A5100748004- Nutritional Studies and Diet
- Gut microbiota and health
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Reproductive Biology and Fertility
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Consumer Attitudes and Food Labeling
- Ovarian function and disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Pain Mechanisms and Treatments
- Heavy Metal Exposure and Toxicity
- Metabolomics and Mass Spectrometry Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- Obesity, Physical Activity, Diet
- Neuroscience and Neuropharmacology Research
- Eicosanoids and Hypertension Pharmacology
- Effects and risks of endocrine disrupting chemicals
- Cancer Genomics and Diagnostics
- Receptor Mechanisms and Signaling
- Colorectal Cancer Screening and Detection
- Autophagy in Disease and Therapy
- Dementia and Cognitive Impairment Research
Lanzhou University
2010-2025
First Hospital of Lanzhou University
2017-2025
Beijing City University
2023-2025
Zhejiang University
2014-2025
Zhengzhou University
2025
First Affiliated Hospital Zhejiang University
2019-2025
Harvard University
2021-2024
Massachusetts General Hospital
2021-2024
First Affiliated Hospital of Soochow University
2021-2024
Fujian Normal University
2024
Background & AimsDiet may contribute to the increasing incidence of colorectal cancer (CRC) before age 50 (early-onset CRC). Microbial metabolism dietary sulfur produces hydrogen sulfide (H2S), a gastrointestinal carcinogen that cannot be easily measured at scale. As result, evidence supporting its role in early neoplasia is lacking.MethodsWe evaluated long-term adherence microbial diet, index defined priori based on increased abundance 43 bacterial species involved with metabolism, risk CRC...
Bisphenol A (BPA), an environmental endocrine disruptor (EDC), has been implicated in impairing intestinal and male reproductive dysfunction. The efficacy of gut microbiota modulation for BPA-exposed testicular dysfunction yet to be verified through research. Therefore, this study explored the potential mixed probiotics restoring spermatogenesis damage gut-testis axis under BPA exposure. We selected two strains (Lactobacillus rhamnosus Lactobacillus plantarum) with removal properties vitro...
Lubrication surfaces reduce the risk of cross-contamination and enhance long-term stability medical devices, which holds significance in realm antifouling materials. However, complexity constructing micronano structures to immobilize lubricating fluids fluorine content typically found silane coupling agents restrict their widespread adoption. In this study, we prepared a biomimetic coating (BLC) through one-step self-assembly octadecyltrichlorosilane oil infusion. The BLC exhibits pronounced...
<h3>Importance</h3> Sulfur-metabolizing bacteria that reduce dietary sulfur to hydrogen sulfide have been associated with colorectal cancer (CRC). However, there are limited studies investigating the association between diet and sulfur-metabolizing in development of CRC. <h3>Objective</h3> To develop a score correlates gut sulfur–metabolizing examine its CRC risk. <h3>Design, Setting, Participants</h3> This prospective cohort study included data from Health Professionals Follow-up Study...
To assess whether maternal ultra-processed food intake during peripregnancy and the child rearing period is associated with offspring risk of overweight or obesity childhood adolescence. Population based prospective cohort study. The Nurses' Health Study II (NHSII) Growing Up Today (GUTS I II) in United States. 19 958 mother-child (45% boys, aged 7-17 years at study enrollment) pairs a median follow-up 4 (interquartile range 2-5 years) until age 18 onset obesity, including subsample 2925...
Abstract The existence of cancer stem cells is widely acknowledged as the underlying cause for challenging curability and high relapse rates observed in various tumor types, including non-small cell lung (NSCLC). Despite extensive research on numerous therapeutic targets NSCLC treatment, strategies to effectively combat stemness achieve a definitive cure are still not well defined. primary objective this study was examine mechanism through which Fructose-1,6-bisphosphatase 1 (FBP1),...
Gut microbiota has been identified as a key player in the development of alcoholic liver disease (ALD). Targeting gut with probiotic intervention will be an attractive approach to prevent ALD. Here, we investigated effects Bifidobacterium breve ATCC15700 (ATCC15700) on injury and mice exposed chronic alcohol intake. Our results showed that oral administration significantly decreased endotoxemia, maintained immune homeostasis, alleviated alcohol-induced injury. also promoted intestinal...
ABSTRACT Tapetum, the innermost layer of anther wall, provides essential nutrients and materials for pollen development. Timely degradation tapetal cells is a prerequisite normal development in flowering plants. Tapetal facilitate male gametogenesis by providing cellular contents after highly coordinated programmed cell death (PCD). regulated transcriptional network. However, signaling pathway(s) involved this process are poorly understood. In study, we report that mitogen‐activated protein...
This study aimed to understand how an increase in abdominal adiposity relative overall is associated with blood pressure (BP) change.A sex-stratified mixed linear model was used examine the association (95% CI) between annual changes waist circumference (WC) and systolic diastolic pressure, estimated from two eight repeated measures across 1993-2015 China Health Nutrition Survey, among 5,742 men 5,972 women (18-66 years) no history of antihypertension medication use.The WC change BP remained...
