A5072291810- Obesity, Physical Activity, Diet
- Cardiovascular Health and Risk Factors
- Nutritional Studies and Diet
- Physical Activity and Health
- Birth, Development, and Health
- Genetic Associations and Epidemiology
- Gut microbiota and health
- Health disparities and outcomes
- Urban Transport and Accessibility
- Cardiovascular Disease and Adiposity
- Regional Development and Environment
- Systemic Lupus Erythematosus Research
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Nutrition, Genetics, and Disease
- Behavioral Health and Interventions
- Epigenetics and DNA Methylation
- Nutrition, Health and Food Behavior
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Folate and B Vitamins Research
- Metabolomics and Mass Spectrometry Studies
- Health, Environment, Cognitive Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Causal Inference Techniques
- Sodium Intake and Health
University of North Carolina at Chapel Hill
2016-2025
University of North Carolina Health Care
2018-2024
National Center for Advancing Translational Sciences
2023
Duke University
2023
China Population and Development Research Center
2013-2023
Communities In Schools of Orange County
2023
National Institute on Minority Health and Health Disparities
2023
National Institutes of Health
2023
Milken Institute
2023
University of Washington
2023
The prevention and control of hypertension is an essential component for reducing the burden cardiovascular diseases. Here we describe prevalence in diverse Hispanic/Latino background groups proportion who are aware their diagnosis, receiving treatment, having under control.The Hispanic Community Health Study/Study Latinos a longitudinal cohort study 16,415 Hispanics/Latinos, aged 18-74 years from 4 US communities (Bronx, NY; Chicago, IL; Miami, FL; San Diego, CA). At baseline (2008-2011)...
OBJECTIVE To examine the secular trends in risk factors, estimate their impact on type 2 diabetes burden from 1991 to 2011, and project next 20 years. RESEARCH DESIGN AND METHODS Risk factor distributions were based data China Health Nutrition Survey 1991–2011. Diabetes cases attributable all nonoptimal levels of each estimated by applying comparative assessment method. RESULTS In high BMI was leading individual for responsible 43.8 million with a population-attributable fraction 46.8%. Low...
<h3>Objective</h3> Prior studies found conflicting results about whether lupus is likely to flare during or after pregnancy. Using a large cohort of pregnant and non-pregnant women with lupus, we estimated the effect pregnancy on disease flares in systemic erythematosus. <h3>Methods</h3> Data were collected Hopkins Lupus Cohort 1987–2015. Women aged 14–45 years >1 measurement activity included. The time-varying exposures classified as pregnancy, postpartum non-pregnant/non-postpartum...
Urbanization is associated with an increased risk for a number of diseases, including obesity, diabetes, and cancer, which all also show associations the microbiome. While microbial community composition has been shown to vary across continents in traditional versus Westernized societies, few studies have examined urban-rural differences neighboring communities within single country undergoing rapid urbanization. In this study, we compared gut microbiome, plasma metabolome, dietary habits,...
Background Few studies have investigated associations of acclerometer-based assessments physical activity (PA) and sedentary behavior (SB) with incidence cardiovascular disease (CVD) its components. This prospective cohort study assessed the accelerometer-measured PA SB total CVD, myocardial infarction, ischemic stroke (IS). Methods Results The authors included 16 031 women aged 62 years older, free adherent accelerometer wear (≥10 hours/day for ≥4 days) from Women's Health Study (mean age,...
Objective In adulthood, excess BMI is associated with cardiovascular disease (CVD); it unknown whether risk differs by trajectories from adolescence to adulthood. Design and Methods The National Longitudinal Study of Adolescent Health, a nationally representative, longitudinal adolescent cohort (mean age: 16.9 years) followed into adulthood 28.8 [n = 13,984 individuals (41,982 observations)] was examined. Separate logistic regression models for diabetes, hypertension, inflammation were used...
Sediment microbial fuel cells (SMFCs) generate electricity through the oxidation of reduced compounds, such as sulfide or organic carbon buried in anoxic sediments. The ability to remove suggests their use remediation sediments impacted by point source matter loading, occurs beneath open pen aquaculture farms. However, for SMFCs be a viable technology they must at scale relevant environmental contamination and impact on sediment geochemistry whole evaluated. Here we address these issues...
