A5085137065- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Cell Adhesion Molecules Research
- HER2/EGFR in Cancer Research
- Head and Neck Cancer Studies
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- S100 Proteins and Annexins
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Polyamine Metabolism and Applications
- Advanced biosensing and bioanalysis techniques
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- Advanced Biosensing Techniques and Applications
Emory University
2014-2023
Winship Cancer Institute
2012-2021
AID Atlanta
2019
Cancer Institute (WIA)
2014
Georgia Institute of Technology
2012
In-Q-Tel
2012
Gold nanorods (AuNRs)-assisted plasmonic photothermal therapy (AuNRs-PPTT) is a promising strategy for combating cancer in which AuNRs absorb near-infrared light and convert it into heat, causing cell death mainly by apoptosis and/or necrosis. Developing valid PPTT that induces avoids necrosis vivo exploring its molecular mechanism of action great importance. Furthermore, assessment the long-term fate after treatment critical clinical use. We first optimized size, surface modification...
DNA origami is a promising molecular delivery system for variety of therapeutic applications including cancer therapy, given its capability to fabricate homogeneous nanostructures whose physicochemical properties (size, shape, surface chemistry) can be precisely tailored. However, the correlation between DNA-origami design and internalization efficiency in different cell lines remains elusive. We investigated cellular uptake four (DONs) with programmed sizes shapes multiple human lines. The...
In this study, magnetic iron oxide nanoparticle induced hyperthermia is applied for treatment of head and neck cancer using a mouse xenograft model human (Tu212 cell line).A system heating nanoparticles was developed by alternating fields.Both theoretical simulation experimental studies were performed to verify the thermotherapy effect.Experimental results showed that temperature tumor center has dramatically elevated from around room about 40 o C within first 5-10 minutes.Pathological...
The emergence of resistance to EGF receptor (EGFR) inhibitor therapy is a major clinical problem for patients with non-small cell lung cancer (NSCLC). mechanisms underlying tumor inhibitors the kinase activity EGFR are not fully understood. Here, we found that inhibition by erlotinib induces STAT3 phosphorylation at Tyr705 in association increased Bcl2/Bcl-XL both mRNA and protein levels various human cells. PTPMeg2 physiologic phosphatase can directly dephosphorylate site. Intriguingly,...
Abstract Short interfering RNA (siRNA) is a promising molecular tool for cancer therapy, but its clinical success limited by the lack of robust in vivo delivery systems. Rationally designed DNA nanoparticles (DNPs) have emerged as facile vehicles because their physicochemical properties can be precisely controlled. Nonetheless, few studies used DNPs to deliver siRNAs vivo, and none has demonstrated therapeutic efficacy. Herein, we constructed number rectangular tubular shapes with varied...
Epidermal growth factor receptor (EGFR) is extensively expressed in head and neck cancer. However, EGFR-targeted therapy has only modest efficacy cancer, through mechanisms that are not fully understood. Here, we found inhibition of EGFR by erlotinib stimulated phosphorylation activation STAT3 leading to increased Bcl2/Bcl-XL expression cancer cells, which may dampen the therapeutic against Erlotinib-enhanced results, at least part, from suppression its physiological phosphatase, PTPMeg2....
Abstract Purpose: Our previous work suggested that HER3 inhibition sensitizes head and neck squamous cell carcinoma (HNSCC) to EGFR with cetuximab. This study aimed define the role of in cetuximab resistance antitumor mechanisms EGFR/HER3 dual targeting HNSCC. Experimental Design: We treated cetuximab-resistant HNSCC UMSCC1-C parental UMSCC1-P lines anti-EGFR antibody cetuximab, anti-HER3 MM-121, their combination. assessed activities HER2, HER3, downstream signaling pathways by Western...
The proposed macroscopic optical histopathology includes a broad-band light source which is selected to illuminate the tissue glass slide of suspicious pathology, and hyperspectral camera that captures all wavelength bands from 450 950 nm. system has been trained classify each histologic based on predetermined pathology with having within range wavelengths. This technology able capture both spatial spectral data tissue. Highly metastatic human head neck cancer cells were transplanted nude...
