications for disease are unknown. In Hispanic Community Health Study/Study Latinos, population with high burden factors, shotgun metagenomic sequencing was performed on stool from 2,300 participants (295 premenopausal women, 1,027 postmenopausal 978 men), serum...
In a large cohort of 1,772 participants from the Hispanic Community Health Study/Study Latinos with overlapping 16SV4 rRNA gene (bacterial amplicon), ITS1 (fungal and shotgun sequencing data, we demonstrate that amplicon metagenomics offer same level taxonomic accuracy for bacteria at genus even shallow depths. contrast, fungal taxa, did not observe meaningful agreements between results. Finally, show data can be harmonized pooled to yield larger microbiome datasets excellent agreement (<1%...
Circulating metabolite levels may reflect the state of human organism in health and disease, however, genetic architecture metabolites is not fully understood. We have performed a whole-genome sequencing association analysis both common rare variants up to 11,840 multi-ethnic participants from five studies with 1666 circulating metabolites. discovered 1985 novel variant-metabolite associations, validated 761 locus-metabolite associations reported previously. Seventy-nine been replicated,...
The role of rare non-coding variation in complex human phenotypes is still largely unknown. To elucidate the impact variants regulatory elements, we performed a whole-genome sequencing association analysis for height using 333,100 individuals from three datasets: UK Biobank (N = 200,003), TOPMed 87,652) and All Us 45,445). We ( < 0.1% minor-allele-frequency) single-variant aggregate testing regions based on proximal-regulatory, intergenic-regulatory deep-intronic annotation. observed 29...
Abstract Background: Few studies have examined how cancer incidence varies by country of origin among United States Hispanic/Latino adults. Herein, we describe the rates overall and for screen-detectable, tobacco-related, obesity-related cancers 16,415 participants in Hispanic Community Health Study/Study Latinos (HCHS/SOL), an ongoing population-based cohort study adults from diverse backgrounds. Methods: Cohort participant records were linked to state registries New York, Florida,...
The use of single-tablet antiretroviral therapy (ART) regimens and its implications on adherence among HIV-infected women have not been well described.Participants were enrolled in the Women's Interagency HIV Study, a longitudinal study infection US women. We examined semiannual trends regimen ART adherence, defined as self-reported 95% past 6 months, during 2006-2013. In nested cohort study, we assessed comparative effectiveness versus multiple-tablet with respect to virologic suppression,...