While the household context is important for lifestyle behavior interventions, few studies have examined parent-child associations diet and physical activity (PA) changes over time in a rapidly urbanizing country. We aimed to investigate diet, screen time, PA behaviors children their parents living same household, examine association these behaviors.We studied dietary, 5,201 pairs (children aged 7-17y) using longitudinal data from China Health Nutrition Survey (1991, 1993, 1997, 2000, 2004,...
Dramatic increases in child overweight have occurred China. A comprehensive look at trends physical activity and sedentary behaviors among Chinese youth is needed. The study aimed to examine domain-specific behaviors, explore mean distributional changes predicted over time, investigate how vary by residence.Using 2004-2011 China Health Nutrition Survey data, adjusted means for MET-hours/week from hours/week were determined school children (6-18 years), stratifying gender, age group,...
This study aimed to understand how an increase in abdominal adiposity relative overall is associated with blood pressure (BP) change.A sex-stratified mixed linear model was used examine the association (95% CI) between annual changes waist circumference (WC) and systolic diastolic pressure, estimated from two eight repeated measures across 1993-2015 China Health Nutrition Survey, among 5,742 men 5,972 women (18-66 years) no history of antihypertension medication use.The WC change BP remained...
Background Latent class analysis (LCA) identifies distinct groups within a heterogeneous population, but its application to accelerometry-assessed physical activity and sedentary behavior has not been systematically explored. We conducted systematic scoping review describe the of LCA accelerometry. Methods Comprehensive searches in PubMed, Web Science, CINHAL, SPORTDiscus, Embase identified studies published through December 31, 2021. Using Covidence, two researchers independently evaluated...
Data on prospective associations of accelerometer-measured physical activity (PA), sedentary behavior (SB), and mortality among cancer survivors are lacking. Our study examined daily PA (including light, moderate-to-vigorous [MVPA], total PA, steps), SB (sitting time mean bout duration), in the Women's Health Accelerometry Collaboration (WHAC). Postmenopausal women WHAC who reported a diagnosis ≥1 year prior to wearing an ActiGraph GT3X+ hip for ≥4 7 days from 2011-2015 were included....
Introduction: The relationship between physical activity (PA) and sedentary behavior (SB) with mortality among women after a cancer diagnosis is understudied. We examined accelerometer-measured daily PA SB in relation to all-cause cardiovascular disease (CVD) postmenopausal survivors the Women’s Health Accelerometry Collaboration (WHAC). Methods: This study included 2,616 WHAC participants who reported prior baseline. From 2011–2015, wore an ActiGraph GT3X+ on hip for ≥10 hours per day ≥4 of...
Background: Disordered lipid metabolism is highly prevalent in diabetes. Mechanisms have been identified through which lipids can impact glucose metabolism. Previous cohort studies of lipidomics and diabetes often limited to narrow lipidomic coverage or lacked sample diversity sociodemographic characteristics. Methods: Data were from CARDIA, a population-based self-identified Black White race adults, recruited 4 U.S. urban centers 1985-86 (n=5,115). On subset, data generated fasting plasma...
Background: Artificial intelligence (AI) models produce precise interpretations of electrocardiogram (ECG) data and can estimate cardiac age from raw ECG waveforms (ECG-age). Although research suggests potential for cardiovascular disease (CVD) risk assessment, on the short-term repeatability ECG-age over time is scarce. Assessing essential establishing its precision stability. Methods: We trained a convolutional neural network machine learning model to predict using 18,869 patients publicly...
Background: We recently empirically identified 3 novel patterns of cardiovascular risk factor biomarkers with analysis: Renal-inflammatory, thrombo-inflammatory, and dyslipidemic-inflammatory. Hypertension is a major disease factor. Whether these are associated incident hypertension unknown. Objectives: To determine the association between hypertension. Methods: REGARDS recruited 30,239 Black White adults from 48 contiguous US states in 2003-2007 second visit 2013-2016. Baseline fasting...