A prospective observational study of cohorts patients undergoing hip replacement (30), knee (31), and spinal nerve root decompressive surgery (30) were interviewed pre-operatively to identify factors which might correlate with potentially predict severe post-operative pain dissatisfaction analgesic management. The comprised 33% females averaged 64 years, while the 45% female older (mean 71 years) 43% 50 years. three groups similar respect all other pre-operative variables. Pain intensity was...

Abstract To assess mechanisms that cause generalized osteoporosis in rheumatoid arthritis (RA), we measured bone mineral density (BMD) by dual photon absorptiometry the lumbar spine and femoral neck of 111 patients with RA. BMD was significantly reduced at both sites these patients. Physical activity correlated RA, found, multiple regression analysis, to be a significant predictor female Multiparity exerted protective effect on density. Prednisolone (mean dosage 8 mg/day) not associated...

To compare the efficacy of a local anesthetic cream and music distraction in reducing or preventing pain from needle puncture (intravenous cannulation) children. A secondary aim was to examine influence age on report behavior therapeutic outcome.Children aged 4 16 years (N = 180) who were undergo surgery under general anesthesia via intravenous cannulation randomly allocated one three interventions. The comparison lidocaine-prilocaine emulsion (EMLA, Astra) placebo double-blind....

Fear of inducing generalised osteoporosis is one reason why corticosteroids are withheld in patients with rheumatoid arthritis (RA). No studies, however, have directly measured bone density such at clinically relevant sites. To assess this risk we mineral the lumbar spine and femoral neck by dual photon absorptiometry 84 RA, 44 whom had been treated low dose prednis(ol)one (mean +/- SE 8.0 0.5 mg/day; mean duration treatment 89.6 12.0 months). There were significant reductions (lumbar 9.6%,...

Low dose corticosteroids are effective in suppressing synovitis rheumatoid arthritis (RA), but there remains concern about their side effects, particularly osteoporosis. To examine the effects of low on bone loss RA mineral density (BMD) was measured lumbar spine and hip for up to two years 15 patients treated with these agents (mean prednis(ol)one 6.6 mg/day). not receiving them, age matched controls. The initial BMD at both skeletal sites significantly reduced patient groups compared mean...

Abstract Sex hormones have important effects on bone, especially in postmenopausal women. These may be of particular significance patients with rheumatoid arthritis (RA), who a high frequency osteoporosis. To examine this, we measured estrogen and androgen concentrations bone mineral density (BMD) 49 women RA normal Compared the controls, had significantly reduced levels estrone (median 18 pmoles/liter versus 49; P < 0.001), dehydroepiandosterone sulfate (DHEAS) 0.3 μmoles/liter 2.0;...

The main objective was to compare the utility of Faces Pain Scale (Bieri et al., 1990) with three alternative self-report measures pain intensity in children, as well ratings based on observations child's behavior.Fifty children used 4 scales rate severity needle from routine immunization. Using videotapes, pain-related behavior coded detailed fashion, and a subset sample were also rated globally by 60 registered pediatric nurses.Faces Scale; Poker Chip Tool; Visual Analogue Toy; Verbal...

lntersubject differences in the volume of distribution, whole body clearance, and steady‐state plasma concentrations salicylic acid (SA) were studied a series patients with rheumatoid arthritis healthy control subjects. The measurement concentration SA 12 hr after an oral dose 1.2 gm aspirin appears predictive success long‐term dosage aspirin. Concentrations below 5 u‐g/ml this single‐dose test associated failure to achieve therapeutic (above 150 u‐g/ml) during therapy approximately 4.8 per...

Chlorambucil is useful in patients with rheumatoid arthritis (RA) refractory to other agents but there concern about the risk of haematological malignancy this agent. A retrospective survey was performed assess incidence all types 39 treated chlorambucil (mean daily dose 4.25 mg, mean duration treatment 25 months). These were compared 30 RA who received contemporaneously, purine analogues azathioprine or 6-mercaptopurine 100 24 Eight and one patient receiving developed cutaneous (p = 0.03)....

The coexistence of anti-La (SS-B) and anti-Ro (SS-A) autoantibodies in pSS is probably explained by intermolecular spreading autoimmunity toward different components the La/Ro ribonucleoprotein (RNP). In order to evaluate role HLA class II phenotype controlling diversification this autoantibody response, 80 patients with were typed polymerase chain reaction sequence-specific oligonucleotide (PCR-SSO) at loci DRB1, DQA1 DQB1. Serum samples examined for counterimmunoelectrophoresis ELISA using...

Abstract The aim of this study was to identify differences in the medical management and clinical outcome a group elderly patients admitted designated geriatric assessment unit (GAU) or two general units (GMUs). A prospective randomised controlled trial undertaken 267 aged 70 years over (mean age = 78.3 years). Following discharge from hospital, were followed up at three monthly intervals for total 12 months. At time discharge, no significant found inpatient management, length stay,...

Two studies were conducted to determine the effect of aspirin administration on serum concentrations indomethacin in human subjects. Indomethacin was determined specifically free its metabolites by spectrofluorometry following heptane extraction. In Study 1, mean levels and estimated plasma half‐times elimination after 50 mg. oral doses 8 normal volunteers not significantly changed concurrent (3.6 Gm. per day) indomethacin. Following a fasting dose, half‐time without 1.82 hours that with...

In the use of anti-inflammatory compounds, sustained serum levels are thought to be related drug efficacy. This study shows that frequent clinical administration indomethacin can result in and food antacid may have important modifying effects on concentrations. After oral ingestion by fasting subjects, rapidly appeared serum, usually reaching peak concentrations 30 90 minutes. Food delayed decreased mean level; slightly enhanced subsequent With multiple dose schedules plateau were reached...

This study examined the relative effectiveness of EMG biofeedback, applied relaxation training and a combined procedure in management chronic, upper extremity cumulative trauma disorder. Forty-eight patients with history about 5-6 years pain were randomly assigned to 1 4 treatment conditions, namely training, approach or wait-list control. Treatments conducted on an individual basis, twice per week for weeks. Patients all 3 conditions showed significant short-term reductions psychopathology...

A questionnaire survey of 363 children and young adults with juvenile arthritis was conducted to assess the relations among disease severity, psychosocial functioning, adjustment in three age groups—primary school, high adult. Parents were surveyed separately determine which characteristics ill child at different ages most significantly impact well-being family. Indices psychologic functioning severity associated primary school groups, whereas measures social relationships strongly only...

The simultaneous disposition of the enantiomers ibuprofen in synovial fluid and plasma was studied eight patients with arthritis. Concentrations active S-enantiomer exceeded those R-enantiomer at all times ratio S to R concentrations being 2.1 ± 0.3 (mean SE). Synovial fluctuated much less than from 5.4 hours for R-ibuprofen 5.5 0.6 S-ibuprofen. Pharmacokinetic analysis suggested that, although diffuse into primarily unbound form, there may be significant diffusion out protein-bound form...