A5060247412- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Molecular Sensors and Ion Detection
- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Supramolecular Chemistry and Complexes
- Biosensors and Analytical Detection
- MicroRNA in disease regulation
- Polysaccharides and Plant Cell Walls
- Cancer-related Molecular Pathways
- Aquatic Ecosystems and Phytoplankton Dynamics
- Bacteriophages and microbial interactions
- Peptidase Inhibition and Analysis
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Advanced Nanomaterials in Catalysis
- Cancer Immunotherapy and Biomarkers
- Graphene and Nanomaterials Applications
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
Chongqing University
2017-2025
Beijing Normal University
2010-2025
Kunming Medical University
2022-2025
Fuling Center Hospital of Chongqing
2022-2025
Affiliated Hospital of Southwest Medical University
2020-2025
Nanjing University
2012-2024
Shenyang Institute of Automation
2019-2024
Southwest Jiaotong University
2021-2024
Chinese Academy of Sciences
2019-2024
China Agricultural University
2024
Abstract New strategies with high antimicrobial efficacy against multidrug-resistant bacteria are urgently desired. Herein, we describe a smart triple-functional nanostructure, namely TRIDENT (Thermo-Responsive-Inspired Drug-Delivery Nano-Transporter), for reliable bacterial eradication. The robust antibacterial effectiveness is attributed to the integrated fluorescence monitoring and synergistic chemo-photothermal killing. We notice that temperature rises generated by near-infrared...
Multiplexed detection of extracellular vesicle (EV)-derived microRNAs (miRNAs) plays a critical role in facilitating disease diagnosis and prognosis evaluation. Herein, we developed highly specific nucleic acid platform for simultaneous quantification several EV-derived miRNAs constant temperature by integrating the advantages clustered regularly interspaced short palindromic repeats/CRISPR associated nucleases (CRISPR/Cas) system rolling circular amplification (RCA) techniques....
Graphene quantum dots (GQDs)-based nanohybrid materials have gained great attention in multiple research applications, particularly biomedical fields due to their unique physicochemical properties and outstanding biocompatibility compared other nanomaterials. In this review, we focus on the most recent emerging developments including synthesis methods, vivo imaging vitro biosensing applications. We also discuss these unresolved problematic controversial issues facing Consequently, trends...
Recent investigations into heterochronic parabiosis have unveiled robust rejuvenating effects of young blood on aged tissues. However, the specific mechanisms remain incompletely elucidated. Here we demonstrate that small extracellular vesicles (sEVs) from plasma mice counteract pre-existing aging at molecular, mitochondrial, cellular and physiological levels. Intravenous injection sEVs extends their lifespan, mitigates senescent phenotypes ameliorates age-associated functional declines in...
Surgery is the mainstay of treatment modality for malignant melanoma. However, deteriorative hypoxic microenvironment after surgery recognized as a stemming cause tumor recurrence/metastasis and delayed wound healing. Here we design construct sprayable therapeutic hydrogel (HIL@Z/P/H) encapsulating tumor-targeted nanodrug photosynthetic cyanobacteria (PCC 7942) to prevent while promote In postsurgical B16F10 melanoma model in female mice, can disrupt cellular redox homeostasis via...
Connexin 43 (Cx43α1) gap junction has been shown to have an essential role in mediating functional coupling of neural crest cells and modulating cell migration. Here, we showed that N-cadherin wnt1 are required for efficient dye but not the expression Cx43α1 junctions cells. Cell motility was found be altered N-cadherin–deficient cells, alterations were different from elicited by deficiency. In contrast, wnt1-deficient no discernible change motility. These observations suggest may a good...
Endothelial cells express two classic cadherins, VE-cadherin and N-cadherin. The importance of in vascular development is well known; however, the function N-cadherin endothelial remains poorly understood. Contrary to previous studies, we found that localizes cell–cell junctions addition its well-known diffusive membrane expression. To investigate role development, was specifically deleted from mice. Loss results embryonic lethality at mid-gestation due severe defects. Intriguingly, loss...
Microcystins have been reported to be carcinogenic by animal and cell experimentation, but there are no data on the linkage between serum microcystins hepatocellular carcinoma (HCC) risk in humans. We conducted a clinical case-control study investigate association HCC after controlling several known factors, such as hepatitis B virus, alcohol, aflatoxin. From December 2013 May 2016, 214 patients newly diagnosed with along controls (frequency-matched age sex) were recruited from three...
