A5101928980- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Congenital heart defects research
- Prenatal Screening and Diagnostics
- Congenital Heart Disease Studies
- Neural dynamics and brain function
- Psychosomatic Disorders and Their Treatments
- RNA modifications and cancer
- Coronary Artery Anomalies
- Genomic variations and chromosomal abnormalities
- Congenital Ear and Nasal Anomalies
- Advanced Neuroimaging Techniques and Applications
- Tracheal and airway disorders
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- RNA and protein synthesis mechanisms
- Parvovirus B19 Infection Studies
- Suicide and Self-Harm Studies
- Neural and Behavioral Psychology Studies
- Ectopic Pregnancy Diagnosis and Management
- Maternal Mental Health During Pregnancy and Postpartum
- Infant Nutrition and Health
- Mesenchymal stem cell research
- Bone fractures and treatments
Nanjing Brain Hospital
2018-2023
Nanjing Medical University
2013-2023
Nanjing Normal University
2018-2023
Nanjing Maternity and Child Health Care Hospital
2013-2023
Beijing Children’s Hospital
2015
Capital Medical University
2015
Abstract Background Many studies have found that the hippocampus plays a very important role in major depressive disorder (MDD). The can be divided into three subfields: cornu ammonis (CA), dentate gyrus (DG) and subiculum. Each subfield of has unique function are differentially associated with pathological mechanisms MDD. However, no research exists to describe resting state functional connectivity each hippocampal Methods Fifty-five patients MDD 25 healthy controls (HCs) matched for...
The aim of the current study was to localize epileptic focus and characterize its causal relation with other brain regions, understand cognitive deficits in children benign childhood epilepsy centrotemporal spikes (BECTS). Resting-state functional magnetic resonance imaging (fMRI) performed 37 BECTS 25 matched for age, sex educational achievement. We identified potential epileptogenic zone (EZ) by comparing amplitude low frequency fluctuation (ALFF) spontaneous blood oxygenation level...
Abstract Background Generalized anxiety disorder (GAD) is closely associated with emotional dysregulation. Patients GAD tend to overreact stimuli and are impaired in regulation. Using regulation task, studies have found hypo-activation prefrontal cortex (PFC) of patients concluded inadequate top-down control. However, results remain inconsistent concerning PFC limbic area’s reactivity stimuli. What’s more, only a few aim identify how area interacts patients. The current study aims the...
Congenital heart disease (CHD) is one of the most predominant birth defects that causes infant death worldwide. The timely and successful surgical treatment CHD on newborns after delivery requires accurate detection reliable diagnosis during pregnancy. However, there are no biomarkers can serve as an early diagnostic factor for patients. tRNA-derived fragments (tRFs) have been reported to play important role in occurrence progression numerous diseases, but their roles remains...
Accumulating evidence from functional magnetic resonance imaging studies supported brain dysfunction during emotional processing in bipolar disorder (BD) and major depressive (MDD). However, child adolescent BD MDD could display different activation patterns, which have not been fully understood. This study aimed to investigate common distinct patterns of pediatric (PBD) (p-MDD) emotion using meta-analytic approaches. Literature search identified 25 studies, contrasting 252 PBD patients, 253...
This study assessed the growth trends and reference ranges of ultrasound parameters, fetal abdominal subcutaneous tissue thickness (ASTT) subscapular (SSTT), in last two trimesters normal pregnancy a Chinese population. We recruited 744 healthy women with singleton pregnancies. The ASTT SSTT were evaluated at different times between 21 36 weeks gestation. correlations these parameters gestational using linear regression analysis. Both increased gestation, both showed strong correlation...
Congenital heart defects (CHD) represent one of the most common birth defects. This study aimed to evaluate value multiplex ligation-dependent probe amplification (MLPA) as a tool detect copy number variations (CNVs) 22q11 in fetuses with CHD.A large cohort 225 CHD was screened by fetal echocardiography. Once chromosome abnormalities 30 were out conventional G-banding analysis, CNVs remaining 195 determined MLPA for prenatal genetic counseling. In normal karyotype, 11 cases had pathological...
BACKGROUND The present study aimed to investigate the potential effects of propofol on ankle fracture healing in children and underlying molecular mechanisms. MATERIAL AND METHODS We first detected levels inflammatory cytokines from peripheral blood with or without using quantitative real-time polymerase chain reaction (qRT-PCR) ELISA assay. Then, response MG-63 cells were investigated. pre-treated then stimulated 1 μM bradykinin (BK). productions determined by qRT-PCR Western blot...
Bankground The phenotype of duplication 1q21.1 region is variable, ranging from macrocephaly, autism spectrum disorder, congenital anomalies, to a normal phenotype. Few cases have been reported in the literature regarding prenatal diagnosis syndrome. current study presents syndrome three fetuses with ultrasound anomalies. Case presentation Three unrelated families were included study. examination showed nasal bone loss Fetus 1 and 3, as well duodenal atresia 2. Chromosomal microarray...
Abstract Background The therapeutic role of mesenchymal stem cells (MSCs) has been widely confirmed in several animal models premature infant diseases. Micromolecule peptides have shown promise for the treatment However, potential secreted from MSCs not studied. purpose this study is to help broaden knowledge hUC-MSC secretome at peptide level through peptidomic profile analysis. Methods We used tandem mass tag (TMT) labeling technology followed by spectrometry compare preterm and term...
Tetralogy of fallot (TOF) is one the most prevalent types congenital heart diseases. As a category bioactive molecules, peptides have been proved to participate in various biological processes. However, role endogenous pathogenesis TOF has not studied. In this study, we performed comparative peptidomic profile fetal and control group for first time by liquid chromatography-tandem mass spectrometry. Our data demonstrated that total 201 derived from 176 precursor proteins were differentially...
Objective This study aimed to test the hypothesis that relationship between glutamic acid decarboxylase (GAD) 1 gene methylation and severity of clinical symptoms panic disorder (PD) is mediated by effect GAD1 on gray matter volume (GMV) GMV PD. Methods Panic ( n = 24) patients were recruited consecutively from Affiliated Brain Hospital Nanjing Medical University through outpatient public advertising, eligible healthy controls (HCs) 22) advertising. We compared in PD HCs estimate...
Abstract Abnormal development of embryonic conus arteriosus could lead to conotruncal defects in fetal heart, and increase the incidence congenital heart disease. Tetralogy Fallot (TOF) is one most common forms It may be helpful for us solve this clinical problem through exploring molecular mechanisms Proteomics has attracted much attention understanding human diseases during past decades. However, there still little information about relationship between protein expression pattern TOF. In...