A5062925640- Dementia and Cognitive Impairment Research
- Cardiovascular Health and Risk Factors
- Physical Activity and Health
- Health disparities and outcomes
- Health, Environment, Cognitive Aging
- Diversity and Impact of Dance
- Neurobiology of Language and Bilingualism
- Frailty in Older Adults
- Cardiac Health and Mental Health
- Noise Effects and Management
- Air Quality and Health Impacts
- Stress Responses and Cortisol
- Optimism, Hope, and Well-being
- Racial and Ethnic Identity Research
- Cancer-related cognitive impairment studies
- Genetic Associations and Epidemiology
- Aging and Gerontology Research
- Religion and Society Interactions
- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- Music Therapy and Health
- Diverse Music Education Insights
- Stroke Rehabilitation and Recovery
- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
Charles R. Drew University of Medicine and Science
2020-2024
Baylor College of Medicine
2021-2024
Texas Children's Hospital
2024
University of California, San Diego
2018-2021
University of Illinois Chicago
2016-2018
We estimated the prevalence and correlates of mild cognitive impairment (MCI) among middle-aged older diverse Hispanics/Latinos.Middle-aged Hispanics/Latinos enrolled (n = 6377; 50-86 years) in this multisite prospective cohort study were evaluated for MCI using National Institute on Aging-Alzheimer's Association diagnostic criteria.The overall was 9.8%, which varied between Hispanic/Latino groups. Older age, high cardiovascular disease (CVD) risk, elevated depressive symptoms significant...
Abstract Background A better understanding of the pathogenesis polyarticular juvenile idiopathic arthritis (polyJIA) is needed to aide in development data-driven approaches guide selection between therapeutic options. One inflammatory pathway interest JAK-STAT signaling. STAT3 a transcription factor critical differentiation T helper 17 cells (Th17s). Previous studies have demonstrated increased activation adult patients with rheumatoid arthritis, but less known about polyJIA. We hypothesized...
Disparities exist between Latinos and non-Latino Whites in cognitive function. Dance is culturally appropriate challenges individuals physically cognitively, yet the impact of regular dancing on function older has not been examined. A two-group pilot trial was employed among inactive, Latinos. Participants (N = 57) participated BAILAMOS © dance program or a health education program. Cognitive test scores were converted to z-scores measures global cognition specific domains (executive...
Background: Cardiovascular disease is linked to cognitive decline and disorders (e.g., dementia). The evidence based largely on older non-Latino White cohorts. Objective: Examine the association between global vascular risk function among Hispanics/Latinos in United States. Methods: We used data from a large sample of stroke- cardiovascular disease-free, middle-aged with diverse backgrounds ( n=7,650) Hispanic Community Health Study/Study Latinos (HCHS/SOL). compared associations two...
Abstract Background Latinos are the fastest growing minority group of older adult population. Although physical activity (PA) has documented health benefits, less likely to engage in leisure time PA than non-Latino whites. Dance, popular among Latinos, holds promise as a culturally relevant form PA. Purpose To describe self-reported and device-assessed changes result randomized controlled trial BAILAMOS, 4-month Latin dance program with maintenance program, versus education control group....
Physical activity (PA) is a promising method to improve cognition among middle-aged and older adults. Latinos are at high risk for cognitive decline engaging in low levels of PA. Culturally relevant PA interventions critically needed reduce decline. We examined changes performance participating the BAILAMOS™ dance program or health education group compared mediating effects between assignment change domains.Our 8-month randomized controlled trial tested BAILAMOS™, 4-month Latin followed by...
Abstract The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer’s Disease however, its distribution not well-understood among US Latinos. Latinos living in the are highly Amerindian, European African admixed, which varies by region country of origin. However, Latino genetic diversity understudied consequently poorly understood, has significant implications for understanding disease risk nearly one-fifth population. In this report we describe apoE...
Abstract Objectives A well-documented paradox is that Hispanics tend to live longer than non-Hispanic Whites (NHW), despite structural disadvantages. We evaluate whether the “Hispanic paradox” extends more comprehensive longitudinal aging classifications and examine how lifecourse factors relate these groupings. Methods used biennial data (1998–2014) on adults aged 65 years older at baseline from Health Retirement Study. use joint latent class discrete time growth curve modeling identify...
Despite increased risk of cognitive decline in Hispanics/Latinos, research on early markers Alzheimer's disease this group is lacking. Subjective (SCD) may be an marker pathological aging. We investigated associations SCD with objective cognition among a diverse sample Hispanics/Latinos living the United States.SCD was measured Everyday Cognition Short Form (ECog-12) and performance standardized battery 6125 adults aged ≥ 50 years without mild impairment or dementia (x̄age = 63.2 years,...
