A5084376543- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Pesticide Exposure and Toxicity
- Pregnancy and Medication Impact
- Childhood Cancer Survivors' Quality of Life
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Per- and polyfluoroalkyl substances research
- Heavy Metal Exposure and Toxicity
- Cancer Risks and Factors
- Air Quality and Health Impacts
- Family Support in Illness
- Reproductive Biology and Fertility
- Anesthesia and Neurotoxicity Research
- Maternal Mental Health During Pregnancy and Postpartum
- Systemic Lupus Erythematosus Research
- Child Nutrition and Water Access
- Thyroid Disorders and Treatments
- Electrolyte and hormonal disorders
- Pharmaceutical studies and practices
- Neonatal Health and Biochemistry
- Reproductive System and Pregnancy
University of North Carolina at Chapel Hill
2016-2025
Johns Hopkins University
2023-2024
Imaging Center
2024
Baylor College of Medicine
2024
Wake Forest University
2024
National Institute on Aging
2024
National Institute of Environmental Health Sciences
2008-2023
Centers for Disease Control and Prevention
2006-2023
Scientific Systems (United States)
2023
Social and Scientific Systems (United States)
2023
Context: Reduced cortisol levels have been linked with vulnerability to posttraumatic stress disorder (PTSD) and the risk factor of parental PTSD in adult offspring Holocaust survivors.
Many phthalates and phenols are hormonally active suspected to alter the course of development.We investigated prenatal exposures phthalate phenol metabolites their associations with body size measures infants at birth.We measured 5 10 urinary in a multiethnic cohort 404 women New York City during third trimester pregnancy recorded birth.Median concentrations were > microg/L for 2 6 monoester metabolites. Concentrations low-molecular-weight monoesters (low-MWP) approximately 5-fold greater...
Experimental and observational studies have reported biological consequences of phthalate exposure relevant to neurodevelopment.Our goal was examine the association prenatal with behavior executive functioning at 4-9 years age.The Mount Sinai Children's Environmental Health Study enrolled a multiethnic population in New York City between 1998 2002 (n = 404). Third-trimester maternal urines were collected analyzed for metabolites. Children 188, n 365 visits) assessed cognitive behavioral...
Background: Prenatal exposure to organophosphate pesticides has been shown negatively affect child neurobehavioral development. Paraoxonase 1 (PON1) is a key enzyme in the metabolism of organophosphates.Objective: We examined relationship between biomarkers exposure, PON1, and cognitive development at ages 12 24 months 6–9 years.Methods: The Mount Sinai Children's Environmental Health Study enrolled multiethnic prenatal population New York City 1998 2002 (n = 404). Third-trimester maternal...
Maternal urinary biomarkers are often used to assess fetal exposure phenols and their precursors. Their effectiveness as a measure of in epidemiological studies depends on variability during pregnancy ability accurately predict exposure.We assessed the relationship between amniotic fluid concentrations nine environmental phenols, reproducibility concentrations, among pregnant women.Seventy-one women referred for amniocentesis were included. urine was collected at time appointment two...
Prenatal exposure to toxic metals or variations in maternal levels of essential elements during pregnancy may be a risk factor for neurodevelopmental disorders such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum (ASD) offspring.We investigated whether measured mid-pregnancy, individually mixtures, were associated with childhood diagnosis ADHD ASD.This study is based on the Norwegian Mother, Father Child Cohort Study included 705 cases, 397 ASD cases 1034 controls....
Prenatal exposures to organophosphate pesticides and polychlorinated biphenyls have been associated with abnormal neonatal behavior and/or primitive reflexes. In 1998-2002, the Mount Sinai Children's Environmental Health Center (New York City) investigated effects of indoor pesticide use exposure on pregnancy outcome child neurodevelopment in an inner-city multiethnic cohort. The Brazelton Neonatal Behavioral Assessment Scale was administered before hospital discharge (n = 311). Maternal...
