A5101980902- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Metabolomics and Mass Spectrometry Studies
- Neonatal Respiratory Health Research
- Sphingolipid Metabolism and Signaling
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- Cystic Fibrosis Research Advances
- Eosinophilic Esophagitis
- COVID-19 and Mental Health
- COVID-19 and healthcare impacts
- Pregnancy and Medication Impact
- Sepsis Diagnosis and Treatment
- Nursing Diagnosis and Documentation
- SARS-CoV-2 and COVID-19 Research
- Health and Wellbeing Research
- Medical Imaging and Pathology Studies
- School Health and Nursing Education
- High Altitude and Hypoxia
- Mast cells and histamine
- Nutrition and Health in Aging
Peking University
2015-2025
Peking University Third Hospital
2015-2025
Ningbo Product Quality Supervision and Inspection Institute
2025
National Health Research Institutes
2011
This retrospective study was designed to investigate the correlation between a novel immunosubtyping method for hepatocellular carcinoma (HCC) and biological behavior of tumor cells. A series 346 patients, who received hepatectomy at two surgical centers from January 2007 October 2010, were enrolled in this study. The expressions cytokeratin 19 (CK19), glypican 3 (GPC3), CD34 detected by immunohistochemical staining. clinical stage assessed using sixth edition tumor–node–metastasis (TNM)...
Pulmonary tuberculosis (PTB) is a risk factor for COPD. Our previous study revealed more severe emphysema in COPD patients (mostly smokers) with prior tuberculosis. However, the mechanisms of interactions between cigarette smoke (CS) and mycobacterium (Mtb) are unknown. In this study, we found that frequencies both M1 M2 macrophages, levels MMP9 MMP12 bronchoalveolar lavage were increased PTB smoking. Between-group analysis showed frequency macrophages was higher non-smoker while smokers...
Acrolein (ACR) present in vivo and vitro can damage proteins DNA, linking it to various chronic diseases. In this paper, ergothioneine (EGT), abundant edible mushrooms, has been studied for its ability trap ACR reaction pathway with at high temperatures using ultraperformance liquid chromatography–mass spectrometry (UPLC–MS/MS). We synthesized the adducts (EGT-ACR-1 EGT-ACR-2), elucidating their structure site through HRMS nuclear magnetic resonance. Subsequently, we proved synergistic...
Ambient ozone (O3) has been associated with asthma symptoms and exacerbations. The impairment of small airway function leads to worse control, more frequent exacerbations increased bronchial hyperresponsiveness in patients. However, the impact O3 on remains underexplored. Our longitudinal observational study enrolled 312 adult patients collected a total 399 lung records. We applied linear mixed-effects model analyze associations between ambient exposure at different lag days (from lag0 lag7)...
Studies have shown that glycerophospholipids are involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study adopted targeted metabolomic analysis to investigate changes serum acute exacerbation (AECOPD) and their differential expression patients with different inflammatory subtypes. Patients AECOPD admitted between January 2015 December 2017 were enrolled, clinical data collected. The patients’ gender, age, body mass index, lung function recorded. Routine blood...
Skeletal muscle dysfunction is an important comorbidity in patients with chronic obstructive pulmonary disease (COPD), and associated poor quality of life reduced survival, but the mechanisms involved remain elusive. Ferroptosis a newly discovered type cell death resulting from iron-dependent lipid peroxide accumulation. The purpose this study was to examine whether ferroptosis COPD-associated skeletal dysfunction.A mouse model COPD established after 24 weeks cigarette smoke (CS) exposure,...
Background: Social distancing and restriction measures during the COVID-19 epidemic may have impacts on medication availability healthcare utilization for COPD patients, thereby affect standard disease management. We aimed to investigate change of respiratory symptoms, pharmacological treatment patients in Beijing, China. Methods: conducted a single-center, cross-sectional survey performed at Peking University Third Hospital recruited with who were interviewed by phone call. Clinical data,...
