A5076064890- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Effects of Radiation Exposure
- COVID-19 and healthcare impacts
- T-cell and B-cell Immunology
- Ultrasound and Hyperthermia Applications
- Brain Metastases and Treatment
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- Long-Term Effects of COVID-19
- Receptor Mechanisms and Signaling
- Extracellular vesicles in disease
- Skin Protection and Aging
- Nicotinic Acetylcholine Receptors Study
- melanin and skin pigmentation
- Cutaneous Melanoma Detection and Management
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Multiple Myeloma Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Immune cells in cancer
- Heat shock proteins research
- Colorectal and Anal Carcinomas
Emory University
2016-2025
Emory and Henry College
2024
Emory Healthcare
2017-2023
University of Alabama at Birmingham
2007-2020
University of Chicago
2019
Dermatology Research Center
2010
Aligarh Muslim University
2003-2005
Immunotherapeutic PD-1–targeted therapies require CD28 to promote cancer cell killing.
Significance Therapies that harness the immune system have recently been approved for cancer treatment. Identification of biomarkers to monitor or predict patients’ responses immunotherapies would help guide treatment decisions. Herein we analyzed changes in peripheral blood T cells from lung patients receiving immunotherapy blocking PD-1 inhibitory pathway. We detected CD8 T-cell following most patients. In addition, our data suggest an increase proliferation PD-1+ within 4 wk initiation...
Background Radiotherapy (RT) has been shown to stimulate an antitumor immune response in irradiated tumors as well unirradiated distant sites (abscopal effect). Previous studies have demonstrated a role for the tumor-draining lymph node (LN) mediating anti-programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) stimulated response. Here, we investigated whether LN is also important RT alone abscopal Methods We used subcutaneous modified B16F10 flank tumor model injected bilaterally. Our...
Background Individuals of advanced age with comorbidities face a higher risk death from coronavirus disease 2019 (COVID‐19), especially once they are ventilator‐dependent. Respiratory decline in patients COVID‐19 is precipitated by lung‐mediated aberrant immune cytokine storm. Low‐dose lung radiation was used to treat pneumonia the pre‐antibiotic era. Radiation immunomodulatory effects may improve outcomes for select COVID‐19. Methods A single‐institution trial evaluating safety and efficacy...
CD8 T cells play an essential role in antitumor immunity and chronic viral infections. Recent findings have delineated the differentiation pathway of accordance with progenitor-progeny relationship TCF1 + stem-like Tim-3 − more differentiated cells. Here, we investigated characteristics isolated from several murine tumor models human lung cancer samples terms phenotypic transcriptional features as well their location compared to virus-specific chronically lymphocytic choriomeningitis virus...
The immune system encodes information about the severity of a pathogenic threat in quantity and type memory cells it forms. This encoding emerges from lymphocyte decisions to maintain or lose self-renewal potential during challenge. By tracking CD8+ T at single-cell clonal lineage level using time-resolved transcriptomics, quantitative live imaging, an acute infection model, we find that will early after antigen recognition. However, following pathogen clearance, may regain if initially...
Phase 1 clinical trials have established low-dose, whole-lung radiation therapy (LD-RT) as safe for patients with coronavirus disease 2019 (COVID-19)-related pneumonia. By focally dampening cytokine hyperactivation, LD-RT may improve outcomes through immunomodulation.
To examine COVID-19 mRNA vaccine-induced binding and neutralizing antibody responses in patients with non-small-cell lung cancer (NSCLC) to SARS-CoV-2 614D (wild type [WT]) strain variants of concern after the primary 2-dose booster vaccination.
Abstract Toll-like receptors (TLR) activate multiple steps in inflammatory reactions innate immune responses. They also signals that are critically involved the initiation of adaptive Many tumorigenic chemicals have been associated with endotoxin hypersensitivity mediated through TLR4. To determine role TLR4 cutaneous skin carcinogenesis, we treated TLR4-deficient C3H/HeJ mice and TLR4-normal C3H/HeN carcinogenic polyaromatic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA). developed more...
Abstract Proteomic analysis of murine skin has shown that a variety heat shock proteins (HSPs) are constitutively expressed in the skin. Using allergic contact hypersensitivity as model, we investigated role two proteins, HSP27 and HSP70, induction cutaneous cell-mediated immune responses. Immunohistochemical examination specimens showed was present epidermis HSP70 both dermis. Inhibition produced reduction 1-fluoro-2,4-dinitrobenzene response resulted Ag-specific unresponsiveness. Treatment...
Abstract Toll‐like receptors (TLRs) activate signals that are critically involved in innate immune responses and contribute to the initiation of adaptive responses. Resveratrol ( trans ‐3,5,4‐trihydroxystilbene), a polyphenol found red grapes several other plant sources, is an effective chemopreventive agent cutaneous chemical carcinogenesis. In this study, we investigated whether TLR4 was required for action resveratrol DMBA skin For purpose, mice with normal deficient function were...
PurposeMelanoma brain metastases (MBM) occur in ∼50% of melanoma patients. Although both radiation therapy (RT) and immune checkpoint inhibitor (ICI) are used alone or combination for MBM treatment, the role this how these treatments could best be sequenced remains unclear.Methods MaterialsWe conducted a retrospective analysis patients with resected who underwent treatment RT, ICI, RT ICI. Among latter, we specifically investigated differential gene expression via RNA-sequencing between...
Abstract The role that cell-mediated immune responses play during cutaneous carcinogenesis has received little attention. In this study, we evaluated the contribution of CD4+ and CD8+ T cells in C3H/HeN mice were subjected to a two-stage 7,12-dimethylbenz(a)anthracene (DMBA) initiation, 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion skin protocol. CD8 knockout (CD8−/−) mice, allergic contact hypersensitivity DMBA was reduced compared with wild-type (WT) mice. On other hand, CD4...
Abstract Purpose: Combination of chemotherapy with programmed cell death 1 (PD-1) blockade is a front-line treatment for lung cancer. However, it remains unknown whether and how affects the response exhausted CD8 T cells to PD-1 blockade. Experimental Design: We used well-established mouse model T-cell exhaustion chronic lymphocytic choriomeningitis virus (LCMV) infection assess effect (cisplatin+pemetrexed) on blockade, in absence impact antigen release presentation observed tumor models....
Intensity-modulated radiation therapy (IMRT) reirradiation of nonmetastatic recurrent or second primary head and neck squamous cell carcinoma (HNSCC) results in poor progression-free survival (PFS) overall (OS).
Toll-like receptors (TLRs) activate signals that are critically involved in the initiation of adaptive immune responses and many tumorigenic chemicals have been associated with activation those pathways. To determine role TLR-4 (TLR4) mammary carcinogenesis, we subjected TLR4 deficient wild type (WT) mice to oral gavage carcinogenic polyaromatic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA). developed more tumors relative WT mice. T cells produced elevated levels IL-17 lower IFN-γ IL-12...