A5100655654- Nutrition and Health in Aging
- Dialysis and Renal Disease Management
- Respiratory viral infections research
- Extracellular vesicles in disease
- Immune Response and Inflammation
- Sinusitis and nasal conditions
- Vaccine Coverage and Hesitancy
- Pneumonia and Respiratory Infections
- Influenza Virus Research Studies
- Chronic Kidney Disease and Diabetes
- Allergic Rhinitis and Sensitization
- Peripheral Artery Disease Management
- Birth, Development, and Health
- Bacterial Infections and Vaccines
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- MRI in cancer diagnosis
- Congenital Diaphragmatic Hernia Studies
- interferon and immune responses
- Asthma and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Clinical Nutrition and Gastroenterology
- Cellular Mechanics and Interactions
- Iron Metabolism and Disorders
- Blood Pressure and Hypertension Studies
Sun Yat-sen University
2023-2025
Third Affiliated Hospital of Sun Yat-sen University
2023-2025
Harbin Engineering University
2025
University of California, Irvine
2019-2024
Nanjing University
2024
Nanjing Drum Tower Hospital
2024
Zhejiang University
2024
First Affiliated Hospital Zhejiang University
2024
Chengdu University of Traditional Chinese Medicine
2024
Shanghai International Medical Center
2023
Recent investigations into heterochronic parabiosis have unveiled robust rejuvenating effects of young blood on aged tissues. However, the specific mechanisms remain incompletely elucidated. Here we demonstrate that small extracellular vesicles (sEVs) from plasma mice counteract pre-existing aging at molecular, mitochondrial, cellular and physiological levels. Intravenous injection sEVs extends their lifespan, mitigates senescent phenotypes ameliorates age-associated functional declines in...
Receptor-binding specificity of HA, the major surface glycoprotein influenza virus, primarily determines host ranges that virus can infect. Influenza type B almost exclusively infects humans and contributes to annual "flu" sickness. Here we report structures HA in complex with human avian receptor analogs, respectively. These provide a structural basis for different receptor-binding properties A molecules ability distinguish receptors. The structure analog also reveals how mutations region...
Echinatin is an active ingredient in licorice, a traditional Chinese medicine used the treatment of inflammatory disorders. However, protective effect and underlying mechanism echinatin against acute lung injury (ALI) still unclear. Herein, we aimed to explore echinatin-mediated anti-inflammatory effects on lipopolysaccharide (LPS)-stimulated ALI its molecular mechanisms macrophages. In vitro , markedly decreased levels nitric oxide (NO) prostaglandin E2 (PGE 2 ) LPS-stimulated murine MH-S...
In observational studies, higher uric acid levels are associated with metabolic syndrome, diabetes, and kidney disease.The objective of this study is to examine whether reduction plasma febuxostat, a xanthine oxido reductase inhibitor, impacts adipose tissue oxidative stress, adipokines, markers systemic inflammation or fibrosis.This was double-blinded randomized controlled trial.Academic university setting used.Overweight obese adults hyperuricemia type 2 diabetic nephropathy were...
Systemic inflammatory response syndrome (SIRS) remains a serious health problem that consumes large amount of medical resources. The objective the study was to investigate whether older patients with high neutrophil high-density lipoprotein ratio (NHR) before surgery were more susceptible postoperative SIRS. This retrospective cohort conducted on than 65 years admitted two campuses Third Affiliated Hospital Sun Yat-sen University between January 2015 and September 2020. Patient baseline...
Abstract To improve the efficiency and application prospects of metal peroxides in tumor therapy, synthesis bimetallic via simple yet effective approaches will be highly significant. In this work, hyaluronic acid modified zinc‐copper (ZCPO@HA) nanoparticles are synthesized through a one‐step symbiotic method by co‐hydrolysis zinc acetate copper weakly alkaline solution, followed modification with sodium hyaluronate. Upon decomposition microenvironment, ZCPO@HA can generate considerable...
Acute respiratory distress syndrome (ARDS) is a condition caused by severe endothelial barrier dysfunction within the lung. In ARDS, excessive inflammation, tissue edema, and immune cell influx prevents regeneration that crucial in repairing barrier. However, little known about molecular mechanism underpin ARDS.R-based bioinformatics tools were used to analyze microarray-derived transcription profiles human lung microvascular cells (HLMVECs) subjected non-treatment or lipopolysaccharide...