Abstract Background Chronic obstructive pulmonary disease (COPD) is one of the most prevalent diseases worldwide. Episodes acute exacerbations COPD (AECOPD) are associated with severity and progression. Although substantial progress has been made in understanding dynamics AECOPD, little known about sputum microbiome AECOPD Chinese population. Methods In this study, we characterized microbiomes from specimens collected healthy controls ( n = 10), stable 4), 36), recovery 18) stages by...
Skeletal muscle dysfunction is an important extrapulmonary comorbidity of chronic obstructive pulmonary disease (COPD). Muscle-derived cytokines (myokines) play roles in skeletal growth and function, but their contributions to COPD have not been fully understood. In the current study, by using a well-established mouse model with dysfunction, we found that expressions Fndc5 (fibronectin type III domain-containing protein 5, precursor irisin) peroxisome proliferator-activated receptor-γ...
Our study aimed to investigate whether serum total IgE and blood eosinophils were associated with radiological features of bronchiectasis in a Chinese cohort.We retrospectively enrolled patients who visited Peking University Third Hospital from Jan 1st, 2012 Oct 7th, 2021. The clinical, laboratory chest CT characteristics analyzed association level eosinophil count.A 125 enrolled, 50.4% (63/125) female, mean age 62.4 ± 14.1 years. median count 47.7 (19.8, 123.0) KU/L 140 (90, 230) cells/µl,...
Aging is a critical risk factor for unfavorable clinical outcomes among COVID-19 patients and may impact vaccine efficacy. However, whether the senescence of T cells associated with severe outcome in elderly individuals unclear. Using flow cytometry, we analyzed frequency senescent (Tsens) peripheral blood from 100 hospitalized compared differences between those mild/moderate severe/critical illness. We also assessed correlations percentage Tsens quantity quality spike-specific antibodies by...
ABSTRACT Mounting evidence has revealed the association between gut microbiota and both chronic obstructive pulmonary disease (COPD) asthma; however, causal specific phenotypes remains to be determined. This study employed bidirectional two-sample Mendelian randomization (MR) analyses investigate potential relationship these conditions. The research utilized genome-wide (GWAS) data from MiBioGen consortium for integrative epidemiology unit (IEU) Open GWAS Four MR analysis methods were...
To demonstrate the effectiveness of health-promoting school framework to promoting healthy eating behaviours and nutrition knowledge among Chinese middle students, their parents staff. Three schools were randomly selected from 15 rural schools, then assigned either (i) using HPS (HPS school), (ii) with improved health education only (HE school) or (iii) received no intervention (control school). Nutrition measured at baseline 3-month after interventions, same instrument. Students in had...
Bacterial infection is a major cause of acute exacerbations chronic obstructive pulmonary disease (AECOPD), which are associated with significantly increased airway and systemic inflammation. However, the relationship among bacteriology, resolution inflammation clinical outcomes largely unknown. In this study, we recruited consecutive patients hospitalized for AECOPD purulent sputum. We measured levels, COPD assessment test (CAT) score adverse between without potentially pathogenic...
Abstract Sphingolipids metabolism is an important cell process and plays critical roles in asthma. However, the involvement of sphingolipids pathogenesis asthma its subtypes unknown. The present study aimed to determine role subtypes. Clinical data from 51 patients 9 healthy individuals were collected serum samples performed analyze levels by liquid chromatography-mass spectrometry-based targeted metabolomics. Results showed that sphingomyelin (SM) including SM34:2, SM38:1, SM40:1...
OBJECTIVE: Frequent readmissions for acute exacerbations of COPD (AECOPD) are an independent risk factor increased mortality and use health-care resources. Disease severity C-reactive protein (CRP) level validated predictors long-term prognosis in such patients. This study investigated the utility combining serum CRP with Global Initiative Chronic Obstructive Lung (GOLD) exacerbation classification predicting readmission AECOPD. METHODS: was a prospective observational consecutive patients...
The association between increases in both systemic and airway inflammation acute exacerbation of COPD (AECOPD) has been reported by many studies. However, relatively little is known about the dynamics resolution their correlations with improvement clinical indices during treatment. In this study, a total 93 consecutively hospitalized patients AECOPD were recruited. Sputum serum inflammatory markers measured on day admission before treatment (day 0), 4, 7 14 as well 8 weeks after discharge....