A5089850418- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Apelin-related biomedical research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal and related cancers
- Ion Transport and Channel Regulation
- Advanced Glycation End Products research
- Electrolyte and hormonal disorders
- Pancreatic function and diabetes
- Parathyroid Disorders and Treatments
- Diabetes and associated disorders
- Retinal Diseases and Treatments
- Renal and Vascular Pathologies
- Pregnancy and preeclampsia studies
- Protease and Inhibitor Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Phagocytosis and Immune Regulation
- Glycosylation and Glycoproteins Research
- Fault Detection and Control Systems
- Vasculitis and related conditions
- Nuclear Receptors and Signaling
- RNA Research and Splicing
- Nitric Oxide and Endothelin Effects
University of Utah
2016-2025
Hangzhou Dianzi University
2023-2024
University of Science and Technology Liaoning
2024
The First People's Hospital of Tianmen
2024
Nanjing University of Aeronautics and Astronautics
2024
University of Utah Health Care
2022
Nantong University
2018
North China Electric Power University
2009
Recombinant Antibody Technology (United Kingdom)
2004
Shanghai First People's Hospital
2003
Collagen, the major structural component of nearly all mammalian tissues, undergoes extensive proteolytic remodeling during developmental states and a variety life-threatening diseases such as cancer, myocardial infarction, fibrosis. While degraded collagen could be an important marker tissue damage, it is difficult to detect target using conventional tools. Here, we show that designed peptide (collagen hybridizing peptide: CHP), which specifically hybridizes degraded, unfolded chains, can...
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of antidiabetic oral agents indicating promising effects on cardiovascular and renal end points. However, the renoprotective SGLT2 not fully understood. Also, metabolic inhibition other organ systems, such as hepatic steatosis, This study sought to address these questions by treating 18-wk-old uninephrectomized db/db mice with selective inhibitor dapagliflozin. Untreated developed progressive albuminuria, glomerular mesangial...
In fibrotic renal disease, elevated TGF-β and angiotensin II lead to increased plasminogen activator inhibitor type 1 (PAI-1). PAI-1 appears reduce glomerular mesangial matrix turnover by inhibiting activators, thereby decreasing plasmin generation plasmin-mediated degradation. We hypothesized that therapy with a mutant human (PAI-1R) binds vitronectin but does not inhibit would enhance generation, increase turnover, decrease accumulation in experimental glomerulonephritis. Three groups...
Excess mineralocorticoid receptor (MR) activation promotes target organ dysfunction, vascular injury and fibrosis. MR antagonists like eplerenone are used for treating heart failure, but their use is limited due to the compound class-inherent hyperkalemia risk. Here we present evidence that AZD9977, a first-in-class modulator shows cardio-renal protection despite mechanism-based reduced liability cause hyperkalemia. AZD9977 in vitro potency binding mode were characterized using reporter...
In fibrotic renal disease, elevated TGF-β and angiotensin II lead to increased plasminogen activator inhibitor type 1 (PAI-1). PAI-1 appears reduce glomerular mesangial matrix turnover by inhibiting activators, thereby decreasing plasmin generation plasmin-mediated degradation. We hypothesized that therapy with a mutant human (PAI-1R) binds vitronectin but does not inhibit would enhance generation, increase turnover, decrease accumulation in experimental glomerulonephritis. Three groups...
Plasminogen activator inhibitor-1 (PAI-1) has been implicated in renal fibrosis. In vitro, PAI-1 inhibits plasmin generation, and this decreases mesangial extracellular matrix turnover. PAI-1R, a mutant PAI-1, increases glomerular reverses inhibition of degradation, reduces disease experimental glomerulonephritis. This study sought to determine whether short-term administration PAI-1R could slow the progression glomerulosclerosis db/db mouse, model type 2 diabetes which accumulation is...
Recent identification of a counterregulatory axis the renin-angiotensin system, called angiotensin-converting enzyme 2-angiotensin-(1-7) [ANG-(1-7)]-Mas receptor, may offer new targets for treatment renal fibrosis. We hypothesized that therapy with ANG-(1-7) would improve glomerulosclerosis through counteracting ANG II in experimental glomerulonephritis. Disease was induced rats monoclonal anti-Thy-1 antibody, OX-7. Based on three-dose pilot study, 576 microg x kg(-1) day(-1) continuously...
