A5013406285- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Ion channel regulation and function
- Cardiac Fibrosis and Remodeling
- Cardiomyopathy and Myosin Studies
- Global Cancer Incidence and Screening
- Signaling Pathways in Disease
- Receptor Mechanisms and Signaling
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Cancer Risks and Factors
- Hemodynamic Monitoring and Therapy
- Gallbladder and Bile Duct Disorders
- Diverticular Disease and Complications
- Appendicitis Diagnosis and Management
- Phytochemistry and biological activities of Ficus species
- Peptidase Inhibition and Analysis
- Whipple's Disease and Interleukins
- Lymphoma Diagnosis and Treatment
- Acute Kidney Injury Research
- Muscle and Compartmental Disorders
- Cell death mechanisms and regulation
- Chromatin Remodeling and Cancer
- Ultrasound in Clinical Applications
- Biliary and Gastrointestinal Fistulas
Dubbo Hospital
2022-2025
University of North Carolina at Chapel Hill
2021-2024
Howard University Hospital
2023
Wollongong Hospital
2022
University College London
2019
Sydney Hospital
2016
University of Cape Town
2011
University of Cincinnati
2004-2008
Cincinnati Children's Hospital Medical Center
2004-2008
University of Cincinnati Medical Center
2006-2007
Following myocardial infarction, nonischemic myocyte death results in infarct expansion, loss, and ventricular dysfunction. Here, we demonstrate that a specific proapoptotic gene, Bnip3, minimizes remodeling the mouse, despite having no effect on early or late size. We evaluated effects of ablating Bnip3 cardiomyocyte death, size, after surgical ischemia/reperfusion (IR) injury mice. Immediately following IR, significant differences were observed between Bnip3–/– WT However, at 2 days...
Abnormal calcium cycling, characteristic of experimental and human heart failure, is associated with impaired sarcoplasmic reticulum uptake activity. This reflects decreases in the cAMP-pathway signaling increases type 1 phosphatase The increased protein activity partially due to dephosphorylation inactivation its inhibitor-1, promoting phospholamban inhibition calcium-pump. Indeed, cardiac-specific expression a constitutively active inhibitor-1 results selective enhancement phosphorylation...
Background— Pathological cardiac hypertrophy inevitably remodels, leading to functional decompensation. Although modulation of apoptosis-regulating genes occurs in hypertrophy, a causal role for programmed cardiomyocyte death left ventricular (LV) remodeling has not been established. Methods and Results— We targeted the gene proapoptotic Nix, which is transcriptionally upregulated pressure overload Gq-dependent hypertrophies, mouse germ line or specifically cardiomyocytes (knockout [KO])...
The inflammatory response to Mycobacterium tuberculosis (M.tb) at the site of disease is Th1 driven. Whether Th17 cytokines, IL-17 and IL-22, contribute this in humans unknown. We hypothesized that IL-22 pleural pericardial sites human (TB). studied effusions, established TB sites, from HIV-uninfected patients. Levels soluble cytokines were measured by ELISA MMP-9 luminex. Bronchoalveolar lavage or mycobacteria-specific T cell cytokine expression was analyzed intracellular staining. not...
ABSTRACT Background The impact of socioeconomic status and distance to hospital on negative appendicectomy rates is unknown. These factors have been shown be important predictors health in a rural setting. Objective To determine whether road were risk for appendicectomy. Methods A retrospective analysis all appendicectomies at large Australia between January 2018 December 2022 was performed. Patients' data extracted from electronic medical records. Regression modelling performed surgical...
Caspase-1/interleukin-converting enzyme (ICE) is a cysteine protease traditionally considered to have importance as an inflammatory mediator, but not apoptotic effector. Because of the dual functions this caspase, pathophysiological impact its reported upregulation in hypertrophy and heart failure known. Here, consequences increased myocardial expression procaspase-1 were examined on normal ischemically injured heart. In unstressed mouse hearts with 30-fold increase content, unprocessed was...
Hundreds of signaling molecules have been assigned critical roles in the pathogenesis myocardial hypertrophy and heart failure based on cardiac phenotypes from alpha-myosin heavy chain-directed overexpression mice. Because permanent ventricular transgene expression this system begins during a period rapid physiological neonatal growth, resulting are combined consequences effects normal trophic influences. We used temporally-defined forced gene to investigate synergy between postnatal growth...
Background— Phospholamban (PLN) is an inhibitor of the Ca 2+ affinity sarcoplasmic reticulum (SR) -ATPase (SERCA2). The amino acid sequence PLN highly conserved, and although all species contain asparagine (Asn), human unique in containing lysine (Lys) at 27. Methods Results— Human was introduced null background. Expression PLN, similar levels to mouse wild-type resulted significant decreases SERCA2 for , attributed spatial conformation this form increases its monomeric active unit compared...
AbstractIn the present study, we evaluated tuftsin bearing nystatin liposomes for their potential against an isolate of Candida albicans (C. albicans) showing less in vivo susceptibility to amphotericin B (Amp B). The liposomised-Amp higher doses was found be effective elimination susceptible strain C. JMCR) Balb/c mice, but may not recommended due toxicity constraints. On other hand, liposomal shown possess efficacy as compared that Amp B, and pertinent treatment JMCR strain. data work...
Perforation of the gallbladder and spillage gallstones can be a cause ongoing morbidity mortality in patients post cholecystectomy. We report on an unusual case 58-year-old male who developed right upper quadrant lump 8 years after laparoscopic cholecystectomy which was eventually determined to abscess from retained gallstone that had become embedded musculature his abdominal wall. have also discussed some considerations taken surgical management this case.
Intussusception is a rare presentation in adult population and usually occurs secondary to an underlying pathology. We report unusual case of 28-year-old female who developed colo-colonic intussusception Burkitt lymphoma which was managed with extended right hemicolectomy. The further complicated by segment small bowel malignant adhesion prosthetic mesh requiring resection the involved bowel. have discussed significance this as well general considerations surgical management intussusception.
Background: The pathogenesis of idiopathic premature ventricular contractions (PVCs) may differ between patients with left- vs right- outflow tract (LVOT; RVOT) PVCs. We hypothesized that PVCs LVOT origin would be associated a higher prevalence inflammatory conditions, such as coronary artery disease (CAD) and aortic sclerosis (AS), elevation in the biomarker, neutrophil-to-lymphocyte ratio (NLR). Research Question: Is NLR PVCs? Aim: To compare clinical factors versus right-outflow Methods:...
Chylothorax is a relatively rare condition characterized by the accumulation of chyle, milky lymphatic fluid, within pleural space. It occurs because disruption or obstruction thoracic duct its tributaries, leading to chyle leakage into cavity. We present an interesting case chylothorax that occurred as complication post-chest tube insertion. A 66-year-old patient presented with hypotension and shortness breath. Initial chest X-ray in emergency room showed right-sided hydropneumothorax...
Abstract Blunt abdominal injury can be a cause of significant morbidity and mortality in patients who have sustained trauma even at low velocity. We report on an unusual case 50-year-old male developed traumatic spigelian hernia caecal perforation after falling off pushbike impacting the handlebar. also discussed some considerations taken assessment surgical management this case.