<h3>Importance</h3> Delayed graft function (DGF) is a risk factor for acute rejection and failure after kidney transplant. Previous studies have suggested that dexmedetomidine may be renoprotective, but whether the use of would improve allograft unknown. <h3>Objective</h3> To investigate effects perioperative on DGF following donation-after-cardiac-death (DCD) <h3>Design, Setting, Participants</h3> This single-center, double-blind, placebo-controlled randomized clinical trial was conducted...
The gut microbiome is increasingly recognized to play a role in cognition and dementia. Antibiotic use impacts the has been linked with chronic disease. Despite these data, there no evidence supporting an association between long-term antibiotic adults cognitive function. We conducted prospective population-based cohort study among 14,542 participants Nurses’ Health Study II who completed self-administered computerized neuropsychological test battery 2014–2018. Multivariate linear regression...
Abstract Background The gut microbiome regulates host energy balance and adiposity-related metabolic consequences, but it remains unknown how the modulates body weight response to physical activity (PA). Methods Nested in Health Professionals Follow-up Study, a subcohort of 307 healthy men (mean[SD] age, 70[4] years) provided stool blood samples 2012–2013. Data from cohort long-term follow-ups accelerometer, doubly labeled water, plasma biomarker measurements during time collection were used...
Intrauterine adhesion (IUA) is a common gynecological disease with limited therapeutic options. Dulaglutide long-acting glucagon-like peptide-1 (GLP-1) analog some anti-fibrotic and anti-inflammatory properties; however, its action on IUA remains uncertain. The purpose of the experiments in this study was to explore effect dulaglutide elucidate mechanism provide new ideas for clinical treatment IUA. An mouse model established via mechanical curettage inflammation induction; mice received...
The role of diet and the gut microbiome in etiopathogenesis irritable bowel syndrome (IBS) is not fully understood. Therefore, we investigated interplay between dietary risk factors microbiota IBS subtypes using a food frequency questionnaire stool metagenome data from 969 participants aged 18–65 years ZOE PREDICT 1 study, an intervention study designed to predict postprandial metabolic responses. We identified individuals with subtype according Rome III criteria based on predominant habits...
Dietary patterns contribute to overall health and diseases of ageing but are understudied in older adults. As such, we first aimed develop dietary indices quantify Mediterranean Diet Score (MDS) utilisation Ultra-processed Food (UPF) intake a well-characterised cohort relatively healthy community-dwelling Australian Second, understand the relationship between these scores association with prevalent cardiometabolic disease frailty. Our major findings that this population adults, (a)...
Epidemiological studies suggest a positive association between obesity and fecal short-chain fatty acids (SCFAs) produced by microbial fermentation of dietary carbohydrates, while animal models increased energy harvest through colonic SCFA production in obesity. However, there is lack human population-based with intake data, plasma SCFAs, gut microbial, anthropometric data. In 490 Chinese adults aged 30-68 years, we examined the associations key SCFAs (butyrate/isobutyrate, isovalerate,...
Animal studies have revealed gut microbial and metabolic pathways of blood pressure (BP) regulation, yet few epidemiological collected microbiota metabolomics data in the same individuals. In a population-based, Chinese cohort who did not report antihypertension medication use (30-69 years, 54% women), thus minimizing BP treatment effects, we examined multivariable-adjusted (eg, diet, physical activity, smoking, kidney function), cross-sectional associations between measures (16S rRNA...
Abstract N6-methyladenosine (m6A) catalyzed by METTL3 regulates the maternal-to-zygotic transition in zebrafish and mice. However, role mechanism of METTL3-mediated m6A methylation blastocyst development remains unclear. Here, we show that sustains porcine via negatively modulating autophagy. We found reduced levels triggered knockdown caused embryonic arrest during morula-blastocyst developmental defects trophectoderm cells. Intriguingly, overexpression early embryos resulted increased...
Abstract Background Dietary magnesium deficiency, which is common in modern diet, has been associated with osteoarthritis (OA) susceptibility. Despite this clinical association, no study addressed if dietary deficiency accelerates OA development, especially at molecular level. This aimed to explore aggravating effects of on cartilage damage an injury-induced murine model and determine the underlying mechanism. Methods Twelve-week-old C57BL/6J mice subject modeling were randomized into...
Synaptotagmin III (Syt3) is a Ca2+-dependent membrane-traffic protein that highly concentrated in synaptic plasma membranes and affects plasticity by regulating post-synaptic receptor endocytosis. Here, we show Syt3 upregulated the penumbra after ischemia/reperfusion (I/R) injury. Knockdown of protects against I/R injury, promotes recovery motor function, inhibits cognitive decline. Overexpression exerts opposite effects. Mechanistically, injury augments Syt3-GluA2 interactions, decreases...