A5100395040- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Pharmacological Effects of Natural Compounds
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition and Health in Aging
- Ginseng Biological Effects and Applications
- Estrogen and related hormone effects
- Traditional Chinese Medicine Analysis
- Muscle Physiology and Disorders
- Tryptophan and brain disorders
- Alcohol Consumption and Health Effects
- Sirtuins and Resveratrol in Medicine
- Heme Oxygenase-1 and Carbon Monoxide
- Bone Metabolism and Diseases
- Nanoparticle-Based Drug Delivery
- Traumatic Brain Injury and Neurovascular Disturbances
- Connective tissue disorders research
- Curcumin's Biomedical Applications
- Prenatal Substance Exposure Effects
- Agricultural safety and regulations
- Quinazolinone synthesis and applications
- Bioactive natural compounds
Harvard University
2020-2025
Southern Medical University
2023-2025
Sun Yat-sen Memorial Hospital
2024-2025
University of Science and Technology of China
2025
Sun Yat-sen University
2022-2024
Nanjing Brain Hospital
2024
Nanjing Medical University
2024
Massachusetts General Hospital
2023
Chinese PLA General Hospital
2023
Shenyang Pharmaceutical University
2012-2023
To observe the effects of resveratrol (Res) on antioxidative function and estrogen level in an Alzheimer's disease (AD) mouse model.First, we examined Res AD mice model. SAMP8 were selected as model, normal-aging SAMR1 used control group. The model randomly divided into three groups: a group, high-dose group (40mg/kg, intraperitoneal (ip)), low-dose (20mg/kg, ip). After receiving medication for 15 days, subjected to water maze test assess their spatial discrimination. spectrophotometric...
Skeletal muscle atrophy in chronic kidney disease (CKD) leads to a decline quality of life and increased risk morbidity mortality. We have obtained evidence that oxidative stress is essential the progression CKD-related atrophy. Whether Saikosaponin A D, two emerging antioxidants extracted from Bupleurum chinense DC, alleviate remains be further studied. The purpose this study was investigate effects mechanisms these components on CKD complicated with atrophy.In research, dystrophy model...
Abstract: Surface modification of nanocarriers with amphiphilic polymer polyethylene glycol (PEG), known as PEGylation, is regarded a major breakthrough in the application nanocarriers. However, PEGylated (including liposomes and polymeric nanoparticles) induce what referred to “accelerated blood clearance (ABC) phenomenon” upon repeated injection consequently they lose their sustained circulation characteristics. Despite this, present authors are not aware any reports accelerated due for...
Abstract Generalized arterial calcification of infancy (GACI) is associated with widespread and stenoses caused by mutations in ENPP1 . encodes for ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), which cleaves ATP to generate inorganic pyrophosphate (PP i ) adenosine monophosphate (AMP) extracellularly. The current study was designed define the prevalence GACI individuals identify mechanism through deficiency causes intimal proliferation. Furthermore, we aimed effectively prevent...
Abstract Background The gut microbiome regulates host energy balance and adiposity-related metabolic consequences, but it remains unknown how the modulates body weight response to physical activity (PA). Methods Nested in Health Professionals Follow-up Study, a subcohort of 307 healthy men (mean[SD] age, 70[4] years) provided stool blood samples 2012–2013. Data from cohort long-term follow-ups accelerometer, doubly labeled water, plasma biomarker measurements during time collection were used...
G protein-coupled estrogen receptor (GPER) is recently identified as a membrane-associated that mediates non-genomic effects of estrogen. Our previous immunohistochemistry study found an association between GPER and the proliferation epithelial ovarian cancer. However, contributions mechanisms in cancers are not clear. We have examined role α (ERα)-negative/GPER positive OVCAR5 cancer cell line. MTT assay was used to detect proliferation. BrdU incorporation measure cells S-phase. Protein...
Abstract Colorectal cancer (CRC) is the third most common and lethal type worldwide. Although CRC incidence in older population has decreased many countries, early-onset cases (< 50 years age, EOCRC) have been rapidly increasing globally. The fecal microbiome reproducibly associated with CRC. However, differences according to age of onset, stage, anatomic location, genomic instability remain only minimally explored. Here, we integrated data generated from ONCOBIOME consortium, Cancer...
Microbial fermentation has been widely applied in traditional Chinese medicine (TCM) for thousands of years China. Various beneficial effects applications TCM or herbals have reported, such as enhanced anti-ovarian cancer, antioxidative activity, and neuroprotective effects. Ge-Gen-Qin-Lian decoction (GQD), a classic formula, used to treat type 2 diabetes mellitus In this study, GQD was fermented with Saccharomyces cerevisiae, the antidiabetic activities overall chemical profiles raw (FGQD)...
In this study, we investigated the impact of endogenous hydrogen sulfide (H2S) on toll-like receptors (TLRs)-mediated inflammatory response and apoptosis in renal ischemia-reperfusion injury (IRI). Twenty-four male Wistar rats were randomly divided into four groups: sham, IR, IR + propargylglycine (PAG) hydroxylamine (HA). After right nephrectomy, given saline for sham group, PAG group HA through left artery 20 min. Five minutes after drug administration, all except underwent 45 min ischemia...
Increased incidence of arrhythmias in women after menopause has been widely documented, which is considered to be related estrogen (E 2 ) deficiency induced cardiac electrophysiological abnormalities.However, its molecular mechanism remains incompletely clear.In the present study, we found conduction blockage post-menopausal rats.Thereafter, results showed that gap junctions were impaired and Connexin43 (Cx43) expression was reduced myocardium rats.The phenomenon also observed ovariectomized...
Objective: Metabolites in body fluids, such as lactate, glucose, and creatinine, have been measured by conventional methods to evaluate physical function performance or athletic status. The objectives of the current study were explore novel metabolite biomarkers professional swimmers with different competition levels using nuclear magnetic resonance (NMR) metabolomics, try establish a model identify status predict competitive potential. Methods: Serum samples collected from 103 elite 84...
This study is aimed to design and synthesize a prodrug of 5-aminosalicylic acid evaluate its ameliorative effect on experimental ulcerative colitis (UC).5-Aminosalicylic acid-alanine (5-ASA-ALA) was synthesized characterized. Its stability conducted in rat plasma the gastrointestinal tract environment, transport characteristic assessed using Caco-2 cells. colon-targeting property evaluated by pharmacokinetic study, incubation studies. A series indicators were used investigate therapeutic...
Suanzaoren Decoction(SZRD) is a classical formula for the clinical treatment of insomnia. This study analyzed effect SZRD on endogenous metabolites in insomnia rats based metabonomics and thereby explored anti-insomnia mechanism SZRD. To be specific, DL-4-chlorophenylalanine(PCPA) was used to induce rats. Then pathological changes liver brain were observed biochemical indexes such as 5-hydroxytryptamine(5-HT), dopamine(DA), glutamate(Glu), γ-aminobutyric acid(GABA), norepinephrine(NE)...
Backgrounds: High-altitude pulmonary edema (HAPE) is a life-threatening disease without effective drugs. Caffeine small molecule compound with antioxidant biological activity used to treat respiratory distress syndrome. However, it unclear whether caffeine plays role in alleviating HAPE. Methods: We combined series of experiments and label-free quantitative proteomics analysis detect the effect on treating HAPE explore its mechanism vivo vitro. Results: Dry wet weight ratio HE staining...