A5111365483- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Cancer Research and Treatments
- Virus-based gene therapy research
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- interferon and immune responses
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Retinoids in leukemia and cellular processes
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Cell death mechanisms and regulation
- PI3K/AKT/mTOR signaling in cancer
- Angiogenesis and VEGF in Cancer
- Acute Myeloid Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Vehicle emissions and performance
Jilin University
2007-2025
Anhui Agricultural University
2017-2024
The University of Melbourne
2024
Shanxi Medical University
2015-2024
Zhengzhou University
2017-2024
Chongqing Medical University
2010-2024
Dalian Medical University
2023-2024
Second Affiliated Hospital of Chongqing Medical University
2023-2024
Zhengzhou Central Hospital
2024
Capital Medical University
2024
Graphene oxide (GO) has attracted intensive interest in the biomedical field recent years. We investigate whether use of functional graphene as an efficient delivery system for delivering specific molecular antitumor therapeutics vivo could achieve a more excellent effect. Constitutive activation signal transducer and activator transcription 3 (Stat3) promotes survival wide spectrum human cancers. In this paper, we study behavior chemically functionalized with polyethylenimine polyethylene...
Esophageal squamous cell carcinoma (ESCC) is a poor-prognostic cancer type with extensive intra- and inter-patient heterogeneity in both genomic variations tumor microenvironment (TME). However, the patterns drivers of spatial microenvironmental ESCC remain largely unknown. Here, we generated multi-omic atlas by whole-exome, transcriptome, methylome sequencing 507 samples from 103 patients. We identified novel suppressor PREX2, accounting for 22% ESCCs frequent somatic mutations or...
Abstract The facultative anaerobic, invasive Salmonella enterica serovar typhimurium (S. typhimurium) has been shown to retard the growth of established tumors. We wondered if a more effective antitumor response could be achieved in vivo these bacteria were used as tools for delivering specific molecular therapeutics. Constitutively activated transcription factor signal transducer and activator 3 (STAT3) promotes survival number human In this study, we investigated relative efficacies...
Aberrations in the Hedgehog (Hh) signaling pathway are significantly prevailed various cancers, including B-cell lymphoma. A critical facet of Hh signal transduction involves dynamic regulation suppressor fused homolog (SUFU)-glioma-associated oncogene (GLI) complex within kinesin family member 7 (KIF7)-supported ciliary tip compartment. However, specific post-translational modifications SUFU-GLI this context have remained largely unexplored. Our study reveals a novel regulatory mechanism...
Increasing evidence highlights the important roles of tripartite motif containing 24 (TRIM24) in tumor initiation and malignant progression many tumors, including gastric cancer (GC). Although TRIM24 expression is remarkably upregulated during GC carcinogenesis, molecular mechanisms underlying dysregulation remain unexplored.In this study, miRNA target prediction tools were applied to explore miRNAs that potentially TRIM24. Western blot quantitative reverse-transcriptase PCR (qRT-PCR)...
Tbx18, Wt1, and Tcf21 have been identified as epicardial markers during the early embryonic stage. However, gene of mature cells remain unclear. Single-cell transcriptomic analysis was performed with Seurat, Monocle, CellphoneDB packages in R software standard procedures. Spatial transcriptomics on chilled Visium Tissue Optimization Slides (10x Genomics) Gene Expression Genomics). Space Ranger software. Immunofluorescence, whole-mount RNA situ hybridization X-gal staining were to validate...
Corrected by: Erratum for: Toosendanin Inhibits Hepatocellular Carcinoma Cells by Inducing Mitochondria-dependent ApoptosisPlanta Med 2010; 76(13): E4-E4DOI: 10.1055/s-0029-1241001
Abstract Oxaliplatin (L-OHP) is one of the effective chemotherapeutic drugs for colorectal cancer (CRC). Further investigation into molecular mechanism chemoresistance could improve outcomes patients with cancer. Recently, microRNAs have been reported as a key in drug resistance tumors. In this study, we aimed to investigate effects miR-153-5p L-OHP-resistant CRC cells, and its underlying mechanism. Downregulation was observed while upregulation enhances chemosensitivity CRC/L-OHP cells. The...
Purpose: Pneumonia is a respiratory disease with an increasing incidence in recent years. More and more studies have revealed that lncRNAs can regulate the transcriptional expression of target genes at different stage. Herein, we aimed to explore effect lncRNA MIAT LPS-induced pneumonia, further illuminate possible underlying mechanisms. Method results: Mice were intraperitoneally injected LPS, lung inflammation was evaluated. Microarray showed up-regulated pulmonary inflammation. And...
Esophageal squamous cell carcinoma (ESCC) is one of the most common types cancer in China. Artesunate (ART) used clinically as an anti-malarial agent and exhibits potent antiproliferative activity. In addition, ART has demonstrated remarkable antitumor activity, presenting a novel candidate for chemotherapy. However, its effect on ESCC remains unknown. The present study analyzed effects KYSE-150 line by assessing proliferation, death, migration/invasion biomechanical properties ART-treated...
Glioma is one of the most common tumors in China and chemotherapy critical for its treatment. Recent studies showed that benzyl isothiocyanate (BITC) could inhibit growth glioma cells, but mechanisms are not fully understood. This study explored inhibitory effect BITC on invasion angiogenesis U87MG human cells vitro vivo, as well potential mechanisms. It was found by inducing cell cycle arrest at phase G2/M. also demonstrated decreased expression cyclin B1, p21, MMP-2/9, VE-cadherin, CD44,...