A5101439394- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Hair Growth and Disorders
- RNA modifications and cancer
- Historical Gender and Feminism Studies
- RNA Research and Splicing
- Pulmonary Hypertension Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Skin and Cellular Biology Research
- Neurological Complications and Syndromes
- Plant-Microbe Interactions and Immunity
- High Altitude and Hypoxia
- Mycotoxins in Agriculture and Food
- Microfluidic and Capillary Electrophoresis Applications
- Lung Cancer Treatments and Mutations
- Neurological disorders and treatments
- Genomics, phytochemicals, and oxidative stress
- Microbial Inactivation Methods
- Autophagy in Disease and Therapy
- Plant Stress Responses and Tolerance
- Aortic aneurysm repair treatments
- Heart Failure Treatment and Management
- Liver Disease Diagnosis and Treatment
Shengli Oilfield Central Hospital
2025
Chinese Academy of Sciences
2024
University of Chinese Academy of Sciences
2024
Jiangxi Agricultural University
2024
Center for Excellence in Brain Science and Intelligence Technology
2024
Chongqing Emergency Medical Center
2024
Chongqing University
2024
Second Hospital of Hebei Medical University
2023
Chongqing Medical University
2023
Children's Hospital of Chongqing Medical University
2023
As a promising field of individualized therapy, non-coding RNA pharmacogenomics promotes the understanding different individual responses to certain drugs and acts as reasonable reference for clinical treatment. However, relevant information is scattered across published literature, which inconvenient researchers explore RNAs that are involved in drug resistance. To address this, we systemically identified validated predicted resistance-associated microRNAs long through manual curation...
Prostate cancer (PC) is one of the most common solid tumors in men. However, molecular mechanism PC remains unclear. Numerous studies have demonstrated that long noncoding RNA (lncRNA) can act as microRNA (miRNA) sponge, type competing endogenous RNAs (ceRNAs), which offers a novel viewpoint to elucidate mechanisms PC. Here, we proposed an integrative systems biology approach infer gain and loss ceRNAs First, re-annotated exon microarray data obtain lncRNA expression profiles Second, by...
To investigate the significance and relationship of glucose lipid metabolism, placental resistin, human carrier protein (LCN-2) expression in pregnant women with gestational diabetes mellitus (GDM) complicated by severe preeclampsia (SPE). A total 89 patients GDM SPE (G+S group) alone (GDM were included. Blood samples collected to measure metabolism indicators [fasting blood (FBG), fasting insulin (FINS), glycosylated hemoglobin (HbA1c), cholesterol (TC), triglycerides (TG), HDL-C, LDL-C],...
Abstract Inner Mongolia cashmere goats, as an important part of animal husbandry production, play role in fiber industry. In recent years, scientific research has made a lot explorations on the molecular regulation mechanism hair follicle cycle growth, but few studies have been reported development fetal period. This study was based completion 21 skin samples mRNA and miRNA sequencing 7 periods (45 days, 55 days,65 days,75 days,95 days,115 days 135 days) Cashmere goat. The target genes...
MicroRNAs (miRNAs) are a class of small noncoding RNA that, through mediating posttranscriptional gene regulation, play critical role in nearly all biological processes. Over the last decade it has become apparent that plant miRNAs may serve as novel functional component food with therapeutic effects including anti-influenza and antitumor. Rapeseed bee pollen good properties enhancing immune function well preventing treating disease. In this study, we identified exogenous from rapeseed mice...
Long non-coding RNAs (lncRNA) and microRNAs (miRNA) are new found classes of RNAs(ncRNAs) that not translated into proteins but regulate various cellular biological processes. In this study, we conducted a transcriptomic analysis ncRNA mRNA expression in Aohan fine wool sheep (AFWS) at different growth stages (embryonic day 90, embryonic 120, the birth), explored their relationship with follicle growth. total, 461 lncRNAs, 106 miRNAs, 1,009 mRNAs were to be differentially expressed during...
// Jing Wang 1, * , Fanlin Meng EnYu Dai 1 Feng Yang Shuyuan Xiaowen Chen Lei Yuwen 2 Wei Jiang College of Bioinformatics Science and Technology, Harbin Medical University, 150081, P. R. China The 2nd Affiliated Hospital, These authors have contributed equally to this work Correspondence to: Jiang, email: jiangwei@hrbmu.edu.cn Keywords: small molecule, miRNA, drug, functional similarity, microarray Received: November 26, 2015 Accepted: May 08, 2016 Published: 24, ABSTRACT MicroRNAs (miRNAs)...
The aim of this study was to evaluate the ability a 41-gene signature derived from breast cancer stem cells (BCSCs) estimate risk metastasis and survival in patients. centroid expression BCSCs applied as threshold classify patients into two separate groups—patients with high (high-EL) prognostic low (low-EL). predictive evaluated by Cox regression model compared against other popular tests, such Oncotype MammaPrint. Our results showed that significantly associated age (P = .0351) ER status...