The EGFR monoclonal antibody cetuximab is the only approved targeted agent for treating head and neck squamous cell carcinoma (HNSCC). Yet resistance to has hindered its activity in this disease. Intrinsic or compensatory HER3 signaling may contribute resistance. To investigate therapeutic benefit of combining MM-121/SAR256212, an anti-HER3 antibody, with HNSCC, we initially screened 12 HNSCC lines total phosphorylated levels four HER receptors. We also investigated combination MM-121...
The determination of tumor margins during surgical resection remains a challenging task. A complete removal malignant tissue and conservation healthy is important for the preservation organ function, patient satisfaction, quality life. Visual inspection palpation not sufficient discriminating between normal types. Hyperspectral imaging (HSI) technology has potential to noninvasively delineate margin can be used as an intra-operative visual aid tool. Since histological images provide ground...
BACKGROUND Although heregulin and human epidermal growth factor receptor 3 (HER3) are frequently expressed at high levels in patients with head neck cancer, their prognostic value remains unclear. The authors explored the significance of heregulin/HER3 expression oropharyngeal squamous cell carcinoma (OPSCC), taking into account other HER family members as well p16 status. METHODS Ninety‐six primary tumor specimens from OPSCC were retrospectively collected analyzed for messenger RNA (mRNA)...
Epidermal growth factor receptor (EGFR) has been reported to downregulate E-cadherin (E-cad); however, whether the downregulation of E-cad any effect on EGFR expression not elucidated. Our previous studies have found an inverse correlation between and in tissue specimens squamous cell carcinoma head neck (SCCHN). To understand biological mechanisms underlying this clinical observation, we knocked down utilizing siRNA four SCCHN lines.It was observed that upregulated compared with control...
This study aimed to understand the prognostic value of integrin β1 expression in head and neck squamous cell carcinoma (HNSCC) mechanism underlying its association with metastatic HNSCC.
Journal Article Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts Get access Shijun Zhu, Zhu Department Hematology Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA. Fax: +1 404 778 5016; Tel: 727 3457 Search for other works by this author on: Oxford Academic Google Scholar Terry W. Moore, Moore Institute Drug Discovery, USADepartment Chemistry, USA Xiaoqian Lin, Lin Nao Morii, Morii Alessandra Mancini,...
// You-Take Oh 1 , Ping Yue Dongsheng Wang Jing-Shan Tong 2 Zhuo G. Chen Fadlo R. Khuri Shi-Yong Sun Department of Hematology and Medical Oncology, Emory University School Medicine Winship Cancer Institute, Atlanta, GA, USA Pharmacology Chemical Biology, Pittsburgh Institute Medicine, Pittsburgh, PA, Correspondence to: Sun, e-mail: ssun@emory.edu Keywords: death receptor 5, invasion, metastasis, caspase-8, TRAF2 Received: September 16, 2015 Accepted: 22, Published: October 15, ABSTRACT The...
Microtubule-associated serine/threonine kinase 1 (MAST1) is a central driver of cisplatin resistance in human cancers. However, the molecular mechanism regulating MAST1 levels cisplatin-resistant tumors unknown. Through proteomics screen, we identified heat shock protein 90 B (hsp90B) chaperone as direct binding partner essential for its stabilization. Targeting hsp90B sensitized cancer cells to predominantly through destabilization. Mechanistically, interaction with blocked ubiquitination...
A continuous-flow single-cell mechanotyping method which can decouple the cell size-dependent effect from compressibility-dependent is presented.
Abstract FAT1 is frequently mutated in head and neck squamous cell carcinoma (HNSCC), but the biological clinical effects of mutations HNSCC remain to be fully elucidated. We investigated landscape altered protein gene expression associated with outcomes patients HNSCC. mutation was stratified information from The Cancer Genome Atlas databases more than 200 proteins or phosphorylated sites. significantly prevalent among HPV(−), female, older enriched oral, larynx, hypopharynx primary tumors....