A5070973930- Infant Nutrition and Health
- Mesenchymal stem cell research
- Protein Hydrolysis and Bioactive Peptides
- Adipose Tissue and Metabolism
- Neonatal Respiratory Health Research
- Adipokines, Inflammation, and Metabolic Diseases
- Renal Diseases and Glomerulopathies
- Cancer-related molecular mechanisms research
- Advancements in Transdermal Drug Delivery
- Circular RNAs in diseases
- Antimicrobial Peptides and Activities
- melanin and skin pigmentation
- Vasculitis and related conditions
- Colorectal Cancer Screening and Detection
- MicroRNA in disease regulation
- Anesthesia and Sedative Agents
- Systemic Lupus Erythematosus Research
- Dermatology and Skin Diseases
- Biochemical Analysis and Sensing Techniques
- Gastric Cancer Management and Outcomes
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Gastroesophageal reflux and treatments
- RNA regulation and disease
Nanjing Medical University
2013-2025
Wenzhou Medical University
2025
Second Xiangya Hospital of Central South University
2022-2024
Central South University
2022-2024
Hubei University of Chinese Medicine
2024
Nanjing Maternity and Child Health Care Hospital
2016-2023
Changzhou No.2 People's Hospital
2015-2023
University of Rhode Island
2017-2021
Women's Hospital
2020
Xingtai People's Hospital
2019
Allostery is the most direct, rapid and efficient way of regulating protein function, ranging from control metabolic mechanisms to signal-transduction pathways. However, an enormous amount unsystematic allostery information has deterred scientists who could benefit this field. Here, we present AlloSteric Database (ASD), first online database that provides a central resource for display, search analysis structure, function related annotation allosteric molecules. Currently, ASD contains 336...
Human breast milk has been shown to prevent necrotizing enterocolitis (NEC). Although exosomes have identified in milk, their function and components not fully addressed. This study is conducted elucidate the differences peptidomic complexities between preterm term exosomes.Breast samples are collected from healthy lactating mothers who delivered infants. Exosomes separated quantified. The protective effects of purified against NEC investigated both vitro vivo. analyzed by iTRAQ LC-MS/MS...
Abstract Protein/subunit vaccines often require external adjuvants to induce protective immunity. Due the safety concern of chemical adjuvants, physical were recently explored boost vaccination. Physical use energies rather than chemicals stimulate tissue stress and endogenous danger signal release Here we present potency non-invasive radiofrequency treatment intradermal vaccination in murine models. We show can increase protein antigen-induced humoral cellular immune responses with adjuvant...
Abstract Gestational Diabetes Mellitus (GDM) is the most frequent complication during pregnancy. Pharmacological interventions, such as peptide drugs that focused on improving insulin sensitivity might be promising in prevention and treatment of GDM. In this study, we aimed to investigate role mechanism a novel peptide, named AGDMP1 (Anti‐GDM 1), which previously identified lower serum GDM patients using mass spectrometry, adipose resistance We found had high affinity for tissues vivo ....
Gastrointestinal endoscopy with sedation is frequently complicated by hypoxemia. Nasal cannulas have limitations in eliminating We hypothesized that the combination of nasal clips and would improve inspired oxygen concentrations prevent hypoxemia compared use alone. A total 600 adult patients were randomly assigned to receive supplemental through single-lumen or cannulas. The primary outcome was incidence Additionally, subclinical respiratory depression severe hypoxemia, duration lowest SpO2...
Brown adipose tissue (BAT) oxidizes fatty acids for thermogenesis and could therefore be considered as part of a new strategy in combating obesity associated metabolic diseases. It is well established that aging accompanied by decline brown adipocyte regenerative capacity. How contributes to this loss poorly understood. Here, we identify long noncoding RNA, uc.417, which transcribed from an ultraconserved region rodents. Expression uc.417 increases with age. Ectopic expression impairs...
MicroRNAs (miRNAs), a class of small non-coding RNAs, mediate gene expression by either cleaving target mRNAs or inhibiting their translation. They have key roles in the tumorigenesis several cancers, including non-small cell lung cancer (NSCLC). The aim this study was to investigate clinical significance miR-638 evaluation NSCLC patient prognosis response chemotherapy. First, we detected levels vitro culture supernatants line SPC-A1 treated with cisplatin, as well apoptosis rates SPC-A1....
Isoliquiritigenin (ISL), a flavonoid component from the hydrolysis products of licorice root. It has been reported that ISL inhibited melanogenesis by suppressing tyrosinase activity in human melanocytes. Recently, was found to induce melanin degradation epidermal keratinocytes. However, role pigmentation is not fully understood. In current study, we aimed investigate effects on pigmentation, and further explored underlying mechanism. Our results suggested suppressed basal α-MSH-, ACTH-...
A novel endogenous peptide CAMP<sub>211-225</sub>up-regulated in preterm milk specifically kills<italic>E. coli</italic>and<italic>Y. enterocolitica</italic>through a membrane-disrupting mechanism.
Tumor survival is significantly correlated with the immune response of patients. IFNG plays an important role in tumor host and decreased expression often observed lung cancer. Studies have shown that CpG island hypermethylation a critical transcriptional silencing gene expression. However, there limited understanding regarding molecular mechanisms altered methylation, whether microenvironment has any effect on DNA methylation production. In current study, we demonstrate plasma...
Abstract Background Henoch-Schönlein purpura nephritis (HSPN) is the principal cause of morbidity and mortality in children with (HSP). However, criteria for risk assessment currently used not satisfactory. The urine proteome may provide important clues to indicate development HSPN. Methods Here, we detected compared patients HSPN healthy controls by liquid chromatography-tandem mass spectrometry (LC–MS/MS) data-independent acquisition (DIA) mode. differentially expressed proteins were...
Vaccine delivery technologies are mainly designed to minimally invasively deliver vaccines target tissues with little or no adjuvant effects. This study presents a prototype laser-based powder (LPD) inherent effects for more immunogenic vaccination without incorporation of external adjuvants. LPD takes advantage aesthetic ablative fractional laser generate skin microchannels support high-efficient vaccine and at the same time creates photothermal stress in microchannel-surrounding boost...