A5101671354- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Coronary Interventions and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Acute Myocardial Infarction Research
- Ferroptosis and cancer prognosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Angiogenesis and VEGF in Cancer
- Mitochondrial Function and Pathology
- COVID-19 Clinical Research Studies
- Inflammation biomarkers and pathways
- Lipoproteins and Cardiovascular Health
- Neuroscience of respiration and sleep
- Biotin and Related Studies
- Phytochemistry and biological activity of medicinal plants
- Receptor Mechanisms and Signaling
- Autoimmune and Inflammatory Disorders Research
- Apelin-related biomedical research
- Pleural and Pulmonary Diseases
- S100 Proteins and Annexins
- Cardiovascular Disease and Adiposity
- Advanced Glycation End Products research
Guangxi Medical University
2025
University of California, San Francisco
2023-2024
Tianjin University of Traditional Chinese Medicine
2024
Pudong Medical Center
2024
Second Affiliated Hospital of Guangzhou Medical University
2024
Guangdong Medical College
2024
Guangzhou Medical University
2024
Second Xiangya Hospital of Central South University
2024
Central South University
2024
First Affiliated Hospital of Guangzhou Medical University
2024
Diabetes increases the risk and severity of atherosclerosis. Adropin, a metabolic homeostasis-related protein, has been implicated in maintenance homeostasis. We examined relationship between serum adropin level angiographic coronary atherosclerosis diabetic non-diabetic patients.A total 392 patients with suspected artery disease, who underwent angiography, were assigned into type 2 groups also classified four according to quartiles level. Venous samples collected for measurement by...
Several epidemiologic studies have reported that cyclooxygenase (COX) inhibitors prevent/delay the onset of Alzheimer's disease (AD). Recent experimental suggest these compounds can also diminish amyloid-beta (Abeta) neuropathology in rodent models AD. To explore relationship COX expression to Abeta neuropathology, we crossed mice expressing both mutant amyloid precursor protein [K670N/M671L (APP(swe)] and PS1 (A246E) with human COX-2 selectively neurons. We show here APP(swe)/PS1/COX-2...
<b>Objective: </b> To conduct a large population-based survey on multiple sclerosis (MS) prevalence in Shanghai, China. <b>Methods: We established network of physicians, mainly neurologists, for identifying prevalent patients with MS and systematically checked inpatient registers at each hospital the study area diagnosis MS, neuromyelitis optica, or other demyelinating disorders. was validated by senior neurologists according to McDonald criteria. <b>Results: In total, 123 from population,...
The present study was designed to examine whether astaxanthin (ASX, 3,3-dihydroxybeta, beta-carotene-4,4-dione, CAS 472-61-7), a dietary antioxidant carotenoid that is naturally in algae, crustaceans, and fish, has protective effect on endothelial dysfunction of aortas diabetic rats the possible molecular mechanism involved. Male Wistar were randomly divided into four groups: control rats, treated with ASX (10 mg/kg/d), ASX. Type 1 diabetes induced by single intraperitoneal injection...
Sepsis is a life-threatening infectious disease in which an immune inflammatory response triggered. The potential effect of ferroptosis-related genes (FRGs) inflammation sepsis remained unclear. We focused on identifying and validating core FRGs their association with infiltration blood from currently all patients sepsis. All current raw data septic were obtained Gene Expression Omnibus. After removing the batch merging into complete dataset obtaining Diferentially expressed (DEGs). Common...
Bartonella spp. are emerging, potentially zoonotic pathogens that most often transmitted by arthropod vectors or animal bites and scratches. However, the vector species involved in transmission of human bartonellosis remain poorly understood. This study investigated presence Triatoma rubrofasciata from Guangxi Hainan provinces China, evaluating its potential role as a for disease. was identified T. samples through PCR amplification sequencing ITS, gltA, rpoB genes. The survival duration...
Abstract Background Angiographic coronary lesion complexity has been reported to predict plaque vulnerability. It is important develop a noninvasive blood biomarker for accurate prognostication of angiographically complex lesions in patients with artery disease (CAD). Hypothesis Serum soluble lectin‐like oxidized low‐density lipoprotein receptor‐1 (sLOX‐1) levels may be correlated CAD. Methods We measured serum sLOX‐1 180 consecutive undergoing angiography the evaluation Coronary were...
Background Endothelial dysfunction plays an important role in the pathophysiology of coronary artery disease (CAD). Previous studies suggested that human endothelial cell-specific molecule-1 (endocan) may be a novel marker. This study aims to investigate relationship between serum endocan level and presence severity CAD patients with hypertension. Methods A total 190 eligible hypertension were enrolled this study. Serum was measured by enzyme-linked immunosorbent assay. The evaluated...