Cisplatin (CDDP)-based chemotherapy is a standard first-line therapy for ovarian cancer. However, drug resistance remains major obstacle to its efficacy. Recently, increasing evidence suggested that the aberrant expression of microRNAs (miRNAs) may contribute resistance. Here, we proposed systems biology analysis strategy identify novel miRNAs potentially involved in CDDP human cancer cells. Firstly, identified candidate associated with using NCI-60 data. Next, differentially expressed genes...
Differentiating follicular thyroid adenoma (FTA) from carcinoma (FTC) remains challenging due to similar histological features separate invasion. In this study, we aim develop and validate DNA protein-based classifiers for FTA/FTC differentiation. We collected 2443 samples 1568 patients across 24 centers applied next-generation sequencing, as well discovery targeted proteomics. Machine learning models were developed compared utilizing and/or protein features. The model (AUC 0.899)...
Abstract miRNAs are key post-transcriptional regulators of many essential biological processes and their dysregulation has been validated in almost all human cancers. Restoring aberrantly expressed might be a novel therapeutics. Recently, studies have demonstrated that small molecular compounds can affect miRNA expression. Thus, prediction associations between molecules is important for investigation miRNA-targeted drugs. Here, we analyzed 39 miRNA-perturbed gene expression profiles then...
Recent studies have found that plant derived microRNA can cross-kingdom regulate the expression of genes in humans and other mammals, thereby resisting diseases. Can exogenous miRNAs cross blood-prostate barrier entry prostate then participate disease treatment?Using HiSeq sequencing RT-qPCR technology, we detected enriched prostates rats among normal group, BPH model group rape bee pollen group. To forecast functions these miRNAs, psRobot software TargetFinder were used to predict their...
Abstract Background Cashmere goats make an outstanding contribution to the livestock textile industry and their cashmere is famous for its slenderness softness has been extensively studied. However, there are few reports on molecular regulatory mechanisms of secondary hair follicle growth cycle in goats. In order explore regular transition through role key genes this cycle, we used a transcriptome sequencing technique sequence skin Inner Mongolian during different months. We analyzed...
The objectives of this study were to assess the changes in left myocardial function after chemotherapy for childhood lymphoma and observe predictive or monitor value cancer treatment-related cardiac dysfunction (CTRCD) by speckle-tracking echocardiography.A total 23 children with histopathological diagnoses included, age-matched normal controls. Comparative analysis clinical serological tests heart strain parameters lymphoma, including ventricular global longitudinal (LVGLS); work (GMW)...
It is widely accepted that the periodic cycle of hair follicles controlled by biological clock, but molecular regulatory mechanisms follicle have not been thoroughly studied. The secondary cashmere goat characterized seasonal changes throughout life. In cycle, initiation great significance for regeneration. To provide a reference research, our study compared differences in mRNA expression and microRNA during growth repose stages skin samples. Through association analysis, we found microRNAs...
Numerous studies have shown that plant long noncoding RNAs (lncRNAs) play an important regulatory role in the response to environmental stress. However, there are no reports on lncRNAs regulating and enhancing aluminum (Al) stress tolerance legumes. This study analyzed of Al legume model Medicago truncatula . A total 219.49 Gb clean data were generated: 3,284 lncRNA genes identified, which 515 differentially expressed, 1,254 new functionally annotated through database alignment. We further...
Abstract The functional role of glutamatergic (vGluT2) neurons in the pedunculopontine nucleus (PPN) modulating motor activity remains controversial. Here, we demonstrated that vGluT2 rostral PPN is correlated with locomotion and ipsilateral head-turning. Beyond these functions, found PPN-vGluT2 remarkably respond to salient stimuli. Furthermore, systematically traced upstream downstream projections identified two from caudal pontine reticular nucleus/anterior gigantocellular (PnC/GiA) zona...
Abstract Background: Cashmere goats make an outstanding contribution to the livestock textile industry and their cashmere is famous for its slenderness softness has been extensively studied. However, there are few reports on molecular regulatory mechanisms of secondary hair follicle growth cycle in goats. In order explore regular transition through role key genes this cycle, we used a transcriptome sequencing technique sequence skin Inner Mongolian during different months. We analyzed...
Due to the considerable heterogeneity of head and neck squamous cell carcinoma (HNSCC), individuals with comparable TNM stages who receive same treatment strategy have varying prognostic outcomes. In HNSCC, immunotherapy is developing quickly has shown effective. We want develop an immune-related gene (IRG) model forecast prognosis response patients. order analyze differential expression in normal malignant tissues, we first identified IRGs that were differently expressed. Weighted...