A5075903610- Catalytic C–H Functionalization Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic Cross-Coupling Reactions
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Catalytic Alkyne Reactions
- Chemical Synthesis and Reactions
- Oxidative Organic Chemistry Reactions
- Cyclopropane Reaction Mechanisms
- Asymmetric Synthesis and Catalysis
- Infectious Diseases and Tuberculosis
- Chemical Synthesis and Analysis
- Spine and Intervertebral Disc Pathology
- Asymmetric Hydrogenation and Catalysis
- Orthopedic Infections and Treatments
- Vanadium and Halogenation Chemistry
- Fluorine in Organic Chemistry
- Crystallography and molecular interactions
- Click Chemistry and Applications
- Synthetic Organic Chemistry Methods
- Spinal Fractures and Fixation Techniques
- Synthesis and biological activity
- Chemical synthesis and alkaloids
- Ionic liquids properties and applications
South China University of Technology
2016-2025
Shaoguan University
2022-2025
National Engineering Research Center of Electromagnetic Radiation Control Materials
2024
University of Electronic Science and Technology of China
2020-2024
University of Liverpool
2024
Kunming Children's Hospital
2022-2023
Dalian University of Technology
2023
State Key Laboratory of Pulp and Paper Engineering
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017-2022
Chongqing Medical University
2017-2022
Recent investigations into heterochronic parabiosis have unveiled robust rejuvenating effects of young blood on aged tissues. However, the specific mechanisms remain incompletely elucidated. Here we demonstrate that small extracellular vesicles (sEVs) from plasma mice counteract pre-existing aging at molecular, mitochondrial, cellular and physiological levels. Intravenous injection sEVs extends their lifespan, mitigates senescent phenotypes ameliorates age-associated functional declines in...
1,3,5-Tri(1H-benzo[d]imidazol-2-yl)benzene derivatives, as a new kind of fluorescent chemosensor for the detection nitroaromatic explosives, are designed and synthesized by simple N-hydrocarbylation. Among 16 obtained compounds, compound 4g has best capability picric acid (PA), having good selectivity high sensitivity. The PA with solution-coated paper strips at picogram level is developed. A simple, portable, low-cost method provided detecting in solution contact mode.
A concise copper-catalyzed N-O bond cleavage/C-C/C-N formation procedure has been described for the synthesis of multisubstituted pyridines. Various oxime acetates, activated methylene compounds, and a wide range aldehydes bearing aryl, heteroaryl, vinyl, trifluoromethyl groups were employed to provide tri- or tetrasubstituted pyridines with flexible substitution patterns. Moreover, this method features inexpensive catalysts, no need extra oxidant, high step-enconomy, which make it pratical...
Ionic liquids (ILs) can behave as green solvents in comparison with conventional organic solvents, but more often they also act ligands, co‐catalysts, and stabilizing agents both for metal active species intermediates of catalytic systems. In this review we have mainly summarized the recent achievements (2013 to present) Pd‐catalyzed cross‐coupling ILs assembly structurally diverse highly functionalized molecules, focus on cascade reactions triggered by nucleopalladation, Suzuki coupling,...
Abstract A highly efficient and mild palladium‐catalyzed, one‐pot, four‐step cascade annulation has been developed to afford functionalized β‐ γ‐lactones in moderate good yields with high regio‐ diastereoselectivities ionic liquids. The employment of liquids under reaction conditions makes this transformation green practical. Especially, provided a novel convenient methodology for the construction naturally occurring biologically active γ‐lactones.
This review summarized the recent developments in palladium-catalyzed C–S bond formation involving sulfenylation and sulfonylation reactions.
A copper-catalyzed aerobic oxidative reaction between aromatics or heteroaromatics with KSCN is developed by using O2 as the oxidant. The combination of Cu(OTf)2, N,N,N′,N′-tetramethylethylenediamine (TMEDA) and BF3·Et2O provides an efficient catalytic system, affording substituted thiocyanation products 2-aminobenzothiazoles in excellent yields. also possesses a good functional group tolerance for both strong electron-withdrawing electron-donating groups.
An efficient and convenient palladium-catalyzed C-H bond oxidative sulfenylation of indoles related electron-rich heteroarenes with aryl boronic acids elemental sulfur has been described. This procedure provides a useful direct approach for the assembly wide range structurally diverse 3-sulfenylheteroarenes moderate to excellent yields from simple readily available starting materials. Moreover, this synthetic protocol is suitable N-protected unprotected indoles. Notably, construction two C-S...