This study highlights the importance of asprosin in regulation appetite. peptide hormone was first described by Romere et al. 2016 (1), who reported 2 patients with neonatal progeroid syndrome (NPS) due to truncating heterozygous mutations fibrillin-gene (FBN1). The FBN1 gene encodes profibrillin which is cleaved protease furin, yielding mature fibrillin and a C-terminal cleavage product, asprosin. mutation led 50% reduced concentration serum, associated extreme leanness. Usually, partial or...
Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) may be a potential biomarker of coronary artery disease (CAD) and stroke. We aimed to investigate the association prognostic value elevated sLOX-1 concentrations with regard long-term major adverse cardiovascular cerebrovascular events (MACCEs) in patients CAD undergoing primary percutaneous intervention (PCI). A total 1011 were enrolled. Serum detected by enzyme-linked immunosorbent assay (ELISA). Patients followed for...
We sought to assess whether serum endocan concentration is correlated with coronary slow flow (CSF). measured in 93 patients CSF and 206 controls. Serum was by enzyme-linked immunosorbent assay (ELISA). The presence of assessed thrombolysis myocardial infarction (TIMI) frame count (TFC) method. demonstrated that significantly higher (n = 93) than controls 206) (1.03 [range 0.63–1.33] vs. 0.80 0.52–1.09] ng/mL, p 0.002). Multivariate logistic regression analysis revealed independently...
Adropin is a peptide hormone expressed in coronary artery endothelial cells, which plays potential protective role. We sought to assess whether serum adropin levels are correlated with the slow flow phenomenon (CSFP).We enrolled 82 patients angiographically confirmed CSFP and 184 age-matched controls. Serum were measured by enzyme-linked immunosorbent assay (ELISA), rate was assessed using thrombolysis myocardial infarction (TIMI) frame count (TFC). defined as corrected TIMI-TFC greater than...
Abstract Introduction No-reflow phenomenon (NRP) is one of the complications that mostly occur during percutaneous coronary intervention (PCI). In this study, we comprehensively examined relationship between model for end-stage liver disease-XI (MELD-XI) score and NRP. Moreover, discussed whether MELD-XI could be considered as an accurate risk assessment patients with ST-segment elevation myocardial infarction (STEMI) who are candidates PCI. Methods This retrospective study involved 693...
This study aimed to evaluate the utility of virtual histology intravascular ultrasound (VH-IVUS) for recognizing vulnerable plaque compared histological pathological analysis. Four-month-old New Zealand rabbits ( n = 16) were randomly divided into two groups: one fed a high-fat diet and subjected balloon injury (experimental, 10) alone (control, 6). Blood lipid profiles overnight-fasted measured at week 2 (beginning study) 12 (end study). At 12, experimental group underwent IVUS under...
<title>Abstract</title> Evidence for the treatment of patients with mild-to-moderate chronic obstructive pulmonary disease (COPD) is limited. The efficacy N-acetylcysteine (an antioxidant and mucolytic agent) COPD uncertain. In this multicentre, randomised, double-blind, placebo-controlled trial, we randomly assigned 968 to (600mg, twice daily) or matched placebo two years. Eligible participants were 40–80 years age had (forced expiratory volume in 1 second [FEV<sub>1</sub>] forced vital...
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Abstract Disorders of lung development may result in secondary pulmonary arterial hypertension (PAH), a complex condition marked by elevated pressure and impaired function the right ventricle. Yes-associated protein (YAP), pivotal mediator Hippo pathway, has gained growing recognition as vital component signaling network that regulates cell behavior during development. However, roles Yap both alveolar vascularization well its involvement pathogenesis PAH remain unknown. By investigating mice...
Abstract Background The outbreak of the novel coronavirus SARSCoV-2 (coronavirus disease 2019; COVID-19) has spread to most countries in world. tight relationship plasma lipids and COVID-19 pneumonia (NCIP-19) not been well invested. To observe lipid profiles their alterations hospitalized patients with evaluated prognostic value for length hospital stay (LOS). Methods 248 NCIP-19 cases aged 18 years or older were enrolled this study. Serum lipids, including triglycerides (TG), total...
Objective To explore the effects of adjuvant chemotherapy combined with Kang'ai injection on expression serum VEGF in patients advanced non-small cell lung cancer.Methods Forty-six cancer were randomly divided equally into two groups.Patients experimental group treated gemcitabine and cisplatin regimen(GP) injection,while control just GP regimen chemotherapy.The levels vascular endothelial growth factor(sVEGF) measured by ELISA before after treatment,respectively.Results The sVEGF all NSCLC...