Abstract: In view of evidence in utero glucocorticoid programming, and our prior observation lower cortisol levels 9‐month‐old infants mothers with posttraumatic stress disorder (PTSD) compared to without PTSD, we undertook an examination the effect maternal stress, as determined by PTSD symptom severity, on behavioral outcomes infant. Methods: Ninety‐eight pregnant women directly exposed World Trade Center (WTC) collapse 9/11 provided salivary samples completed a questionnaire behavior...
We discuss considerations that are essential when evaluating exposure to nonpersistent, semivolatile environmental chemicals such as phthalates and phenols (e.g., bisphenol A). A biomarker should be chosen best represent usual personal exposures not recent, adventitious, or extraneous exposures. Biomarkers selected minimize contamination arising from collection, sampling, analysis procedures. Pharmacokinetics considered; for example, metabolized quickly, urine is the compartment with highest...
Summary: Children in America today are at an unacceptably high risk of developing neurodevelopmental disorders that affect the brain and nervous system including autism, attention deficit hyperactivity disorder, intellectual disabilities, other learning behavioral disabilities. These complex with multiple causes—genetic, social, environmental. The contribution toxic chemicals to these can be prevented. Approach: Leading scientific medical experts, along children's health advocates, came...
Citation Kraus TA, Sperling RS, Engel SM, Lo Y, Kellerman L, Singh T, Loubeau M, Ge Garrido JL, Rodríguez‐García Moran TM. Peripheral blood cytokine profiling during pregnancy and post‐partum periods. Am J Reprod Immunol 2010; 64: 411–426 Problem Pregnancy requires that the maternal immune system adapt to prevent rejection of fetal semi‐allograft. This immunologic adaptation may contribute pregnancy‐related alterations in disease susceptibility severity infections from viral pathogens such...
Background: When a biologic mechanism of interest is anticipated to operate differentially according sex, as often the case in endocrine disruptors research, investigators routinely estimate sex-specific associations. Less attention has been given potential sexual heterogeneity confounder associations with outcomes. relationships covariates outcomes differ commonly applied statistical approaches for estimating disruptor effects may produce divergent estimates. Objectives: We discuss...
Phthalates are hypothesized to cause obesity, but few studies have assessed whether prenatal phthalate exposures related childhood body mass index (BMI).We included 707 children from three prospective cohort enrolled in the US between 1998 and 2006 who had maternal urinary metabolite concentrations measured during pregnancy, measures of weight height at ages 4 7 years. We calculated age- sex-standardized BMI z scores classified with percentiles ≥85 as overweight/obese. used mixed effects...
There is growing concern that phthalate exposures may have an impact on child neurodevelopment. Prenatal exposure to phthalates has been linked with externalizing behaviors and executive functioning defects suggestive of attention-deficit hyperactivity disorder (ADHD) phenotype.We undertook investigation into whether prenatal was associated clinically confirmed ADHD in a population-based nested case-control study the Norwegian Mother Child Cohort (MoBa) between years 2003 2008.Phthalate...
<h3>Objective</h3> Prior studies found conflicting results about whether lupus is likely to flare during or after pregnancy. Using a large cohort of pregnant and non-pregnant women with lupus, we estimated the effect pregnancy on disease flares in systemic erythematosus. <h3>Methods</h3> Data were collected Hopkins Lupus Cohort 1987–2015. Women aged 14–45 years >1 measurement activity included. The time-varying exposures classified as pregnancy, postpartum non-pregnant/non-postpartum...
In Brief OBJECTIVE: To estimate gestational age-specific risks of fetal death in pregnancies complicated by preeclampsia. METHODS: Population-based cohort study comprising all singleton births (N=554,333) without preexisting chronic hypertension recorded the Norwegian Medical Birth Registry from 1999 to 2008. Additional data come a subset preeclamptic enrolled Mother and Child Cohort Study with available medical records (n=3,037). The risk death, expressed per 1,000 fetuses exposed...