A novel and versatile method for the synthesis of 2H-imidazoles via iron-catalyzed [3 + 2] annulation from readily available oxime acetates with vinyl azides has been developed. This denitrogenative process involved N–O/N–N bond cleavages two C–N formations to furnish 2,4-substituted 2H-imidazoles. protocol was performed under mild reaction conditions needed no additives or ligands. Furthermore, this is a green involving acetate as internal oxidant, acetic acid, nitrogen byproducts.
This review summarizes recent advances in transition metal-catalyzed or metal-free aminative difunctionalization of alkenes to construct nitrogen-containing compounds.
A novel and efficient palladium-catalyzed cascade annulation/arylthiolation reaction has been developed to afford functionalized 3-sulfenylbenzofuran 3-sulfenylindole derivatives in moderate good yields from readily available 2-alkynylphenols 2-alkynylamines ionic liquids. This protocol provides a valuable synthetic tool for the assembly of wide range with high atom- step-economy exceptional functional group tolerance. Moreover, employment liquids under mild conditions makes this...
A novel copper-catalyzed C(sp<sup>3</sup>)–H oxidative functionalization of oxime acetates for the synthesis enaminones under redox-neutral conditions has been developed.
An efficient and robust protocol for the preparation of 3-substituted isocoumarins via palladium-catalyzed nucleophilic addition/oxidative annulation bromoalkynes with benzoic acids has been developed. Remarkably, preliminary mechanistic studies indicated that transformation might proceed a stereo- regioselective addition C–H functionalization procedure.
The first examples of palladium-catalyzed allylic C–H oxidative allylation sulfoxonium ylides to afford the corresponding conjugated dienones with moderate good yields have been established. features this novel conversion include mild reaction conditions, wide substrate scope, and excellent regioselectivity.
Abstract A regio‐ and stereoselective method for the preparation of ( Z )‐vinyl thiocyanate derivatives by silver‐catalyzed thiocyanation haloalkynes is reported. This features practical, free ligand, broad substrate scope, excellent stereoselectivity gram‐scale synthesis. Significantly, halogen atom retained, which allows synthesis 2,5‐diphenylthiophene, thiazol‐2‐amine trifluoromethyl sulfides via simple transformation. magnified image
A new approach to construct 2,3-disubstituted quinolines is described via Pd-catalyzed oxidative cyclization of o-vinylanilines and alkynes with molecular oxygen. This transformation supposed undergo intermolecular amination alkyne, insertion the olefin, cleavage C–C bond sequence.
Object To compare the clinical efficacy of titanium mesh cages and autogenous iliac bone graft to restore vertebral height through posterior approach in patients with thoracic lumbar spinal tuberculosis. Method 59 tuberculosis underwent interbody fusion internal fixation our department from January 2011 December 2013. In group A, 34 obtained for reconstruction height, among them 25 (group A1) suffered single-segment tuberculosis, 9 patients, A2) had multi-segment B, got including 24 B1), 1...
This review summarized the recent developments in metal catalyzed or mediated cyclization/functionalization of alkynes to construct isoxazoles.
Abstract A novel and convenient palladium catalytic system for the synthesis of α‐amino acid esters from simple starting materials is reported. Hydrogen peroxide not only acts as green oxidant, but also oxygen source. This strategy conversion amines vinyl ethers into highly functionalized structurally diverse characterized by simplicity experimental procedure, mild reaction conditions, high atom economy, scalability, practicability.
Palladium-catalyzed aerobic oxidative direct allylic C–H arylation of alkenes, with polyfluorobenzenes, for the creation allyl–aryl bonds, is reported.
An efficient and practical palladium-catalyzed aerobic oxidative approach to afford functionalized 2-substituted quinolines in moderate good yields from readily available allylbenzenes with aniline is developed. The present annulation process has high functional-group tolerance atom economy, making it a valuable method synthetic medicinal chemistry. Moreover, this transformation supposed proceed through oxidation of allylic C-H functionalization form C-C C-N bonds one pot.
A copper-catalyzed [3+2] annulation of oxime acetates and xanthates to generate thiazol-2-yl ethers with good regioselectivity under redox-neutral conditions has been developed.
An efficient and environmentally benign iodine-catalyzed cascade cyclization has been achieved to afford functionalized 3-sulfenylcoumarin 3-sulfenylquinolinone derivatives.
A novel chloropalladation-initiated intermolecular oxyvinylcyclization of alkenes with alkynoic acids or alkynols is developed. This protocol provides a series 3-methylene γ-lactone and tetrahydrofuran derivatives in moderate to excellent yields high stereoselectivities the presence PdCl2 CuCl2 CuCl2·2H2O. Besides broad substrate scope, this method has advantages mild reaction conditions easily accessible starting materials. Furthermore, construction C-Cl, C(sp(2))-C(sp(3)), C-O bonds one...