A5011870485- Cell Adhesion Molecules Research
- Hydrocarbon exploration and reservoir analysis
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- S100 Proteins and Annexins
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- Cell death mechanisms and regulation
- Cancer-related gene regulation
- Circular RNAs in diseases
- Fungal Biology and Applications
- Microtubule and mitosis dynamics
- Polysaccharides and Plant Cell Walls
- Chronic Obstructive Pulmonary Disease (COPD) Research
- HIV Research and Treatment
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- ATP Synthase and ATPases Research
- Sirtuins and Resveratrol in Medicine
- Hydraulic Fracturing and Reservoir Analysis
- RNA modifications and cancer
- Protease and Inhibitor Mechanisms
- Enhanced Oil Recovery Techniques
- HER2/EGFR in Cancer Research
Shandong University
2013-2025
Guilin Medical University
2025
Tianjin University of Traditional Chinese Medicine
2025
The Fifth People’s Hospital of Suzhou
2025
Affiliated Hospital of Hangzhou Normal University
2022-2024
Jilin Agricultural University
2018-2024
Pudong Medical Center
2013-2024
Fudan University
2013-2024
Guangzhou Medical University
2021-2024
Beihua University
2014-2024
Multi-scale (nano-to-micro) three-dimensional CT imaging was used to characterize the distribution and texture of micro-scale pore throats in tight sandstone reservoirs Triassic Yanchang Formation, Ordos Basin. First, low-resolution Micro-CT reflect micro-pore core column with a diameter 2.54 cm. Then, some samples 65 μm derived from different areas according characteristics scanned by high-resolution Nano-CT. Thus, model nano-scale micro-pores reestablished permebility porosity data sample...
Salinomycin is perhaps the first promising compound that was discovered through high throughput screening in cancer stem cells. This novel agent can selectively eliminate breast and other cells, though mechanism of action remains unclear. In this study, we found salinomycin induced autophagy human non-small cell lung (NSCLC) Furthermore, demonstrated stimulated endoplasmic reticulum stress mediated via ATF4-DDIT3/CHOP-TRIB3-AKT1-MTOR axis. Moreover, by played a prosurvival role NSCLC cells...
Parthenolide (PTL) is a sesquiterpene lactone which can induce apoptosis in cancer cells and eradicate stem such as leukemia cells, prostate tumor-initiating so on. However, the mechanism remains largely unclear. Lung were treated with parthenolide cell lysates prepared to detect given proteins by Western Blot analysis, survival was assayed SRB MTT assay. Cell cycle evaluated DNA flow cytometry analysis. TNFRSF10B, PMAIP1, ATF4 DDIT3 genes knocked down siRNA technique. Apoptosis using...
Abstract Background Many cancers evade immune surveillance by overexpressing PD-L1. PD-L1 interacted with its receptor PD-1, resulting in reduction of T cell proliferation and activation thereafter cancer death mediated T-lymphocyte. Understanding the mechanisms that regulate was vital importance for checkpoint blockade therapy (ICBT). Methods Human non-small lung cells 293FT were used to investigate function USP22 upon CSN5 WB, Immunoprecipitation, Immunofluorescence Flow cytometry...
Type 2 diabetes mellitus is a global disease that endangers human health, and the need for development of nontoxic treatment candidates urgent. In present work, one homogeneous polysaccharide from Inonotus obliquus (IN) was isolated, protective effect mechanism IN on type were investigated aspects intestinal barrier. mainly consisted 9 monosaccharides with Mw 373 kDa. attenuated body weight loss, alleviated pathological damage, suppressed production proinflammatory cytokines. Additionally,...
Sirtuins (a class III histone deacetylase) have emerged as novel targets for cancer therapy. Salermide, a reverse amide compound that inhibits Sirtuin 1 (Sirt1) and 2 (Sirt2), has been shown to induce apoptosis in human cells. The mechanism underlying cellular apoptotic signalling by salermide remains unclear. In this study, we show up-regulates the expression of death receptor 5 (DR5) non-small cell lung (NSCLC) Blocking DR5 gene silencing technology results decrease activated forms several...
