A5078139435- Inflammasome and immune disorders
- Healthcare and Venom Research
- Cardiac Ischemia and Reperfusion
- Eicosanoids and Hypertension Pharmacology
- Corneal Surgery and Treatments
- Immunotherapy and Immune Responses
- Rheumatoid Arthritis Research and Therapies
- Ocular Surface and Contact Lens
- Pharmacological Effects of Natural Compounds
- Adipokines, Inflammation, and Metabolic Diseases
- Hernia repair and management
- Cardiac Valve Diseases and Treatments
- Adipose Tissue and Metabolism
- Pregnancy and preeclampsia studies
- Renin-Angiotensin System Studies
- Heart Rate Variability and Autonomic Control
- Cardiac, Anesthesia and Surgical Outcomes
- Traditional Chinese Medicine Studies
- Immune Cell Function and Interaction
- Hormonal Regulation and Hypertension
- Peroxisome Proliferator-Activated Receptors
- Supramolecular Self-Assembly in Materials
- Boron Compounds in Chemistry
- ATP Synthase and ATPases Research
- Cell Adhesion Molecules Research
Chinese PLA General Hospital
2016-2024
Xi'an Jiaotong University
2010-2021
Dalian Medical University
2021
Nanjing Maternity and Child Health Care Hospital
2020
Nanjing Medical University
2020
First Affiliated Hospital of Xi'an Jiaotong University
2008-2020
Wuhan University
2018-2020
Center for Human Reproduction
2020
Zhongnan Hospital of Wuhan University
2020
Zunyi Medical University
2020
Inhibitors of apoptosis and excitotoxic cell death reduce brain damage after transient permanent middle cerebral artery occlusion. We compared the neuroprotective effects two caspase family inhibitors with N-methyl-d-aspartate receptor antagonist (+)-MK-801 hydrogen maleate (MK-801) in a newly characterized cycloheximidesensitive murine model occlusion (30 minutes) which apoptotic is prominent. Ischemic infarction, undetected by 2,3,5-triphenyltetrazolium chloride staining at 24-hour...
Ischemia reperfusion (I/R)-induced acute kidney injury (AKI) is a common and serious condition. Irisin, an exercise-induced hormone, improves mitochondrial function reduces reactive oxygen species (ROS) production. Glutathione peroxidase 4 (GPX4) key regulator of ferroptosis its inactivation aggravates renal I/R by inducing ROS However, the effect irisin on GPX4 I/R-induced AKI still unknown. To study this, male adult mice were subjected to occluding bilateral hilum for 30 min, which was...
Native C-reactive protein (nCRP) is a non-specific marker of inflammation being claimed as bystander in several chronic disorders. Accumulating evidence indicates that nCRP dissociates to and acts primarily the monomeric conformation (mCRP) at inflammatory loci. This suggests mCRP may be superior disease with improved specificity clear causality underlying pathogenesis. However, lack feasible assay quantify clinical samples precludes assessment suggestion. Here we report development sandwich...
The present study was designed to examine whether astaxanthin (ASX, 3,3-dihydroxybeta, beta-carotene-4,4-dione, CAS 472-61-7), a dietary antioxidant carotenoid that is naturally in algae, crustaceans, and fish, has protective effect on endothelial dysfunction of aortas diabetic rats the possible molecular mechanism involved. Male Wistar were randomly divided into four groups: control rats, treated with ASX (10 mg/kg/d), ASX. Type 1 diabetes induced by single intraperitoneal injection...
Human C-reactive protein (CRP) is a serum-soluble pattern recognition receptor that serves as marker of inflammation and directly contributes to innate immunity. In this study, we show human CRP also adaptive immunity, is, native binds specifically Jurkat T cells mouse naive CD4(+) modulates their Th1 Th2 responses. vitro both exogenously added (purified) endogenously expressed (via transfection) inhibited differentiation augmented cells. vivo for transgenic compared with wild-type mice,...
Previous studies have reported the pathogenic role of C-reactive protein (CRP) during diabetic kidney disease (DKD) in human CRP transgenic and Crp-/- mice. However, because humans mice inverse acute phase expression patterns serum amyloid P component, this could lead to inaccurate evaluation function with above-mentioned mouse. But different from mice, rats same pattern as human, which might avoid problem be a better choice for studies. To dispel doubt accurately define nephropathy, we...