Leiomodin (Lmod) is a class of potent tandem-G-actin-binding nucleators in muscle cells. Lmod mutations, deletion, or instability are linked to lethal nemaline myopathy. However, the lack high-resolution structures action severely hampered our understanding their essential cellular functions. Here we report crystal structure actin-Lmod2162-495 nucleus. The contains two actin subunits connected by one Lmod2162-495 molecule non-filament-like conformation. Complementary functional studies...
Evidence from previous epidemiological studies on the effect of physical activity risk Alzheimer's disease (AD) is conflicting. We performed a two-sample Mendelian randomization analysis to verify whether causally associated with AD. This study used (MR) estimate association between (including overall activity, sedentary behavior, walking, and moderate-intensity activity) Genetic instruments for were obtained published genome-wide (GWAS) including 91,105 individuals UK Biobank. Summary-level...
Abstract Background and Aim Small ubiquitin–like modifier (SUMO)‐specific protease (SENP)3 is a molecule that responds to reactive oxygen species (ROS) with high sensitivity. However, the role of ROS SENP3 in formation nasal polyps (NPs) remains unclear. This study aimed explore how influenced outcome chronic rhinosinusitis (CRS) by altering macrophage function, is, NPs. Methods The alternative activation (M2) was detected CD68 + CD206 humans mice. mucosa patients CRS tested using flow...
Spontaneous nucleation of actin is very inefficient in cells. To overcome this barrier, cells have evolved a set filament nucleators to promote rapid and polymerization response specific stimuli. However, the molecular mechanism remains poorly understood. This hindered largely by fact that nucleus, once formed, rapidly polymerizes into filament, thus making it impossible capture stable multisubunit nucleus. Here, we report an effective double-mutant strategy stabilize nucleus preventing...
Programmed death-ligand 1 (PD-L1) and T cell immunoreceptor with Ig ITIM domains (TIGIT) are two potential targets for cancer immunotherapy, early clinical studies showed the combination therapy of anti-PD-L1 anti-TIGIT had synergistic efficacy both in terms overall response rate (ORR) survival (OS). It is rational to construct bispecific antibodies targeting PD-L1 TIGIT, besides retaining therapy, (BsAbs) can provide a new mechanism action, such as bridging between tumor cells T/NK cells....
The “obesity paradox in acute respiratory distress syndrome” (ARDS) refers to the phenomenon which obesity is associated with higher morbidity but lower mortality patients ARDS. Endothelial-to-mesenchymal transition (EndMT) represents a key link interaction between endothelial disruption and mesenchymal fibrosis under inflammatory oxidative conditions, represent intersectional pathophysiology of Adipose tissue considered constitute major source circulating exosomal microRNAs (miRNAs), act as...
Toll-like receptor 2 and 4 (TLR2, TLR4) signaling is implicated in atherosclerotic plaque formation. The two-stage master regulator Virtual Inference of Protein-activity by Enriched Regulon (VIPER) analysis macrophage TLR2 TLR4 signature genes integrated with coexpression network derived from 371 patient-derived carotid specimens identifies activated RNA polymerase II transcriptional coactivator p15 (SUB1/Sub1, PC4) as a regulon the atherogenic TLR response. It found that proinflammatory...
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, world’s deadliest infectious disease. Mtb uses a variety mechanisms to evade human host’s defenses and survive intracellularly. Mtb’s oxidative stress response enables within activated macrophages, an environment with reactive oxygen species low pH. Dye-decolorizing peroxidase (DyP), enzyme involved in response, encapsulated nanocompartment, encapsulin (Enc), important for survival macrophages. Encs are homologs viral...
IntroductionThe associations of dietary protein and/or energy intakes with or wasting in patients on maintenance hemodialysis are controversial. We examined these the Hemodialysis (HEMO) Study.MethodsIn 1487 participants HEMO Study, baseline intake (grams per kilogram day) and (kilocalories kilograms were related to presence protein-energy (PEW) syndrome at month 12 (defined as least 1 criteria 2 3 categories low serum chemistry, body mass, muscle mass) logistic regression models. In...