Abstract Background Immunotherapy has been shown to be a promising strategy against human cancers. A better understanding of the immune regulation in hepatocellular carcinoma (HCC) could help development immunotherapy HCC. The epidermal growth factor receptor (EGFR) signaling is frequently activated HCC and plays important roles tumorigenesis. However, its role immunity still largely unknown. This study aimed investigate impact EGFR on programmed death‐ligand 1 (PD‐L1) leukocyte antigen...
Deregulation of alternative splicing is implicated as a relevant source molecular heterogeneity in cancer. However, the targets and intrinsic mechanisms hepatocarcinogenesis are largely unknown. Here, we report functional impact Splicing Regulatory Glutamine/Lysine-Rich Protein 1 (SREK1) variant its regulator, Serine/arginine-rich factor 10 (SRSF10). HCC patients with poor prognosis express higher levels exon 10-inclusive SREK1 (SREK1L). SREK1L can sustain BLOC1S5-TXNDC5 (B-T) expression,...
Brain expressed X-linked gene 2 (BEX2) encoded protein was originally identified to promote transcription by interacting with several factors in the DNA-binding complexes. Recently, BEX2 found be localized cytosol and/or mitochondria and regulate apoptosis cancer cells tumor growth. However, molecular mechanism underlying its roles remains unclear. Here, we report that crotonylated plays an important role inhibiting chemotherapeutic agent-induced via enhancing mitophagy human lung cells....
Pemetrexed, a folate antimetabolite, combined with cisplatin is used as first-line therapy for malignant pleural mesothelioma (MPM) and locally advanced or metastatic non-small-cell lung cancer (NSCLC). Pemetrexed arrests cell cycle by inhibiting three enzymes in purine pyrimidine synthesis that are necessary DNA synthesis. also promotes apoptosis target cells, but little known about its mechanism cells. We have previously shown pemetrexed can result endoplasmic reticulum (ER) stress, it...
BIX-01294, an euchromatic histone-lysine N-methyltransferase 2 (EHMT2) inhibitor, has been reported to induce apoptosis in human neuroblastoma cells and inhibit the proliferation of bladder cancer cells. However, definite mechanism mediated by BIX-01294 remains unclear. In present study, we found that induced caspase-dependent Moreover, our data show stimulates endoplasmic reticulum stress (ER stress) up-regulated expression PMAIP1 through DDIT3 up-regulation. Furthermore, down-regulation...
CFLARL, also known as c-FLIPL, is a critical anti-apoptotic protein that inhibits activation of caspase 8 in mammalian cells. Previous studies have shown arginine 122 CFLARL can be mono-methylated. However, the precise role methyltransferase remains unknown. PRMT5 and PRMT1, which are important members PRMT family, catalyze transfer methyl groups to substrate proteins. monomethylate or symmetrically dimethylate residues, while PRMT1 asymmetrically residues.Lung cancer cells were cultured...
The authors investigated whether coexpression and localization of E-cadherin (E-cad) epidermal growth factor receptor (EGFR) had predictive and/or prognostic correlations with lymph node metastasis survival in patients squamous cell carcinoma the head neck (SCCHN).Immunohistochemistry (IHC) archival tissue was performed to measure expression EGFR E-cad surgical specimens SCCHN (n = 143) that included primary tumors (PTs) positive nodes (Tu+Met) their paired metastases (LnMet), PTs negative...
Background The molecular basis and characteristics of familial non-medullary thyroid cancer are poorly understood. In this study, we performed microRNA (miRNA) profiling sporadic papillary tumor samples. Methodology/Principal Findings Genome wide miRNA was performed. Differentially expressed miRNAs were validated by quantitative RT-PCR. Ectopic expression miR-886-3p in lines to identify pathways targeted the miRNA, as well as, determine its effect on cell biology. We found four...
With alkali lignin and PVA as the primary materials, glutaraldehyde cross-linker, glycerin plasticizer, lignin/PVA cross-linking reaction film was prepared by casting. The process conditions were evaluated one at a time for different variables. Mechanical properties of composite tested. performance analysed XRD, TG, SEM, FT-IR. results showed that when mass ratio 1/5, content 1.67%, glycerol 7.1% (w/w) dry matter, respectively, had satisfactory mechanical properties. Under best conditions,...