Accurate identification of exosomes plays an essential role in facilitating disease diagnosis and therapies. Herein, we proposed Aptamer-cholesterol-mediated Proximity Ligation Assay (AcmPLA) for accurate a dual-probe strategy, one aptamer probe recognition exosomal innate surface protein CD63 another cholesterol biolipid layer targeting. By integrating proximity ligation probes bound with biomarkers specific rolling circle amplification (RCA) strategy signal amplification, have successfully...
Extracellular vesicles (EVs) are emerging as promising biomarkers for cancer diagnosis and therapy. Recognizing low-abundance EVs from clinical samples in an easy-to-operate way is highly desired but remains a challenge. Herein, we established allosteric probe-initiated dual cycle amplification-assisted CRISPR-Cas12a (AID-Cas) platform sensitive detection of wash-free way. In AID-Cas, the probe can specifically recognize bind with target thus initiate following dual-cycle amplification....
Cuproptosis, a newly discovered form of cell death, is regulated by protein lipoylation and related to mitochondrial metabolism. However, further research needed determine how the cuproptosis-related gene ferredoxin 1 (FDX1) affects tumor immune response its prognostic significance in clear renal carcinoma (ccRCC).The Cancer Genome Atlas was used screen for FDX1 expression ccRCC healthy tissue samples. The results were validated using Gene Expression Omnibus Human Protein Atlas....
Aberrant energy metabolism not only endows tumor cells with unlimited proliferative capacity but also contributes to the establishment of glucose-deficient/lactate-rich immunosuppressive microenvironment (ITM) impairing antitumor immunity. Herein, a novel metabolic nanoregulator (D/B/CQ@ZIF-8@CS) was developed by enveloping 2-deoxy-d-glucose (2-DG), BAY-876, and chloroquine (CQ) into zeolitic imidazolate framework-8 (ZIF-8) simultaneously deprive energy/nutrition supply relieve ITM for...
Abstract Smart hydrogel sensors, functioning as implantable devices, play a vital role in health monitoring and early warning, overcoming the limitations of conventional clinical methods to achieve direct, continuous, precise monitoring. Widely employed across various biomedical fields, these sensors offer unique advantages for monitoring, ensuring highly accurate In addition detecting biomolecules, smart with their flexibility biocompatibility, monitor disease‐specific markers, insights...
Mixed ion–electron conductive (MIEC) bioelectronics has emerged as a state-of-the-art type of for bioelectrical signal monitoring. However, existing MIEC is limited by delamination and transmission defects in signals. Herein, topological MXene network enhanced hydrogel that simultaneously exhibits both electrical mechanical property enhancement while maintaining adhesion biocompatibility, providing an ideal electrophysiological monitoring, introduced. Compared with nontopology...
The contractile force of the cardiomyocyte is transmitted through adherens junction, a component intercalated disc, enabling myocardium to function as syncytium. cadherin family cell adhesion receptors, located in interact homophilically mediate strong cell-cell adhesion. Ectopic expression cadherins associated with changes tumor behavior and pathology. To examine effect specificity on cardiac structure function, we expressed either epithelial cadherin, E-cadherin, or N-cadherin heart...
MicroRNAs (miRNAs) are present in body fluids and may have the potential to serve as disease biomarkers. This study explored clinical value of miRNAs serum urine biomarkers for idiopathic childhood nephrotic syndrome (NS).We obtained samples from 159 NS children (24 steroid resistant 135 sensitive), 109 age/sex-matched healthy controls 44 with other kidney diseases. Serum were analyzed TaqMan Low Density Array then validated a quantitative reverse-transcription PCR assay 126 individual...
Although the nephrotoxicity of microcystin and aflatoxin has been observed in animal clinical cases, few population data are available. We conducted a cross-sectional study Southwest China to investigate association renal function indicators (RFIs, including BUN, SCr, eGFR) with exposure 5493 members general population. Microcystin-LR levels water aquatic products B1 daily foods were measured by ELISA, individual estimated intake (EDI) was assessed on basis measurement questionnaire. found...