Hispanics/Latinos have the highest risks for metabolic syndrome (MetS) in U.S. and are also at increased risk Alzheimer disease. In this study, we examined associations among neurocognitive function, MetS, inflammation diverse middle-aged older Hispanics/Latinos.Cross-sectional data (2008-2011) from Hispanic Community Health Study/Study of Latinos (HCHS/SOL) were analyzed to examine between neurocognition MetS (N = 9,136; aged 45-74 years).MetS status was associated with lower global...
Hispanics/Latinos in the United States are more likely to live neighborhoods with greater exposure air pollution and projected have largest increase dementia among race/ethnic minority groups. We examined associations of performance on cognitive function tests Hispanic/Latino adults. used data from San Diego site Hispanic Community Health Study/Study Latinos, an ongoing cohort Hispanics/Latinos. This analysis focused individuals ≥45 years age who completed a neurocognitive battery examining...
Objective The cross-sectional association between accelerometer-measured physical activity (PA), sedentary behaviour (SB) and cardiac structure function is less well described. This study’s primary aim was to compare echocardiographic measures of with accelerometer measured PA SB. Methods Participants included 1206 self-identified Hispanic/Latino men women, age 45–74 years, from the Echocardiographic Study Latinos. Standard M-mode, two-dimensional, spectral, tissue Doppler myocardial strain....
Abstract Introduction Higher cognitive stimulation (CS) is associated with improved cognition. Sources of CS among Hispanics/Latinos are understudied. Methods In the Hispanic Community Health Study/Study Latinos 2008 to 2011 ( n = 9438), we used finite mixture models generate latent profiles, and multivariate linear regressions examine associations cognition in Hispanic/Latino adults (45–74 years). included education, occupation, social network, acculturation. Cognitive measures Six‐Item...
APOE-ɛ4 risk on Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) differs between race/ethnic groups, presumably due to ancestral genomic background surrounding the APOE locus. We studied whether African Amerindian ancestry-enriched genetic variants in region modify effect of alleles Hispanics/Latinos. defined as those common one Hispanic/Latino parental ancestry rare other two. identified such with a predicted moderate impact based SnpEff tool. tested their interaction MCI Study...
Among older adults, poorer cognitive functioning has been associated with impairments in instrumental activities of daily living (IADLs). However, IADL among Hispanics/Latinos is poorly understood. To characterize the relationships between cognition and risk for impairment diverse Hispanics/Latinos. Participants included 6,292 community-dwelling adults from Study Latinos - Investigation Neurocognitive Aging, an ancillary study 45+ year-olds Hispanic Community Health Study/Study Latinos....
We assess whether the cross-sectional associations between moderate-vigorous physical activity (MVPA) and CVD risk factors are modified by various stress types. Complete baseline data from 4,000 participants, ages 18–74 years, of Hispanic Community Health Study/Study Latinos Sociocultural Ancillary Study (HCHS/SOL SCAS) were analyzed using complex survey design methods. Accelerometer-measured MVPA was assessed continuously (average minutes per day). diabetes, hypercholesterolemia,...
Abstract Objectives Identifying sociocultural correlates of neurocognitive dysfunction among Hispanics/Latinos, and their underlying biological pathways, is crucial for understanding disparities in Alzheimer’s disease related dementias. We examined cross-sectional associations between stress neurocognition, the role that metabolic syndrome (MetS) systemic inflammation might play these associations. Method Participants included 3,045 adults aged 45–75 (56% female, education 0–20+ years, 86%...
Neuropsychological instruments are often developed in English and translated to other languages facilitate the clinical evaluation of diverse populations or utilize research environments. However, psychometric equivalence these assessments across language must be demonstrated before can validly compared.To test this equivalence, we applied measurement invariance procedures a subsample (N = 1,708) Hispanic Community Health Survey/Study Latinos (HCHS/SOL) Spanish versions neurocognitive...
Evidence regarding the associations between accelerometer-measured moderate-vigorous physical activity (MVPA) and cardiovascular health (CVH) indicators among Hispanic/Latino adults are unavailable.Examined cross-sectional data from 12,008 aged 18-74 years participating in Hispanic Community Health Study/Study of Latinos. Accelerometer-measured MVPA was assessed categorically dichotomously per 2008 PA guidelines. Adverse ideal CVH were determined by standard cut-points for blood glucose,...
Derive latent profiles of accelerometry-measured moderate-vigorous physical activity (MVPA) for Hispanic/Latino adults, examine associations between MVPA and neurocognition, describe via self-reported MVPA.
Abstract INTRODUCTION Few studies have examined the associations of psychosocial factors with cognitive change in Hispanics/Latinos. METHODS Data from Hispanic Community Health Study/Study Latinos‐Investigation Neurocognitive Aging (HCHS/SOL INCA) and Sociocultural were used ( n = 2,155; ages ≥45 years). Psychosocial exposures included intrapersonal (ethnic identity, optimism, purpose life), interpersonal (family cohesion, familism, social networks, support), discrimination, loneliness,...