A5074220267- Virology and Viral Diseases
- Tryptophan and brain disorders
- Cancer-related molecular mechanisms research
- Animal Virus Infections Studies
- MicroRNA in disease regulation
- Stress Responses and Cortisol
- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- Cervical and Thoracic Myelopathy
- RNA modifications and cancer
- Viral Infections and Vectors
- Viral Infections and Immunology Research
- Immune cells in cancer
- Circular RNAs in diseases
- Congenital heart defects research
- Atherosclerosis and Cardiovascular Diseases
- Molecular Biology Techniques and Applications
- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Mosquito-borne diseases and control
- Cerebrovascular and Carotid Artery Diseases
- Respiratory viral infections research
- Neuroscience and Neuropharmacology Research
- Nanoparticle-Based Drug Delivery
- RNA Research and Splicing
Second Affiliated Hospital of Chongqing Medical University
2015-2025
Chongqing Medical University
2015-2025
Dalian Medical University
2015-2025
Harbin Veterinary Research Institute
2025
Chinese Academy of Agricultural Sciences
2025
University of Miami
2024
Nanjing University of Chinese Medicine
2024
First People's Hospital of Yunnan Province
2016-2022
Kunming University of Science and Technology
2016-2022
Chongqing Academy of Environmental Science
2021-2022
Abstract Chronic stressful occurrences are documented as a vital cause of both depression and anxiety disorders. However, the stress-induced molecular mechanisms underlying common distinct pathophysiology these disorders remains largely unclear. We utilized chronic mild stress (CMS) rat model to differentiate subgroup depression-susceptible, anxiety-susceptible, insusceptible rats. The hippocampus was analyzed for differential proteomes by combining mass spectrometry isobaric tags relative...
Poly(lactide‐co‐glycolic acid) (PLGA) particles are biocompatible and biodegradable, can be used as a carrier for various chemotherapeutic drugs, imaging agents targeting moieties. Micrometer‐sized PLGA were synthesized with gold nanoparticles DiI dye within the shell, perfluorohexane liquid (PFH) in core. Upon laser irradiation, shell absorbs energy, activating core (liquid conversion to gas). The rapidly expanding gas is expelled from particle, resulting microbubble; this violent process...
Atherosclerosis is a hyperlipidemia-induced condition affecting the arterial wall that damages healthy endothelial cell (EC) function, leading to enhanced risk of atherothrombotic events. Certain microRNAs regulate EC dysfunction in response hyperlipidemia and may be suitable therapeutic targets combat atherosclerosis.
Abstract Chronic stress is a significant risk factor for depression as well anxiety disorders. Yet, the stress-induced specific and common molecular dysregulations of these disorders have not been fully understood. Previously, we constructed chronic mild (CMS) rat model to separate obtain depression-susceptible, anxiety-susceptible, insusceptible groups. In this study, prefrontal cortical proteomes three stressed groups were comparatively profiled utilizing isobaric tags relative absolute...
Tbx18, Wt1, and Tcf21 have been identified as epicardial markers during the early embryonic stage. However, gene of mature cells remain unclear. Single-cell transcriptomic analysis was performed with Seurat, Monocle, CellphoneDB packages in R software standard procedures. Spatial transcriptomics on chilled Visium Tissue Optimization Slides (10x Genomics) Gene Expression Genomics). Space Ranger software. Immunofluorescence, whole-mount RNA situ hybridization X-gal staining were to validate...
Abstract African swine fever (ASF), caused by virus (ASFV), has resulted in significant economic impacts on the global industry. Currently, there is no safe and effective commercial vaccine available for ASFV. Thus, development of readily therapeutics ASF urgently needed. To conduct high-throughput screening (HTS) anti-ASFV drugs, we initially developed a recombinant dual-reporter (rASFV-Gluc/EGFP) using virulent strain ASFV HLJ/18 (ASFV-WT). The enhanced green fluorescent protein (EGFP)-...
Clinical studies have shown that Compound Kushen Injection (CKI) can alleviate the inflammatory symptoms of radiation enteritis. However, mechanism action remains unclear. The aim this study was to explore possible targets and mechanisms CKI in treatment Network pharmacology used predict potential for enteritis, GO KEGG enrichment analyses were subsequently performed. SD rats randomly divided into one following groups: control, model, CB1 agonist, + antagonist. Except control group,...
Atherosclerosis and vessel wall trauma induce vascular smooth muscle cell (VSMC) phenotypic modulation, leading to plaque cap growth postintervention restenosis. Our systems biology approach identified RNA binding protein, mRNA processing factor ( RBPMS ) as a conserved, VSMC-specific gene associated with VSMC modulation in atherosclerosis. expression positively correlates contractile markers human murine atherosclerotic arteries well two injury models during the postinjury intimal...
Aryl Hydrocarbon Receptor-Interacting Protein (AIP) reduces macrophage cholesterol-ester accumulation and may prevent atherogenic foamy formation. Analyzing AIP-associated regulatory gene networks can aid in identifying key mechanism(s) underlying A weighted co-expression network analysis on the Stockholm Atherosclerosis Gene Expression (STAGE) patient cohort identifies AIP as a negative correlate of Histocompatibility Minor 13 (HM13), which encodes ER-associated degradation (ERAD) protein...
MicroRNA-126 (miR-126), one of the most abundant microRNAs in platelets, is involved regulation platelet activity and circulating miR-126 reduced during antiplatelet therapy. However, whether intraplatelet plays a role thrombosis inhibition remains unclear. Here, using tissue-specific knockout mice, we reported that deficiency platelets vascular endothelial cells significantly prevented prolonged bleeding time. Using chimeric identified lack thrombosis. Ex vivo experiments further...
Despite studies providing insight into the neurobiology of chronic stress, depression and anxiety, long noncoding RNA (lncRNA)-mediated mechanisms underlying common distinct pathophysiology these stress-induced disorders remain nonconclusive. In a previous study, we used mild stress paradigm to separate depression-susceptible, anxiety-susceptible insusceptible rat subpopulations. current lncRNA messenger (mRNA) expression was comparatively profiled in hippocampus three groups using...
Borna disease virus (BDV) is a neurotropic that produces neuropsychiatric dysfunction in wide range of warm-blooded species. Several studies have associated BDV with human psychiatric illness, but the findings remain controversial. Although oligodendrocytes are major glial component brain white matter and play pivotal role neuronal cell function, BDV's effects on not been clarified. Here, two strains, Hu-H1 (isolated from bipolar patient) Strain V (a laboratory strain), proliferation...