A5003017663- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Chronic Kidney Disease and Diabetes
- MicroRNA in disease regulation
- Nephrotoxicity and Medicinal Plants
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Circular RNAs in diseases
- Platelet Disorders and Treatments
- Cancer-related molecular mechanisms research
- Cell Adhesion Molecules Research
- Reproductive System and Pregnancy
- Blood groups and transfusion
- Complement system in diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Systemic Lupus Erythematosus Research
- Adipose Tissue and Metabolism
- Adolescent and Pediatric Healthcare
- Pregnancy and Medication Impact
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mast cells and histamine
- Metabolism and Genetic Disorders
- Immunodeficiency and Autoimmune Disorders
- Renal and related cancers
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
Nanjing University
2014-2024
Nanjing General Hospital of Nanjing Military Command
2015-2024
Southeast University
2022-2024
Southern Medical University
2019-2023
Nanjing Medical University
2019-2023
Jinling Institute of Technology
2010-2023
Guangzhou Medical University
2023
81th Hospital of PLA
2020
Sichuan University
2014
West China Hospital of Sichuan University
2014
MicroRNAs (miRNAs) are present in body fluids and may have the potential to serve as disease biomarkers. This study explored clinical value of miRNAs serum urine biomarkers for idiopathic childhood nephrotic syndrome (NS).We obtained samples from 159 NS children (24 steroid resistant 135 sensitive), 109 age/sex-matched healthy controls 44 with other kidney diseases. Serum were analyzed TaqMan Low Density Array then validated a quantitative reverse-transcription PCR assay 126 individual...
The Oxford classification of IgA nephropathy (IgAN) provides a useful tool for prediction renal prognosis. However, the application this in children with IgAN needs validation different patient populations.A total 218 from 7 centers China were enrolled. inclusion criteria was similar to original study.There 98 patients (45%) mesangial proliferation (M1), 51 (23%) endocapillary (E1), 136 (62%) segmental sclerosis/adhesion lesion (S1), 13 (6%) moderate tubulointerstitial fibrosis (T1 26-50%...
Abstract Background Previously, several studies have indicated that pediatric IgA nephropathy (IgAN) might be different from adult IgAN, and treatment strategies also between IgAN IgAN. Methods We analyzed two prospective cohorts established by nephrologists, respectively. A comprehensive analysis was performed investigating the difference in clinical pathological characteristics, treatment, prognosis children adults with Results total of 1015 1911 were eligible for analysis. More frequent...
<title>Abstract</title> <bold>Background</bold>: The efficacy of glucocorticoid (GC) in the management immunoglobulin A nephropathy (IgAN) remains highly controversial. study was conducted to analyze and kidney outcomes GC treatment pediatric IgAN. <bold>Methods:</bold> Using follow-up data children with chronic disease from Department Pediatrics at Jinling Hospital between January 2000 December 2020, we selected primary IgAN who were ≤18 years old, confirmed by renal biopsy, had undergone...
MicroRNAs (miRNAs, miRs) are involved in most physiological, developmental, and pathological processes. miR-192 miR-205 expressed preferentially the renal cortex closely relevant to cell biology. In present study, we aim measure serum levels of their correlation with clinicopathological data patients primary focal segmental glomerulosclerosis (FSGS) minimal change disease (MCD).Fifty-six (35 male, 21 female) idiopathic nephrotic syndrome (FSGS 30, MCD 26) 20 healthy controls were enrolled...
Abstract Background Henoch-Schönlein purpura nephritis (HSPN) is the principal cause of morbidity and mortality in children with (HSP). However, criteria for risk assessment currently used not satisfactory. The urine proteome may provide important clues to indicate development HSPN. Methods Here, we detected compared patients HSPN healthy controls by liquid chromatography-tandem mass spectrometry (LC–MS/MS) data-independent acquisition (DIA) mode. differentially expressed proteins were...
Circular RNAs (circRNAs) have been studied in a number of diseases. However, the roles circRNAs hypoxic‑ischemic brain damage (HIBD) remains unknown. In present study, high throughput sequencing was used to profile altered HIBD rats. A total 66 were identified be differentially expressed (fold‑change >2 and P‑value <0.05) rats compared with control group, including 20 upregulated 46 downregulated circRNAs. Gene ontology Kyoto Encyclopedia Genes Genomes pathway analysis indicated that...
Abstract Background The 2016 Oxford Classification’s MEST-C scoring system predicts outcomes in adults with IgA nephropathy (IgAN), but it lacks tremendous cohort validation children IgAN China. We sought to verify whether the classification could be used predict renal outcome of IgAN. Methods In this retrospective study, 1243 Chinese who underwent biopsy Jinling Hospital were enregistered from 2000 2017. combined endpoint was defined as either a ≥ 50% reduction estimated glomerular...
MicroRNA‑106b (miR‑106b) is reported to correlate closely with skeletal muscle insulin resistance. In the current study effect of miR‑106b on palmitic acid (PA)‑induced mitochondrial dysfunction and resistance was investigated in C2C12 myotubes via silencing miR‑106b. MiR‑106b expression increased under PA treatment, while loss function improved sensitivity by upregulating its target mitofusin‑2 (Mfn2) myocytes. Furthermore, partly morphological lesions levels mitochondial DNA intracellular...
Introduction: Henoch–Schönlein purpura nephritis (HSPN) and IgA nephropathy (IgAN) bear similarities in some aspects. The histological classification of HSPN was built on the International Study Kidney Disease Children (ISKDC) criteria, while IgAN established 2016 Oxford (MEST-C scores). purpose this paper to discuss predictive value ISKDC MEST-C scores children with HSPN. Methods: We performed a retrospective study 877 single center between 2001 2019. primary outcome defined as chronic...
Sinomenine (SN, 1) is a pure compound extracted from the Sinomenium acutum plant. We investigated protective effects and mechanism of action SN in rat model doxorubicin (DOX)-induced nephrosis. Nephrosis was induced by single dose 5 mg/kg DOX, DOX-treated rats received daily i.p. injection 10 or 30 SN, saline (n = 6). Urine serum biochemical parameters, TNF-α IL-1β levels, nephrin, podocin, α-actinin-4, peroxisome proliferator-activated receptor-α (PPAR-α) protein expression, renal...
MicroRNA‑106b (miR‑106b) is reported to be closely associated with skeletal muscle insulin resistance. The present study further investigated the role of miR‑106b in sensitivity and glucose homeostasis vivo. Mice were randomly divided into 4 groups infected lentivirus expressing (miR‑106b mice), sponge inhibition mice) or corresponding empty vectors. Mitofusion‑2 (Mfn2) protein expression levels transporter (Glut)‑4 translocation significantly reduced mice, whereas they unaffected mice. mice...
Kidney disease is manifested in a wide variety of phenotypes, many which have an important hereditary component. To delineate the genotypic and phenotypic spectrum pediatric nephropathy, multicenter registration system being implemented based on Chinese Children Genetic Disease Database (CCGKDD). In this study, all patients with kidney urological diseases were recruited from 2014 to 2020. analysis was conducted using exome sequencing for families multiple affected individuals nephropathy or...
Introduction:The pandemic of SARS-CoV-2 brings great challenge and threats to humans worldwide.Multiple variants tend be epidemic, among which Omicron is highly infectious within China.The aim this study was analyze the clinical characteristics children infected with variant B.1.1.529(Omicron) in Shanghai, China.Methods: We included 9378 pediatric patients diagnosed treated Shanghai International Convention Exhibition Center between April 1, 2022 May 31, 2022.We recorded summarized...