In observational studies, higher uric acid levels are associated with metabolic syndrome, diabetes, and kidney disease.The objective of this study is to examine whether reduction plasma febuxostat, a xanthine oxido reductase inhibitor, impacts adipose tissue oxidative stress, adipokines, markers systemic inflammation or fibrosis.This was double-blinded randomized controlled trial.Academic university setting used.Overweight obese adults hyperuricemia type 2 diabetic nephropathy were...
Diabetic complications are linked to oxidative stress, which hampers the cyclic guanosine monophosphate production by inhibiting nitric oxide /soluble guanylate cyclase (sGC) signalling. This study aimed determine whether administration of a novel sGC activator avenciguat alone or in combination with SGLT2 inhibitor could slow progression renal and liver fibrosis type 2 diabetic uninephrectomized db/db mouse model. Experiment groups included normal controls, untreated mice terminated at 12...
Aldosterone is thought to modulate renal fibrosis, in part, through increasing plasminogen activator inhibitor type 1 (PAI-1), a major of ECM degradation. The present study investigated aldosterone effects on PAI-1 and transforming growth factor (TGF)-β asked whether were TGF-β mediated acted synergistically increase decrease Rat mesangial cells (MCs) fibroblast [normal rat kidney (NRK)-49F] used. 3 H-labeled was produced by MCs. effect degradation newly plated MCs or NRK-49F measured the...
Although elevated plasma prorenin levels are commonly found in diabetic patients and correlate with microvascular complications, the pathological role of these increases, if any, remains unclear. Prorenin/renin binding to prorenin/renin receptor [(p)RR] enhances efficiency angiotensinogen cleavage by renin unmasks catalytic activity. We asked whether could be activated local vascular tissue through binding. Immunohistochemical staining showing localization (p)RR aorta smooth muscle cells...
Higher doses of AngII (angiotensin II) blockers are intended to optimize albuminuria reduction rather than for blood pressure control in chronic kidney disease. However, the long-term renoprotection high-dose has yet be defined. The present study sought determine whether ARB (AngII receptor blocker) that maximally reduce proteinuria could slow progression glomerulosclerosis uninephrectomized db/db mouse, a model Type 2 diabetes. Untreated mice had normal pressure, but developed progressive...
Adiponectin (ApN) is a multifunctional adipokine. However, high, rather than low, concentrations of ApN are unexpectedly found in patients with chronic kidney disease (CKD) via an as yet unknown mechanism, and the role CKD unclear. Herein, we investigated effect overexpression on progressive renal injury resulting from deoxycorticosterone acetate-salt (DOCA) angiotensin II (ANG II) infusion using transgenic, inducible ApN-overexpressing mouse model. Three groups mice [wild type receiving no...
Adiponectin is a multifunctional adipokine with insulin-sensitizing, anti-inflammatory, and vasoprotective properties. Epidemiology studies have, however, shown that high levels of serum adiponectin are associated kidney disease progression. We, therefore, examined the effect administration on progression glomerulosclerosis in obese diabetic (db/db) mouse, model type II diabetes. Recombinant human was administered intraperitoneally at dose 30 or 150 μg per day from weeks 18 to 20....
Erythropoietin producing hepatocellular (Eph)-Eph receptor interacting (Ephrin) receptor-ligand signaling has been implicated in the development of tissue fibrosis, though it not well defined kidney. We detected substantial up-regulation expression and phosphorylation EphB2 tyrosine kinase fibrotic kidney obtained both from mice subjected to unilateral renal ischemia-reperfusion (IR) model at 14 days patients suffering chronic disease (CKD). Knockout (KO) lacking exhibited a normal structure...
The limited antifibrotic effect of therapeutic angiotensin blockade, the fact that blockade dramatically elevates renin levels, and recent evidence has an angiotensin-independent, receptor-mediated profibrotic action led us to hypothesize combining receptor inhibition ANG II would increase alone. Using cultured nephritic glomeruli from rats with anti-Thy-1-induced glomerulonephritis, maximally effective dose enalaprilate was determined be 10(-4) M, which reduced mRNAs for transforming growth...
Abstract Background Upregulation of an RNA-binding protein HuR has been implicated in glomerular diseases. Herein, we evaluated whether it is involved renal tubular fibrosis. Methods was firstly examined human kidney biopsy tissue with disease. Second, its expression and the effect inhibition KH3 on injury were further assessed a mouse model induced by unilateral ischemia/reperfusion (IR). (50 mg kg −1 ) given daily via intraperitoneal injection from day 3 to 14 after IR. Last, one...