A5053552096- Effects and risks of endocrine disrupting chemicals
- Pesticide Exposure and Toxicity
- Heat shock proteins research
- Chemical Safety and Risk Management
- Genetics, Aging, and Longevity in Model Organisms
- Carcinogens and Genotoxicity Assessment
- Ethics in Clinical Research
- Physiological and biochemical adaptations
- Pesticide and Herbicide Environmental Studies
- Neuroscience and Neuropharmacology Research
- Insect and Pesticide Research
- Pharmaceutical industry and healthcare
- Environmental Justice and Health Disparities
- Animal testing and alternatives
- Nanoparticles: synthesis and applications
- Science, Research, and Medicine
- Psychological Well-being and Life Satisfaction
- Toxic Organic Pollutants Impact
- Microplastics and Plastic Pollution
- Agricultural safety and regulations
- Chemical Analysis and Environmental Impact
- Chemistry and Chemical Engineering
- Heavy Metal Exposure and Toxicity
- Healthcare cost, quality, practices
- Health, Environment, Cognitive Aging
Natural Resources Defense Council
2009-2025
George Washington University
2015-2019
Milken Institute
2016
University of Pennsylvania
2012
American University
2010
University of California, Berkeley
2009
University of Maryland, Baltimore
2001-2002
University of Saskatchewan
1993-1999
Saskatchewan Health
1997
The International Agency for Research on Cancer (IARC) Monographs Programme identifies chemicals, drugs, mixtures, occupational exposures, lifestyles and personal habits, physical biological agents that cause cancer in humans has evaluated about 1000 since 1971. are written by ad hoc Working Groups (WGs) of international scientific experts over a period 12 months ending an eight-day meeting. WG evaluates all the publicly available information each substance and, through transparent rigorous...
In this report we present the findings from a nanotoxicology workshop held 6-7 April 2006 at Woodrow Wilson International Center for Scholars in Washington, DC. Over 2 days, 26 scientists government, academia, industry, and nonprofit organizations addressed two specific questions: what information is needed to understand human health impact of engineered nanoparticles how best obtained? To assess hazards near-term, most participants noted need use existing vivo toxicologic tests because...
Summary: Children in America today are at an unacceptably high risk of developing neurodevelopmental disorders that affect the brain and nervous system including autism, attention deficit hyperactivity disorder, intellectual disabilities, other learning behavioral disabilities. These complex with multiple causes—genetic, social, environmental. The contribution toxic chemicals to these can be prevented. Approach: Leading scientific medical experts, along children's health advocates, came...
Abstract The manufacture and production of industrial chemicals continues to increase, with hundreds thousands chemical mixtures used worldwide, leading widespread population exposures resultant health impacts. Low-wealth communities color often bear disproportionate burdens exposure impact; all compounded by regulatory delays the detriment public health. Multiple authoritative bodies scientific consensus groups have called for actions prevent harmful via improved policy approaches. We...
Heat shock genes exhibit complex patterns of spatial and temporal regulation during embryonic development in a wide range organisms. Our laboratory has initiated an analysis heat protein gene expression the zebrafish, model system that is now utilized extensively for examination early vertebrates. We have cloned members zebrafish hsp47, hsp70, hsp90 families shown them to be closely related their counterparts higher Whole mount situ hybridization Northern blot analyses revealed these are...
Hedonic capacity is a dispositional ability to experience pleasure in response stimuli that are typically rewarding. The derive from natural reinforcers has been relatively overlooked as risk factor for adolescent smoking. present study sought provide initial evidence relationship between hedonic and smoking onset escalation. sample was composed of 1,106 adolescents participating prospective longitudinal survey health behaviors. Variables were measured via self-report every 6 months 4 waves...
Members of the eukaryotic hsp90 family function as important molecular chaperones in assembly, folding and activation a select group cellular signalling molecules transcription factors. Several with which interacts, such bHLH factor myoD, are known to be regulators developmental events vertebrates. However, little information is available support any specific role for developing embryos vivo. In this study, we provide first vivo evidence that alpha gene may play process myogenesis. We show...
When the U.S. Environmental Protection Agency (EPA) finalized its 2000 update of toxicological effects vinyl chloride (VC), it was concerned with two issues: classification VC as a carcinogen and numerical estimate potency. In this commentary we describe how EPA review toxicology, which drafted substantial input from chemical industry, weakened safeguards on both points. First, assessment down-plays risks all cancer sites other than liver. Second, potency reduced 10-fold values previously...
Neonicotinoid pesticides ('neonics') – imidacloprid, thiamethoxam, clothianidin, acetamiprid, dinotefuran—are the most widely used class of insecticides in world. They have a neurotoxic mechanism action, similar to nicotine. are detected food, waterways, tap water, and breast milk. We make use non-occupational human pesticide poisoning reports U.S. Environmental Protection Agency (EPA) online Incident Data System (IDS). The data set contains individual incidents, incidents aggregated...
To create a regulatory infrastructure for the effective use of NAMs, CHANGE project aims to organise three workshops Collaborate and Harmonise Assessment Next Generation Evidence. better ensure success approach, organisers invited group participants provide feedback on first workshop held in Oslo 18-20 June 2024. This report represents participants' perspective working methodology serves as companion piece organisers' publication "Improving how we when solving complex research problems:...
Objective The objective of this investigation was to examine how variation in adolescent physical activity is related smoking and alternative tobacco use. Methods Adolescents (N = 1,384) completed a self-report survey every 6 months from ages 14- 18-years old prospective study health behaviors. 8 waves data were analyzed using General Growth Mixture Modeling (GGMM) Results GGMM identified five trajectories including stable higher (SHPA), decreased (DPA), regular (SRPA), curvilinear (CPA),...
A major toxic effect associated with methylmercury (MeHg) exposure in developing humans is damage to the nervous system, which involves inhibition of cell migration, particularly cerebellum. The mechanisms by MeHg impairs neural migration are not fully known, especially at low doses. In this paper we report on a novel method for observing and quantitating movement individual cells primary cultures murine neonatal cerebellar cells, offers an opportunity assess role endogenous exogenous...
Abstract Background Critical knowledge of what we know about health and disease, risk factors, causation, prevention, treatment, derives from epidemiology. Unfortunately, its methods language can be misused improperly applied. A repertoire methods, techniques, arguments, tactics are used by some people to manipulate science, usually in the service powerful interests, particularly those with a financial stake related toxic agents. Such interests work foment uncertainty, cast doubt, mislead...
The toxic anti-thyroidic chemical perchlorate, used in rocket fuel, has leached from military dumpsites into public drinking water sources, contaminating the at dangerous levels many states. Department of Defense and its contractors such as Lockheed Martin are using obfuscation to wage a campaign slow or block Environmental Protection Agency regulatory measures that might cost them billions dollars cleanup liability. influence DOD over EPA is cause for extreme concern.
Abstract Background In February 2021, over one hundred scientists and policy experts participated in a web-based Workshop to discuss the ways that divergent evaluations of evidence scientific uncertainties are used delay timely protection human health environment from exposures hazardous agents. The arose previous workshop organized by European Environment Agency (EEA) 2008 which also drew on case studies EEA reports ‘Late Lessons Early Warnings’ (2001, 2013). These documented dozens agents...