The aim of the present study was to investigate cytotoxic activity cytokine-induced killer (CIK) cells targeted by an epidermal growth factor receptor (EGFR)/CD3 bispecific antibody (BsAb) gastric cancer cell line SGC7901. A BsAb constructed chemically cross-linking a monoclonal (McAb) against human CD3 with another McAb EGFR. An immunocytochemistry assay performed detect expression EGFR in SGC7901 cells. CIK EGFR/CD3 analyzed 51Cr release assay, Subsequently, comparison between BsAb, or/and...
Nowadays, reperfusion is still the most effective treatment for ischemic heart disease. However, cardiac therapy would lead to injury, which may have resulted from endoplasmic reticulum stress (ERS) during reperfusion. Diazoxide (DZ) a highly selective mitochondrial adenosine triphosphate-sensitive potassium channel opener. Its protective effect on I/R injury has been confirmed in many organs such as and brain. mechanism of its not fully elucidated. MicroRNAs (miRNAs) are widely involved...
Objective. Lipid peroxidation plays a critical role in burn-induced plasma leakage, and ulinastatin has been reported to reduce lipid various models. This study aims examine whether reduces fluid requirements through inhibition of swine burn model. Methods. Forty miniature were subjected 40% TBSA burns randomly allocated the following four groups: immediate lactated Ringer's resuscitation (ILR), LR containing (ILR/ULI), delayed (DLR), (DLR/ULI). Hemodynamic variables, net accumulation,...
Abstract Background The therapeutic role of mesenchymal stem cells (MSCs) has been widely confirmed in several animal models premature infant diseases. Micromolecule peptides have shown promise for the treatment However, potential secreted from MSCs not studied. purpose this study is to help broaden knowledge hUC-MSC secretome at peptide level through peptidomic profile analysis. Methods We used tandem mass tag (TMT) labeling technology followed by spectrometry compare preterm and term...
Aldehyde dehydrogenase 2 activity is associated with cardioprotection. Individuals carrying an East Asian variant of the ALDH2 genotype (ALDH2*2) have significantly reduced aldehyde activity. No previous studies determined effect ALDH2*2 on cardioprotective results after coronary artery bypass grafting (CABG).In total, 207 patients who underwent selective off-pump CABG were prospectively enrolled. Their baseline characteristics and clinical collected. Preoperative postoperative circulating...
This study evaluated changes in interleukin (IL)-27 levels patients with acute coronary syndrome (ACS) and their influence on Th1, Th2, Th17 cells.Serum of IL-27, IL-4, IL-17, interferon (IFN)-γ healthy subjects as well ACS, including stable angina pectoris (SA), unstable (UA), myocardial infarction (AMI), were determined using an enzyme-linked immunosorbent assay. The proportions cells among peripheral blood mononuclear (PBMCs), measured flow cytometry, after incubation phorbol myristate...
• The effects of astaxanthin on gout were observed in a randomized controlled trial. Astaxanthin has lowering effect the index arthritis. combined with western medicine may be an alternative method for gout. Contributing rationale as dietary supplement to assist Gout is form arthritis caused by hyperuricemia that can significantly affect patient's quality life. Here, we investigated therapeutic astaxanthin, carotenoid strong anti-inflammatory and antioxidant properties, results animal...
Experimental autoimmune encephalomyelitis (EAE) is a classical murine model for Multiple Sclerosis (MS), human disease characterized by Th1 and Th17 responses. Numerous studies have reported that C-reactive protein (CRP) mitigates EAE severity, but on the relevant pathologic mechanisms are insufficient. Our previous study found CRP suppresses response directly receptor binding naïve T cells; however, we did not observe effect at time; thus it remains unclear whether could regulate response....
This paper presents a set of quantum Reed-Muller codes which are typically 100 times more effective than existing codes.
Enhanced plasmid
Aortic valve replacement (AVR) is a critical procedure for patients with aortic diseases. This study compares the effectiveness of three minimally-invasive surgical approaches AVR: totally thoracoscopic (TT), right anterior mini-thoracotomy, and upper mini-sternotomy. We analyzed retrospective data from 130 who underwent one these surgeries, focusing on various factors such as duration hospital stay, operation time, times cardiopulmonary bypass cross-clamping, postoperative complications,...
Abstract Amyloid‐β peptides (Aβs) are generated in a membrane‐embedded state by sequential processing of amyloid precursor protein (APP). Although shedding Aβ is essential for its secretion and neurotoxicity, the mechanism behind regulation not fully elucidated. Thus, we devised Langmuir film balance‐based assay to uncover this mechanism. We found that was enhanced under acidic pH conditions lipid compositions resembling raft microdomains, which directly related microenvironment generation....