A5021231933- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- Demographic Trends and Gender Preferences
- Nanoparticle-Based Drug Delivery
- vaccines and immunoinformatics approaches
- Foot and Ankle Surgery
- Global Maternal and Child Health
- Angiogenesis and VEGF in Cancer
- Toxin Mechanisms and Immunotoxins
- Bone and Dental Protein Studies
- Peptidase Inhibition and Analysis
- Radiopharmaceutical Chemistry and Applications
- Lymphoma Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- T-cell and B-cell Immunology
- Advanced Battery Materials and Technologies
- Advancements in Battery Materials
- Cell Adhesion Molecules Research
- Protein purification and stability
- Bone fractures and treatments
Henan Provincial People's Hospital
2013-2025
Henan University
2025
Sichuan University
2017-2024
West China Hospital of Sichuan University
2017-2024
Regend Therapeutics (China)
2024
Beijing Institute of Technology
2022-2024
Hengyang Normal University
2024
National University of Defense Technology
2022-2024
University of Science and Technology Beijing
2024
Central South University
2022-2024
Abstract Son preference has persisted in the face of sweeping economic and social changes countries studied here. We attribute this persistence to their similar family systems, which generate strong disincentives raise daughters – whether or not marriages require dowries while valuing adult women's contributions household. Urbanisation, female education employment can only slowly change these incentives without more direct efforts by state civil society increase flexibility kinship system...
In this article the causes and implications of recent reported sex ratio increase after 1980s in China are analyzed. The ought to have been 106 male/100 female births absence social behavioral interference. However began 1981 at 108.5 is currently 113.8 (1989). ratios for 0-4 years increased similarly; with parity. At parity 4 or more 1989 was 131.7. Hull says possible infanticide prenatal identification followed by gender-specific induced abortion underreporting births. Johansson Hygren...
// Liangliang Wu 1, * , Zhaoyang Deng 2, Yaojun Peng 1 Lu Han 3 Jing Liu Linxiong Wang Bohua Li 4 Jian Zhao Shunchang Jiao and Huafeng Wei Key Lab of Cancer Center, General Hospital Chinese PLA & Beijing Laboratory Cell Engineering Antibody, Beijing, China 2 Surgical Division, PLA, Department Internal Oncology, Shanghai for Molecular Imaging, University Medicine Health Sciences, Shanghai, These authors have contributed equally to the work Correspondence to: Wei, email: foxp3_smmu@163.com...
Abstract Although molybdenum trioxide nanomaterials have been widely explored as nanoagents for biomedical applications against bacteria through photothermal therapy, chemodynamic and catalytic their utilization photosensitizers photodynamic therapy (PDT) rarely reported so far. Herein, we report the activation of MoO 3 nanobelts via aqueous co‐intercalation Na + H 2 O into van der Waals gaps a near‐infrared Type I photosensitizer periodontitis treatment. The /H intercalation can shorten its...
Lithium-oxygen batteries (LOBs) are well known for their high energy density. However, reversibility and rate performance challenged due to the sluggish oxygen reduction/evolution reactions (ORR/OER) kinetics, serious side uncontrollable Li dendrite growth. The electrolyte plays a key role in transport of Li+ reactive species LOBs. Here, we tailored dilute by screening suitable crown ether additives promote lithium salt dissociation solvation through electrostatic interaction. containing 100...
Rituximab is a widely used monoclonal antibody drug for treating certain lymphomas and autoimmune diseases. To understand the molecular mechanism of recognition human CD20 by Rituximab, we determined crystal structure Fab in complex with synthesized peptide comprising epitope (residues 163-187) at 2.6-A resolution. The combining site consists four complementarity determining regions that form large, deep pocket to accommodate peptide. bound assumes unique cyclic conformation constrained...
The considerable increase in educational attainment of Chinese women from virtual complete illiteracy 50 years ago to current levels can be traced systematically for the first time on basis 1982 census China and a large sample survey same year. Until very recently we had known only broad outlines this major social transformation. Although even newly available data are imperfect, their significance is illustrated by strong consistent association with such vital facts life as age at which...
Radiotherapy for esophageal squamous cell carcinoma (ESCC) patients is limited by resistance to ionizing radiation (IR). However, the roles and mechanisms of microRNAs in radioresistance are obscure. Here, we investigated that microRNA-205 (miR-205) was upregulated radioresistant (RR) ESCC cells compared with parental cells. Overexpression miR-205 promoted colony survival post-IR, whereas depletion sensitized IR vitro vivo. Further, demonstrated enhancing DNA repair, inhibiting apoptosis...
CD11c is an antigen receptor predominantly expressed on dendritic cells (DC), to which targeting has been shown induce robust antigen-specific immune responses. To facilitate targeted delivery of tumor antigens DCs, we generated fusion proteins consisting the extracellular domain human HER or its rat homologue neu, fused single-chain fragment variable specific for (scFv(CD11c)-HER2/neu).Induction cellular and humoral responses antitumoral activity admixed with DC-activating CpG...
Aims: To develop novel iRGD (internalizing Arg-Gly-Asp peptide)-conjugated DSPE-PEG2000 nanomicelles (M-SAL-iRGD) for delivery of salinomycin to both liver cancer cells and stem (CSCs). Materials & methods: The characterization, antitumor activity mechanism action M-SAL-iRGD were evaluated. Results conclusion: possessed a small size around 10 nm, drug encapsulation efficacy higher than 90%. showed significantly increased cytotoxic effect toward nontargeted M-SAL (salinomycin-loaded...
Abstract Tumor metastasis leads to high mortality; therefore, understanding the mechanisms that underlie tumor is crucial. Generally seen as a secretory protein, osteopontin (OPN) involved in multifarious pathophysiological events. Here, we present novel pro-metastatic role of OPN during metastatic colonization. Unlike (sOPN), which triggers epithelial–mesenchymal transition (EMT) initiate cancer metastasis, intracellular/nuclear (iOPN) induces mesenchymal–epithelial (MET) facilitate...
Immune checkpoint inhibitors (ICI) have transformed cancer treatment. However, only a minority of patients achieve profound response. Many are innately resistant while others acquire resistance to ICIs. Furthermore, hepatotoxicity and suboptimal efficacy hampered the clinical development agonists 4-1BB, promising immune-stimulating target. To effectively target 4-1BB treat diseases ICIs, we engineered ATG-101, tetravalent "2+2″ PD-L1×4-1BB bispecific antibody. ATG-101 bound PD-L1...
The use of electric furnace ferronickel slag (FNS) as a supplementary cementitious material is the current focus research. This study investigates effect mechanical grinding and chemical additives on activity excition FNS, well associated synergistic mechanisms. shows that addition triethanolamine (TEA) increases fine-grained content in FNS powder, which facilitates depolymerization early hydration aluminum tricalcium. Furthermore, Ca(OH)2 raises alkalinity system, promotes availability Ca2+...
Abstract Despite the effectiveness of anti-CD20 monoclonal antibody (mAb) Rituximab (C2B8) in treatment B-cell lymphoma, its efficacy remains variable and often modest. It seems likely that a combination multiple mechanisms, such as complement-dependent cytotoxicity (CDC) apoptotic signaling, underlies therapeutic success mAbs. Unfortunately, all current mAbs effective CDC are relatively inactive signaling cell death vice versa. In this study, we developed two genetically engineered...